Defibrillator and non-ischaemic dilated cardiomyopathy: a never ending story

Notaristefano, Francesco; Ambrosio, Giuseppe

doi:10.1093/eurheartj/suz005

Cited by 6 publications

(6 citation statements)

References 7 publications

(8 reference statements)

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“…Учитывая тот факт, что число пациентов с систолической дисфункцией ЛЖ измеряется миллионами, на первый план выходят экономические вопросы целесообразности имплантации большого числа КД. В связи с этим многие эксперты призывают искать дополнительные факторы риска для определения показаний к имплантации КД в огромной когорте пациентов с ФВ ЛЖ <35%, особенно, в случае неишемического генеза СН [7]. Обсуждаются значимость верификации генетической природы болезни [8], наличие семейного анамнеза ВСС [9], обмороков неясного генеза [10], неустойчивой желудочковой тахикардии (ЖТ) [11], отсроченного накопления контрастного препарата в миокарде по данным магнитно-резонансной томографии (МРТ) [12] и др.…”

Section: отношения и деятельность: нетunclassified

“…Миокардиальный фиброз является важнейшим компонентом аритмогенеза как в случае верифицированной ишемии миокарда, так и при неишемической кардиомиопатии [7,11]. Возникающая вследствие острой ишемии и/или активного воспаления травма кардиомиоцитов инициирует структурное и функциональное ремоделирование миокарда с исходом в гипертрофию и/или замещение экстрацелюлярного матрикса соединительной тканью [15].…”

Section: анатомический и электрофизиологический субстрат вссunclassified

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Risk stratification of sudden cardiac death in heart failure patients: is left ventricular ejection fraction alone sufficient?

et al. 2021

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Илов Н. Н.*-к.м.н., доцент кафедры сердечно-сосудистой хирургии, врачсердечно-сосудистый хирург отделения хирургического лечения сложных нарушений ритма сердца и электрокардиостимуляции, ORCID: 0000-0003-1294-9646, Пальникова О. В.-врач-кардиолог отделения хирургического лечения сложных нарушений ритма сердца и электрокардиостимуляции, ORCID: 0000-0002-4476-5174, Стомпель Д. Р.-зав. отделением функциональной диагностики, ORCID: 0000-0002-2400-8045, Николаева Е. В.-зав. отделением лучевой диагностики, ORCID: 0000-0001-5701-2449, Нечепуренко А. А.-к.м.н., зав. отделением хирургического лечения сложных нарушений ритма сердца и электрокардиостимуляции, ORCID: 0000-0001-5722-9883.

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Section: отношения и деятельность: нетunclassified

Section: анатомический и электрофизиологический субстрат вссunclassified

Risk stratification of sudden cardiac death in heart failure patients: is left ventricular ejection fraction alone sufficient?

et al. 2021

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“…Failing heart is characterized by mechanical (systolic or diastolic) dysfunction and by electrical instability that aggravates overtime. This promotes sudden cardiac death attributed to ventricular brillation (VF) 2,[4][5][6][7] . The key factors facilitating such life-threatening event are myocardial structural remodelling, hypertrophy, brosis along with altered topology and disorders of connexin-43 (Cx43) channels [8][9][10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

Impact of volume overload on cardiac connexin-43 and extracellular matrix of normotensive and hypertensive Ren-2 transgenic rats: Effects of treatment with Trandolapril and Losartan

Sykora,

Kratky,

Červenka

et al. 2023

Preprint

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Heart failure (HF) is life-threatening disease due to electro-mechanical dysfunction associated with hemodynamic overload, while alterations of extracellular matrix (ECM) along with perturbed connexin-43 (Cx43) might be key factors involved. We aimed to explore an impact of volume overload due to aorto-caval fistula (ACF) on Cx43 and ECM as well as effect of renin-angiotensin blockade. Hypertensive Ren-2 transgenic rats (TGR) and normotensive Hannover Sprague–Dawley rats (HSD) that underwent ACF were treated for 15-weeks with Trandolapril or Losartan. Blood serum and heart tissue samples of the right (RV) and left ventricles (LV) were used for analyses. ACF-HF increased RV and LV mass in HSD and to lesser extent in TGR, while treatment attenuated it and normalized serum ANP and TBARS. Cx43 protein and its ser368 variant along PKCε were lower in TGR vs HSD and suppressed in both rat strains due to ACF but prevented more by trandolapril. Pro-hypertrophic PKCδ, collagen I and hydroxyproline were elevated in TGR and increased due to ACF in both rat strains. While Smad2/3 and MMP2 levels were lower in TGR vs HSD and reduced due to ACF in both strains. Findings point out the strain-related differences in response to volume overload. While disorders of Cx43 and ECM signalling may contribute not only to HF but also to malignant arrhythmia risk. There is benefit of treatment with trandolapril and losartan indicating their pleitropic antiarrhytmic potential. It may provide novel input to therapy.

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“…5,6,7 There have been some pharmacological and nonpharmacological techniques recommended for post operative atrial fibrillation (POAF) after CABG. 8,9…”

Section: Introductionmentioning

confidence: 99%

Role of Prophylactic Use of Amiodarone to Prevent Post-Operative Dysrhythmias in Patients with Low Ejection Fraction (EF ≤35%)

Ali

Qureshi³

2022

J Islamabad Med Dental Coll

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ABSTRACT: Objective: To determine the role of amiodarone prophylaxis in the prevention of dysrhythmias following coronary artery bypass grafting (CABG) in patients with low ejection fraction (EF). Methods: In this prospective comparative study, we included150 patients who underwent coronary artery bypass grafting (CABG) in Multan Institute of Cardiology within a duration of 07 months from Jan-2019 to Aug-2019 having low ejection fraction (EF ≤35%). In the intervention(amiodarone) group (N=75), 3 mg/Kg of amiodarone was given after removal of X-clamp and before weaning from cardiopulmonary bypass. while in the remaining 75 patients no anti-arrhythmic treatment was given in the peri-operative period. Occurrence of postoperative arrhythmia (AF and bradycardia) during the primary hospital stay after surgery was a primary study endpoint. Results: There was no significant difference between the mean age, gender and body mass index (BMI) of patients in the two groups. Regarding per-operative data, there was no significant difference in number of grafts in amiodarone group 3.9±0.53 and control group 3.04±0.50 (p-value 0.20). Frequency of Atrial fibrillation (AF) after the surgery was significantly differenced in both groups. In the amiodarone group, 13 (17.3%) patients developed POAF and in the control group, POAF occurred in 25 (33.3%) patients (p-value 0.024). Conclusion: Amiodarone prophylaxis significantly lower the incidence of POAF after CABG in patients with low EF. Amiodarone is easy to administer and is a valuable adjuvant for prevention of POAF.

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Defibrillator and non-ischaemic dilated cardiomyopathy: a never ending story

Cited by 6 publications

References 7 publications

Risk stratification of sudden cardiac death in heart failure patients: is left ventricular ejection fraction alone sufficient?

Risk stratification of sudden cardiac death in heart failure patients: is left ventricular ejection fraction alone sufficient?

Impact of volume overload on cardiac connexin-43 and extracellular matrix of normotensive and hypertensive Ren-2 transgenic rats: Effects of treatment with Trandolapril and Losartan

Role of Prophylactic Use of Amiodarone to Prevent Post-Operative Dysrhythmias in Patients with Low Ejection Fraction (EF ≤35%)

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