2022
DOI: 10.36660/abc.20201257
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Deficiência de Ferro na Insuficiência Cardíaca com Fração de Ejeção Reduzida: Fisiopatologia, Diagnóstico e Tratamento

Abstract: Resumo A deficiência de ferro (DF) ou ferropenia é uma importante comorbidade na insuficiência cardíaca com fração de ejeção reduzida (ICFER) estável, e muito prevalente tanto nos anêmicos como não anêmicos. A ferropenia na ICFER deve ser pesquisada por meio da coleta de saturação de transferrina e ferritina. Há dois tipos de ferropenia na IC: absoluta, em que as reservas de ferro estão depletadas; e funcional, onde o suprimento de ferro é inadequado apesar das reservas normais. A ferropenia está as… Show more

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Cited by 2 publications
(1 citation statement)
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“…World Journal of Cardiovascular Diseases Patients with HF may present pre-existing absolute anemia due to blood loss, unbalanced diet, use of anticoagulants or malnutrition [54]. Iron deficiency could affect myocardiocyte metabolism through the imbalance of the production of ATP, leading by itself to cell energetic and mitochondrial imbalance with impairment of ventricular performance and HF with reduced ejection fraction (HFrEF) [56] [62]. Indeed, according to the "iron hypothesis", iron deficiency can itself trigger HF leading to myocardial and mitochondria energetic failure in HFrEF [56] [61] [62] (Figure 1).…”
Section: Manlov Et Al Observed a Key Role Of Iron In Pathophysiology ...mentioning
confidence: 99%
“…World Journal of Cardiovascular Diseases Patients with HF may present pre-existing absolute anemia due to blood loss, unbalanced diet, use of anticoagulants or malnutrition [54]. Iron deficiency could affect myocardiocyte metabolism through the imbalance of the production of ATP, leading by itself to cell energetic and mitochondrial imbalance with impairment of ventricular performance and HF with reduced ejection fraction (HFrEF) [56] [62]. Indeed, according to the "iron hypothesis", iron deficiency can itself trigger HF leading to myocardial and mitochondria energetic failure in HFrEF [56] [61] [62] (Figure 1).…”
Section: Manlov Et Al Observed a Key Role Of Iron In Pathophysiology ...mentioning
confidence: 99%