Iron and Heart Failure: Current Concepts and Emerging Pharmacological Paradigms
Maria Rosaria De Pascale,
Maria Beatrice Rondinelli,
Flora Ascione
et al.
Abstract:Background: Emerging evidence has recognized that anemia and iron deficiency are recurrent comorbidities in chronic heart failure (HF) and several trials have established that iron administration improves myocardial asset and clinical scenario in HF. Purpose: Recent acquisitions suggest that iron deficiency represents a concrete bias in the pathogenetic mechanism of chronic HF, so we have investigated the putative role of the hepcidin/ferroportin axis in the cardiovascular setting to advocate novel pharmacolog… Show more
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