Déficit de glucosa-6-fosfato-deshidrogenasa (G6PD) en países occidentales. Revisión bibliográfica

High-Dose Vitamin C: How an Orange Can Be a Lemon

“…Patel et al (1) concluded that apart from one trial which reported increased rates of hypernatremia, no other demonstrated increased adverse event rates when using IV vitamin C doses greater than 10 g per day. Glucose-6 phosphate dehydrogenase deficiency (G6PD) (2) is the most common human enzyme defect, and the vast majority of G6PD patients are, unless exposed to certain triggers, asymptomatic (2). Increased migration has clearly increased the number of asymptomatic G6PD patients in Western countries (2).…”

“…Glucose-6 phosphate dehydrogenase deficiency (G6PD) (2) is the most common human enzyme defect, and the vast majority of G6PD patients are, unless exposed to certain triggers, asymptomatic (2). Increased migration has clearly increased the number of asymptomatic G6PD patients in Western countries (2). Administration of high-dose vitamin C, far above 6 g per day (as in the meta-analysis described by Patel et al [1]), will risk possible life-threatening methemoglobinemia in previously asymptomatic patients not screened for G6PD (2, 3).…”

“…Increased migration has clearly increased the number of asymptomatic G6PD patients in Western countries (2). Administration of high-dose vitamin C, far above 6 g per day (as in the meta-analysis described by Patel et al [1]), will risk possible life-threatening methemoglobinemia in previously asymptomatic patients not screened for G6PD (2, 3).…”