Exercise improves memory acquisition and retrieval in the Y-maze task: Relationship with hippocampal neurogenesis.

Borght, Karin van der; Havekes, Robbert; Bos, Thomas; Eggen, Bart J. L.; Zee, Eddy A. van der

doi:10.1037/0735-7044.121.2.324

Cited by 200 publications

(168 citation statements)

References 64 publications

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“…This is consistent with the findings of previous studies showing that BDNF is increased after spatial learning and memory tasks (Mizuno et al, 2003). Radak et al reported that reduced oxidative damage in rat brain with voluntary exercise is associated with increased BDNF levels (Radak et al, 2001) and neurogenesis (Van der Borght et al, 2007). In addition, mutant BDNF and BDNF receptor blocker were associated with impaired spatial learning and memory formation in Morris maze and eight-arm radial maze, and LTP (Linnarsson et al, 1997;Minichiello et al, 1999).…”

Section: Discussionsupporting

confidence: 84%

Changes in spatial memory and BDNF expression to concurrent dietary restriction and voluntary exercise

Khabour¹,

Alzoubi²,

Alomari³

et al. 2009

Hippocampus

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Substantial data suggest that cognitive function can be influenced by many lifestyle activities associated with changes in energy metabolism such as exercise and diet. In the current study, we investigated the combined effects of voluntary exercise (access to running wheels) and dietary restriction (every other day fasting, EODF) on spatial memory formation and on the levels of brain-derived neurotrophic factor (BDNF) in the hippocampus of Wistar male rats. Spatial learning and memory formation was assessed using the radial arm water maze (RAWM) paradigm, while BDNF protein was measured using ELISA test. Voluntary exercise and/or EODF were instituted for 6 weeks. Voluntary exercise alone significantly enhanced short-term, intermediate-term, and long-term memory formation, and increased BDNF protein levels in the hippocampus. EODF enhanced mean running wheel activity by approximately twofold. However, EODF did not modulate the effects of exercise on memory formation and expression of BDNF. In addition, EODF alone had no effect on memory and BDNF protein in the hippocampus. In conclusion, results of this study indicate that exercise enhanced while EODF had neutral effect on both spatial memory formation and hippocampus BDNF levels.

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Section: Discussionsupporting

confidence: 84%

Changes in spatial memory and BDNF expression to concurrent dietary restriction and voluntary exercise

Khabour¹,

Alzoubi²,

Alomari³

et al. 2009

Hippocampus

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show abstract

“…Taken together, this data indicates that physical exercise has a significant impact on the development of immature and mature neurons. Our findings of increased neurogenesis with physical exercise are in line with previous reports using adult and aged wild-type mice that found physical exercise augments the rate of hippocampal neuronal differentiation, maturation and survival [48][49][50][51][52]. Similarly, in the APP23 transgenic mice, physical exercise was able to increase the number of newborn granule cells in the dentate gyrus [21].…”

Section: Discussionsupporting

confidence: 82%

A Comparative Study Evaluating the Impact of Physical Exercise on Disease Progression in a Mouse Model of Alzheimer’s Disease

Maliszewska-Cyna

Xhima

Aubert

2016

JAD

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Abstract. Evidence suggests that physical exercise can serve as a preventive strategy against Alzheimer's disease (AD). In contrast, much less is known about the impact of exercise when it is introduced after cognitive deficits are established. Using the TgCRND8 mouse model of amyloidosis, we compared the effects of exercise as an intervention strategy aimed at altering disease progression. Voluntary running for 1 month or 2 months was introduced in 3-month-old TgCRND8 mice, which exhibit amyloid-beta (A␤) plaque pathology and cognitive deficits at this age. Specifically, we examined A␤ plaque load, spatial memory, and neurogenesis in the dentate gyrus in the hippocampus. After 1 month of running, TgCRND8 mice spent more time in the novel arm of the Y-maze compared to the familiar arms, indicating improved memory. The levels of doublecortin (a marker of immature neurons) were increased in TgCRND8 mice running for 1 month, but with no significant difference in the number of new mature neurons or plaque burden. As the disease progressed, running prevented further deficits in the Y-maze performance and hippocampal neurogenesis and it reduced plaque load pathology in TgCRND8 mice running for 2 months, compared to non-running transgenics. Therefore, the impact of running on memory, neurogenesis, and amyloid pathology was of greater significance when sustained through later stages of the disease.

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“…Beneficial effects of these therapies include improved learning and memory, 27,28 improved motor function, 13,16 and enhancement of proteins involved in brain plasticity such as BDNF, cAMP response-elementbinding protein, and synapsin-1. 11,27,29 -31 Consistent with these findings, we found that a challenging and graduated rehabilitation therapy consisting of running exercise and reach training significantly improved skilled reaching in the staircase task after focal ischemia in rats.…”

Section: Discussionmentioning

confidence: 99%

Brain-Derived Neurotrophic Factor Contributes to Recovery of Skilled Reaching After Focal Ischemia in Rats

Ploughman

Windle

MacLellan

et al. 2009

Stroke

323

222

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Background and Purpose-Brain-derived neurotrophic factor (BDNF) is involved in neuronal survival, synaptic plasticity, learning and memory, and neuroplasticity. Further, exogenous treatment with BDNF or exposing animals to enrichment and exercise regimens, which also increase BDNF, enhances behavioral recovery after brain injury. Thus, the beneficial effects of rehabilitation in promoting recovery after stroke may also depend on BDNF. We tested this hypothesis by evaluating the contribution of BDNF to motor skill relearning after endothelin-1-induced middle cerebral artery occlusion in rats. Methods-Antisense BDNF oligonucleotide, which blocks the expression of BDNF (or saline vehicle) was infused into the contralateral lateral ventricle for 28 days after ischemia. Animals received either a graduated rehabilitation program, including running exercise and skilled reaching training, which simulates clinical practice, or no rehabilitation. Functional recovery was assessed with a battery of tests that measured skilled reaching, forelimb use asymmetry, and foraging ability. Results-Rehabilitation significantly improved skilled reaching ability in the staircase task. Antisense BDNF oligonucleotide effectively blocked BDNF mRNA, and negated the beneficial effects of rehabilitation on recovery of skilled reaching. Importantly, antisense BDNF oligonucleotide did not affect reaching with the unaffected limb, body weight, infarct size, or foraging ability, indicating the treatment was specific to relearning of motor skill after ischemia. Conclusions-This study is the first to identify a critical role for BDNF in rehabilitation-induced recovery after stroke, and our results suggest that new treatments to enhance BDNF would constitute a promising therapy for promoting recovery of function after stroke.

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Exercise improves memory acquisition and retrieval in the Y-maze task: Relationship with hippocampal neurogenesis.

Cited by 200 publications

References 64 publications

Changes in spatial memory and BDNF expression to concurrent dietary restriction and voluntary exercise

Changes in spatial memory and BDNF expression to concurrent dietary restriction and voluntary exercise

A Comparative Study Evaluating the Impact of Physical Exercise on Disease Progression in a Mouse Model of Alzheimer’s Disease

Brain-Derived Neurotrophic Factor Contributes to Recovery of Skilled Reaching After Focal Ischemia in Rats

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