Deficiency of Vitamin C and Vitamin P in Man*1

Chemistry and pharmacology of the citrus bioflavonoid hesperidin

“…Since then, hesperidin has increasingly been used as a therapeutic agent for increasing capillary resistance. Scarborough (1940) used hesperidin in the treatment of purpurea, resulting from the use of arsenicals and in the treatment of syphilis. He reported that hesperidin, as well as hesperetin, were active for increasing capillary resistance Higby (1941) reported the successful use of hesperidin in the clinical treatment of haemorrhagic purpurea and disorders arising from abnormal capillary fragility.…”

Cause and Significance of Seasonal Variation in the Haemorrhagic Tendency in the Newborn

“…This lack of parallelism between pathologic permeabiity and fragility of the capillaries suggests that the underlying cause for the pathologic changes in increased permeability and increased Eragility is different. In the origin of increased fragility lack of vitamin P (Armentano et al, 1936;Rusznyaik and Szent-y6rgyi, 1936;Zacho, 1939;Scarborough, 1940;Rapaport, 1941;Bicknel and Prescott, 1946) has been described as of outstanding importance. Less is known about increased permeability.…”

Early Vitamin-deficiency States

“…Petechial haemorrhages are usually moderately advanced signs, and although increased capillary fragility is more and more attributed to vitamin-P deficiency (Scarborough, 1940), the two substances appear to be associated in nature.…”