Defining and Measuring Primary Medication Nonadherence: Development of a Quality Measure

Adams, Alex J.; Stolpe, Samuel F.

doi:10.18553/jmcp.2016.22.5.516

Cited by 40 publications

(45 citation statements)

References 36 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To address this, we have presented an extensive list of factors associated with PMN in each of the six chronic diseases that could be useful in identifying patients at risk for PMN to receive timely interventions to keep them adherent to treatment. In addition, we identified factors that contributed to heterogeneity between studies; this highlights the need for future studies to adopt the recommendations by agencies such as ISPOR and the Pharmacy Quality Alliance (PQA) to facilitate comparability across studies.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of and factors associated with primary medication non‐adherence in chronic disease: A systematic review and meta‐analysis

et al. 2019

View full text Add to dashboard Cite

Background: Primary medication non-adherence (PMN), defined as failure to obtain newly prescribed medications, results in adverse clinical and economic outcomes.We aimed to (a) assess the prevalence of PMN in six common chronic diseases: asthma and/ or chronic obstructive pulmonary disease, depression, diabetes mellitus, hyperlipidaemia, hypertension and osteoporosis; (b) identify and categorise factors associated with PMN; (c) explore characteristics that contributed to heterogeneity between studies. Methods:We performed a systematic search in MEDLINE, Embase, Cochrane Library, CINAHL and PsycINFO. Studies published in English between January 2008 and August 2018 assessing PMN in subjects aged ≥18 years were included. We used the Cochrane risk of bias tool, Newcastle-Ottawa Scale and National Heart, Lung and Blood Institute Quality Assessment Tool to assess the quality of randomised controlled trials, cohort and cross-sectional studies, respectively. Findings were reported using the PRISMA checklist. PMN rates were pooled using a random effects model. We summarised factors associated with PMN descriptively. Subgroup analysis was performed to explore sources of heterogeneity. Results:We screened 3083 articles and included 33 (5 randomised controlled trials, 26 cohort and 2 cross-sectional studies, n = 539 156), of which 31 (n = 519 971) were used in meta-analysis. The pooled PMN rate was 17% (95% CI: 15%-20%). Pooled PMN rates were highest in osteoporosis (25%, 95% CI: 7%-44%) and hyperlipidaemia (25%, 95% CI: 18%-32%) and lowest in diabetes mellitus (10%, 95% CI: 7%-12%).Factors commonly associated with PMN include younger age, number of concurrent medications, practitioner specialty and higher co-payment. Type of chronic disease, age, study setting and PMN definition contributed to heterogeneity between studies (all P < 0.001). Conclusion:Primary medication non-adherence is common among patients with chronic diseases and more needs to be done to address this issue in order to improve patient outcomes. Future PMN studies could benefit from greater standardisation to enhance comparability.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence of and factors associated with primary medication non‐adherence in chronic disease: A systematic review and meta‐analysis

et al. 2019

View full text Add to dashboard Cite

show abstract

“…It is an active role, collaboration with the physician with no place for blame; self-motivated decision to adhere the advice and understood self-regulation [6, 7]. Medication non-adherence is dose not taken, irregular dosing and discontinuation medication [8, 9].…”

Section: Introductionmentioning

confidence: 99%

Medication non-adherence and associated factors among diabetes patients in Felege Hiwot Referral Hospital, Bahir Dar city administration, Northwest Ethiopia

Abate

2019

BMC Res Notes

View full text Add to dashboard Cite

Objective This study was aimed to assess medication non-adherence and associated factors among adult diabetes in Felege Hiwot Referral Hospital Bahir Dar city administration. To overcome this object, a cross-sectional study was conducted among 416 randomly selected diabetes patients at the Felege Hiwot Referral Hospital (FHRH). Eight item Morisky Medication Adherence Scale questionnaire was used to assess medication non-adherence. Binary logistic regression was applied to analyze the collected data. P-value less than 0.05 with 95% confidence interval was considered statistically significant between dependent and explanatory variables. Result Among 416 participants, 242 (58.2%) were male diabetes patient. The mean age (± SD) of the study participant was 45.4 (± 16. 7) years. Based on the MMAS-8 scale, non-adherence to diabetes medication was 68.8% [95% CI 62.0, 71.4]. The multivariate analysis, age group from 18 to 35 years old (AOR: 2.26: 95% CI 1.23, 5.58), single (AOR: 3.55; 95% CI 1.59, 7.29), fear of diabetes related complication (AOR: 3.01; 95% CI 1.66, 5.53) and feeling worse (AOR: 2.55; 95% CI 1.45, 4.53) were significantly associated with non-adherence to prescribed diabetes medications. Therefore, developing a more intensive communication strategy and improving the quality of prescribed drug compliance could improve the level of adherence.

show abstract

“…To date, studies have used data from pharmacy benefit management companies and claims data sets to define PMN rates across subpopulations and/or medication classes. 1, 2, 6, 18, 19, 23–26 Researchers in pediatric studies have calculated PMN rates between 7% and 25%. 27–30 To our knowledge, however, an assessment of pediatric PMN rates across an entire region, regardless of clinical setting, medication class, or payer, has not been pursued.…”

mentioning

confidence: 99%

Poverty, Transportation Access, and Medication Nonadherence

Hensley¹,

Heaton²,

Kahn³

et al. 2018

Pediatrics

View full text Add to dashboard Cite

show abstract

Defining and Measuring Primary Medication Nonadherence: Development of a Quality Measure

Cited by 40 publications

References 36 publications

Prevalence of and factors associated with primary medication non‐adherence in chronic disease: A systematic review and meta‐analysis

Prevalence of and factors associated with primary medication non‐adherence in chronic disease: A systematic review and meta‐analysis

Medication non-adherence and associated factors among diabetes patients in Felege Hiwot Referral Hospital, Bahir Dar city administration, Northwest Ethiopia

Poverty, Transportation Access, and Medication Nonadherence

Contact Info

Product

Resources

About