Deficient Neurogenesis in Forebrain-Specific Presenilin-1 Knockout Mice Is Associated with Reduced Clearance of Hippocampal Memory Traces

Feng, Ru; Rampon, Claire; Tang, Ya Ping; Shrom, David; Jin, Janice; Kyin, Maureen; Sopher, Bryce L.; Martin, George M.; Kim, Seong Hun; Langdon, Ronald B.; Sisodia, Sangram S.; Tsien, Joe Z.

doi:10.1016/s0896-6273(01)00523-2

Cited by 432 publications

(280 citation statements)

References 62 publications

(8 reference statements)

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“…Our data on exercise and memory retention seem to contradict those of Feng et al (2001), who stated that hippocampal neurogenesis might serve to remove outdated information from the hippocampus. Feng and coworkers reported that an increase in neurogenesis after acquisition of a learning task impairs memory retention, whereas we see an improvement.…”

Section: Exercise Promotes Hippocampal Neurogenesiscontrasting

confidence: 99%

Exercise improves memory acquisition and retrieval in the Y-maze task: Relationship with hippocampal neurogenesis.

Borght¹,

Havekes²,

Bos³

et al. 2007

Behavioral Neuroscience

199

151

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Exercise improves memory acquisition and retrieval in the Y-maze task: Relationship with hippocampal neurogenesis van der Borght, K.; Havekes, Robbert; Bos, T.; Eggen, Bartholomeus; van der Zee, Eelke University of Groningen Enhanced physical activity is associated with improvements in cognitive function in rodents as well as in humans. The authors examined in detail which aspects of learning and memory are influenced by exercise, using a spatial Y-maze test combined with a 14-day exercise paradigm at different stages of learning. The authors show that 14 days of wheel running promotes memory acquisition, memory retention, and reversal learning. The exercise paradigm that was employed also significantly increased the number of maturing neurons, suggesting that an increase in neurogenesis underlies the positive effects of exercise on Y-maze performance. Finally, the authors show that memory acquisition in itself does not have a major impact on the number of immature neurons. However, memory retention testing and reversal learning both cause a significant reduction in the number of doublecortin and Ser133-phosphorylated pCREB-positive cells, indicating that a decrease in neurogenesis might be a prerequisite for optimal memory retrieval.

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Section: Exercise Promotes Hippocampal Neurogenesiscontrasting

confidence: 99%

Exercise improves memory acquisition and retrieval in the Y-maze task: Relationship with hippocampal neurogenesis.

Borght¹,

Havekes²,

Bos³

et al. 2007

Behavioral Neuroscience

199

151

View full text Add to dashboard Cite

show abstract

“…This will not be an easy task, since the region of origin of the new CA1 neurons is not unequivocally shown. A nonselective inhibition of neurogenesis by mitotic inhibitors or irradiation will not be sufficient to solve the issue, since such treatment is known to impair learning and memory also in nonischemic animals, possibly through inhibition of neurogenesis in the subgranular zone (Feng et al, 2001;Raber et al, 2004;Shors et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Reappearance of Hippocampal CA1 Neurons after Ischemia is Associated with Recovery of Learning and Memory

Bendel

Bueters

Euler

et al. 2005

J Cereb Blood Flow Metab

157

116

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The pyramidal neurons of the hippocampal CA1 region are essential for cognitive functions such as spatial learning and memory, and are selectively destroyed after cerebral ischemia. To analyze whether degenerated CA1 neurons are replaced by new neurons and whether such regeneration is associated with amelioration in learning and memory deficits, we have used a rat global ischemia model that provides an almost complete disappearance (to approximately 3% of control) of CA1 neurons associated with a robust impairment in spatial learning and memory at two weeks after ischemia. We found that transient cerebral ischemia can evoke a massive formation of new neurons in the CA1 region, reaching approximately 40% of the original number of neurons at 90 days after ischemia (DAI). Co-localization of the mature neuronal marker neuronal nuclei with 5-bromo-2 0 -deoxyuridine in CA1 confirmed that neurogenesis indeed had occurred after the ischemic insult. Furthermore, we found increased numbers of cells expressing the immature neuron marker polysialic acid neuronal cell adhesion molecule in the adjacent lateral periventricular region, suggesting that the newly formed neurons derive from this region. The reappearance of CA1 neurons was associated with a recovery of ischemia-induced impairments in spatial learning and memory at 90 DAI, suggesting that the newly formed CA1 neurons restore hippocampal CA1 function. In conclusion, these results show that the brain has an endogenous capacity to form new nerve cells after injury, which correlates with a restoration of cognitive functions of the brain.

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“…However, 1 h/d of EE was sufficient to attenuate deficits in spatial learning in the MWM following FP (Fig. 6), and 3 h/d of EE produced increases in neurogenesis and improvements in memory and learning in intact mice [18] and rats [7]. Even shorter durations, as little as 40 min/d, was sufficient to produce alterations in mRNA and brain weight in developing animals [13].…”

Section: Discussionmentioning

confidence: 94%

“…First, specific pathogen free (SPF) guidelines and space restrictions of our animal vivarium prevented us from housing animals in EE on a continuous basis. Second, whereas most previous studies have used continuous housing in an enriched environment, there have been a few reports demonstrating that short daily periods of EE, ranging from 45 min to 3 hours per day [13,18], could produce alterations in the brain. Third, shorter periods of EE may be more translatable to certain clinical situations than continuous EE.…”

Section: Environmental Enrichmentmentioning

confidence: 99%

Environmental enrichment increases progenitor cell survival in the dentate gyrus following lateral fluid percussion injury

Gaulke

Horner

Fink

et al. 2005

Molecular Brain Research

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Neurons in the hilus of the dentate gyrus are lost following a lateral fluid percussion injury. Environmental enrichment is known to increase neurogenesis in the dentate in intact rats, suggesting that it might also do so following fluid percussion injury, and potentially provide replacements for lost neurons. We report that 1 hour of daily environmental enrichment for 3 weeks increased the number of progenitor cells in the dentate following fluid percussion injury, but only on the ipsilesional side. In the dentate granule cell layer, but not the hilus, most progenitors had a neuronal phenotype. The rate of on going cell proliferation was similar across groups. Collectively these results suggest that the beneficial effects of environmental enrichment on behavioral recovery following FP injury are not attributable to neuronal replacement in the hilus, but may be related to increased neurogenesis in the granule cell layer.

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Deficient Neurogenesis in Forebrain-Specific Presenilin-1 Knockout Mice Is Associated with Reduced Clearance of Hippocampal Memory Traces

Cited by 432 publications

References 62 publications

Exercise improves memory acquisition and retrieval in the Y-maze task: Relationship with hippocampal neurogenesis.

Exercise improves memory acquisition and retrieval in the Y-maze task: Relationship with hippocampal neurogenesis.

Reappearance of Hippocampal CA1 Neurons after Ischemia is Associated with Recovery of Learning and Memory

Environmental enrichment increases progenitor cell survival in the dentate gyrus following lateral fluid percussion injury

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