High-Dose Vitamin C: How an Orange Can Be a Lemon

Honoré, Patrick M.; Redant, Sébastien; Djimafo, Pharan; Préseau, Thierry; Cismas, Bogdan Vasile; Kaefer, Keitiane; Gutierrez, Leonel Barreto; Anane, Sami; Gallerani, Andrea; Attou, Rachid

doi:10.1097/ccm.0000000000005571

Critical Care Medicine

2022

DOI: 10.1097/ccm.0000000000005571

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High-Dose Vitamin C: How an Orange Can Be a Lemon

Patrick M. Honoré

Sébastien Redant

Pharan Djimafo

et al.

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“…We thank Honore et al (1) for their interest and careful attention to our Systematic Review and Meta-Analysis (SR-MA) on IV vitamin C (IVVC) in critically ill patients (2). By citing a scoping review (3), they point out that high-dose IVVC is associated with numerous adverse effects and call for clinicians to remain on-guard when initiating high-dose IVVC.…”

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Critical Care Medicine www.ccmjournal.org e721 populations of critically ill patients, several RCTs are underway. Fortunately, most have safeguards in place, including the exclusion of patients with known G6PD deficiency and oxalate nephropathy ("primum non nocere") and for patients with unknown G6PD status, monitoring for serious adverse events and using enhanced point-of-care techniques ("secundum cavere").

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Risk of Hypovitaminosis and Vitamin C Deficiency in Pediatric Patients Undergoing Cardiopulmonary Bypass

Al‐Subu¹,

Long²,

Nelson³

et al. 2023

Pediatr Cardiol

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High-Dose Vitamin C: How an Orange Can Be a Lemon

Cited by 2 publications

References 5 publications

The authors reply

The authors reply

Risk of Hypovitaminosis and Vitamin C Deficiency in Pediatric Patients Undergoing Cardiopulmonary Bypass

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