Defensive effects of a fucoidan from brown alga Undaria pinnatifida against herpes simplex virus infection

Hayashi, Kyoko; Nakano, Takahisa; Hashimoto, Masatomo; Kanekiyo, Kenji; Hayashi, Toshimitsu

doi:10.1016/j.intimp.2007.10.017

Cited by 222 publications

(156 citation statements)

References 51 publications

(55 reference statements)

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“…24) As mentioned above, we also found that Mekabu extract supported in vitro growth of spleen lymphocytes. However, it was still unclear if fucoidan directly stimulated B lymphocytes to proliferate and secrete Ig because spleen lymphocytes consist of multiple types of immune cells such as monocytes, granulocytes, T lymphocytes and B lymphocytes, and so on.…”

supporting

confidence: 71%

The enhancing effect of fucoidan derived from Undaria pinnatifida on immunoglobulin production by mouse spleen lymphocytes

Takai

Miyazaki

Tachibana

et al. 2014

Bioscience, Biotechnology, and Biochemistry

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supporting

confidence: 71%

The enhancing effect of fucoidan derived from Undaria pinnatifida on immunoglobulin production by mouse spleen lymphocytes

Takai

Miyazaki

Tachibana

et al. 2014

Bioscience, Biotechnology, and Biochemistry

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“…Although it is not possible to determine whether only one or a combination of several molecules are responsible for the observed anti-HSV-1 and anti-HSV-2 activity of the extracts, the presence of terpenes, fatty acids and phenolic compounds is consistent with the observed anti-herpetic activity since these types of metabolites, isolated from marine and terrestrial sources, have already been shown to have anti-herpetic activity (Khan et al, 2005;Hayashi et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Antiviral activity of extracts from Brazilian seaweeds against herpes simplex virus

Soares¹,

Robaina²,

Mendes³

et al. 2012

Rev. bras. farmacogn.

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Organic extracts of 36 species of marine algae (sixteen species of Rhodophyta, eight species of Ochrophyta and twelve species of Chlorophyta) from seven locations on the Brazilian coast were evaluated for their anti-HSV-1 and anti-HSV-2 activity resistant to Acyclovir (ACV). Activity tests in crude extracts, followed by the identification of the major compounds present, were performed for all species. The chemical profiles of all crude extracts were obtained by 1 H-NMR and 13 C-NMR spectroscopy. The percentage of extracts with antiviral activity was higher for HSV-1 (86.1%) than for HSV-2 (55.5%). The green algae Ulva fasciata and Codium decorticatum both showed the highest activity (99.9%) against HSV-1, with triacylglycerols and fatty acids as the major components. The red alga Laurencia dendroidea showed good activity against HSV-1 (97.5%) and the halogenated sesquiterpenes obtusol and (-)-elatol were identified as the major components in the extract. Against HSV-2, the green alga Penicillus capitatus (Chlorophyta) and Stypopodium zonale (Ochrophyta) were the most active (96.0 and 95.8%). Atomaric acid, a meroditerpene, was identified as the major secondary metabolite in the S. zonale extract. These results reinforce the role of seaweeds as important sources of compounds with the potential to enter into the pipeline for development of new drugs against herpes simplex.

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“…52 Furthermore, when we infected HCECs with a low MOI of 0.1 to examine the effect of the gycopolymer 9 on viral spreading, we showed that the sulfated glycopolymer (as well as heparin, dextran sulfate, and natural fucoidan) was able to HCEC nuclei were stained with DAPI (blue). Nontreated HCECs (e) are displayed as references.…”

Section: Synthetic Glycopolymers Block Hsv-1 Activity During the Virumentioning

confidence: 97%

Synthesis and Biological Evaluation of Fucoidan-Mimetic Glycopolymers through Cyanoxyl-Mediated Free-Radical Polymerization

Tengdelius¹,

Lee²,

Grenegård

et al. 2014

Biomacromolecules

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The sulfated marine polysaccharide fucoidan has been reported to have health benefits ranging from antivirus and anticancer properties to modulation of high blood pressure. Hence, they could enhance the biological function of materials for biomedical applications. However, the incorporation of fucoidan into biomaterials has been difficult, possibly due to its complex structure and lack of suitable functional groups for covalent anchoring to biomaterials. We have developed an approach for a rapid synthesis of fucoidan-mimetic glycopolymer chains through cyanoxyl-mediated free-radical polymerization, a method suitable for chain-end functionalizing and subsequent linkage to biomaterials. The resulting sulfated and nonsulfated methacrylamido α-L-fucoside glycopolymers' fucoidan-mimetic properties were studied in HSV-1 infection and platelet activation assays. The sulfated glycopolymer showed similar properties to natural fucoidan in inducing platelet activation and inhibiting HSV-1 binding and entry to cells, thus indicating successful syntheses of fucoidan-mimetic glycopolymers.

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Defensive effects of a fucoidan from brown alga Undaria pinnatifida against herpes simplex virus infection

Cited by 222 publications

References 51 publications

The enhancing effect of fucoidan derived from Undaria pinnatifida on immunoglobulin production by mouse spleen lymphocytes

The enhancing effect of fucoidan derived from Undaria pinnatifida on immunoglobulin production by mouse spleen lymphocytes

Antiviral activity of extracts from Brazilian seaweeds against herpes simplex virus

Synthesis and Biological Evaluation of Fucoidan-Mimetic Glycopolymers through Cyanoxyl-Mediated Free-Radical Polymerization

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