Deficits of memory, executive functioning and attention following infarction in the thalamus; a study of 22 cases with localised lesions

Werf, Ysbrand D. van der; Scheltens, Philip; Lindeboom, J.; Witter, Menno P.; Uylings, H.B.M.; Jolles, Jelle

doi:10.1016/s0028-3932(03)00059-9

Cited by 345 publications

(254 citation statements)

References 53 publications

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“…In particular, the model simulates how specific and nonspecific thalamic nuclei regulate learning via temporal cycles of match/resonance and mismatch/reset, wherein learning is facilitated during match/resonance states and reduced during mismatch/reset states. The predicted involvement of the nonspecific thalamus in learning is consistent with lesion studies showing a role for the nonspecific intralaminar/midline thalamic nuclei in declarative memory (van Der Werf et al, 2003). Moreover, Kraus et al (1994) have shown that the nonspecific thalamic nuclei, but not the specific thalamic nuclei, show significant differential activation in states of match vs. mismatch, consistently with the model prediction that the nonspecific pathway is sensitive to the degree of mismatch between bottom-up and top-down cortical signals.…”

Section: Discussionsupporting

confidence: 83%

Spikes, synchrony, and attentive learning by laminar thalamocortical circuits

2008

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Section: Discussionsupporting

confidence: 83%

Spikes, synchrony, and attentive learning by laminar thalamocortical circuits

2008

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“…An obvious problem is that, in all relevant cases, there is additional diencephalic damage. Even so, the potential association between these nuclei and recognition is underpinned by convergent evidence that anterior thalamic nuclei dysfunction contributes to anterograde amnesia (Aggleton and Sahgal 1993;Aggleton and Brown 1999;Harding et al 2000;Van der Werf et al 2000, 2003b, supported by the presence of reciprocal connections between the hippocampal formation and the anterior thalamic nuclei ( Fig. 1; Amaral and Cowan 1980;DeVito 1980;Aggleton et al 1986).…”

Section: The Anterior Thalamic Nucleimentioning

confidence: 96%

“…Comparisons of when thalamic strokes do and do not induce amnesia have consistently found that damage to this tract is the best predictor of memory loss (Von Cramon et al 1985;Ghika-Schmid and Bogousslavsky 2000;Van der Werf et al 2000, 2003bCarrera et al 2004). One of these studies also linked recognition deficits to mammillothalamic tract damage ( Van der Werf et al 2003b). Unfortunately, the recognition tests were based on material previously acquired and tested in recall tests, making the specificity of any recognition impairments far more difficult to determine (Tsivilis et al 2008).…”

Section: The Anterior Thalamic Nucleimentioning

confidence: 99%

“…A recent review (Carlesimo et al 2011), which combined the findings from 41 previous studies of patients with thalamic strokes (including Van der Werf et al 2003b), considered a total of 83 patients with vascular infarcts confirmed by MRI or CT. Of the 55 patients with presumed mammillothalamic tract damage, 95% had evidence of anterograde amnesia, but only 46% of the 28 patients without mammillothalamic tract damage had amnesia (Carlesimo et al 2011). One of the former patients was a 38-yr-old man (GP) who suffered a stroke that resulted in bilateral damage to the mammillothalamic tract and the ventral anterior nucleus, along with unilateral damage to the right inferior thalamic peduncle (Carlesimo et al 2007).…”

Section: The Anterior Thalamic Nucleimentioning

confidence: 99%

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Unraveling the contributions of the diencephalon to recognition memory: A review

Aggleton¹,

Dumont²,

Warburton³

2011

Learn. Mem.

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Both clinical investigations and studies with animals reveal nuclei within the diencephalon that are vital for recognition memory (the judgment of prior occurrence). This review seeks to identify these nuclei and to consider why they might be important for recognition memory. Despite the lack of clinical cases with circumscribed pathology within the diencephalon and apparent species differences, convergent evidence from a variety of sources implicates a subgroup of medial diencephalic nuclei. It is supposed that the key functional interactions of this subgroup of diencephalic nuclei are with the medial temporal lobe, the prefrontal cortex, and with cingulate regions. In addition, some of the clinical evidence most readily supports dual-process models of recognition, which assume two independent cognitive processes (recollective-based and familiarity-based) that combine to direct recognition judgments. From this array of information a "multi-effect multinuclei" model is proposed, in which the mammillary bodies and the anterior thalamic nuclei are of preeminent importance for recollective-based recognition. The medial dorsal thalamic nucleus is thought to contribute to familiarity-based recognition, but this nucleus, along with various midline and intralaminar thalamic nuclei, is also assumed to have broader, indirect effects upon both recollective-based and familiarity-based recognition.Clinical studies repeatedly show that diencephalic pathology can impair recognition memory. Even so, there is no agreed locus within the diencephalon responsible for this memory loss and, hence, no agreed mechanism to explain the impairment. The present review examines both clinical and animal findings, and from this information a multi-effect multi-nuclei (MEMN) model emerges to explain the contributions of the diencephalon to recognition memory.At the outset, it is necessary to refine the focus of this review and to define some of its principal terms. The diencephalon comprises the thalamus and hypothalamus but, as will be explained, only the more medial parts of the diencephalon will be considered in detail. Recognition memory refers to the ability to detect whether a stimulus (e.g., a word, face, picture, object, or sound) has previously been encountered. As a consequence, this review is not about item identification (sometimes also confusingly referred to as recognition). Likewise, conditions that have broad disruptive effects on cognition, e.g., dementia, will not be considered even though recognition is typically impaired. Distinctions will be made between "item recognition," where the task is to determine if an individual item is novel or familiar, and "associative recognition," where all the individual items being experienced are familiar, but their particular combination is novel. A further, distinct ability is "recency" discrimination-the ability to determine which of two familiar stimuli has been experienced more recently. Both studies of amnesia and electrophysiological recordings show how recency memory and recogniti...

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“…This accuracy is even more essential in case of 2 minimally or non-invasive surgical interventions when there is no electrophysiological control for the target position, such as in Gamma Knife radiosurgery (Friehs et al, 2007). In addition to surgical treatment, neuroscience research also relies on robust identification of individual thalamic structures for functional neuroimaging studies (e.g Devlin et al (2006)) or for localizations of traumatic lesions such as thalamic infarcts (Van der Werf et al, 2003;Montes et al, 2005).…”

Section: Introductionmentioning

confidence: 99%