The enhancing effect of fucoidan derived from <i>Undaria pinnatifida</i> on immunoglobulin production by mouse spleen lymphocytes

Takai, Mika; Miyazaki, Y.; Tachibana, Hirofumi; Yamada, Koji

doi:10.1080/09168451.2014.930323

Cited by 15 publications

(10 citation statements)

References 24 publications

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“…Fucoidan’s immunomodulatory effects have been reported in different experimental models. It has been shown to activate and promote the maturation of human monocyte-derived dendritic cells [17], and stimulate lymphocyte [18,19] and macrophage activity [18,20] in vitro. According to Do et al [21], fucoidan is an immunomodulating nutrient which alters the sensitivity of glia and macrophages.…”

Section: Introductionmentioning

confidence: 99%

Dietary Supplementation with Low-Molecular-Weight Fucoidan Enhances Innate and Adaptive Immune Responses and Protects against Mycoplasma pneumoniae Antigen Stimulation

Hwang

Lin

Lo³

2019

Marine Drugs

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In this study, the low-molecular-weight (LMW) fucoidan, rich in fucose and sulfate, was extracted and purified from the edible brown seaweed, Laminaria japonica. In this study, we orally administered LMW fucoidan to mice for 6 weeks. We then examined fucoidan’s effects on innate immunity, adaptive immunity, and Mycoplasma pneumoniae (MP)-antigen-stimulated immune responses. Our data showed that LMW fucoidan stimulated the innate immune system by increasing splenocyte proliferation, natural killer (NK) cell activity, and phagocytic activity. LMW fucoidan also increased interleukin (IL)-2, IL-4, and interferon (IFN)-γ secretion by splenocytes and immunoglobulin (Ig)-G and IgA content in serum, which help regulate adaptive immune cell functions, and decreased allergen-specific IgE. In MP-antigen-stimulated immune responses, the IgM and IgG content in the serum were significantly higher in the LMW fucoidan group after MP-antigen stimulation. Our study provides further information about the immunomodulatory effects of LMW fucoidan and highlights a potential role in preventing M. pneumoniae infection.

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Section: Introductionmentioning

confidence: 99%

Dietary Supplementation with Low-Molecular-Weight Fucoidan Enhances Innate and Adaptive Immune Responses and Protects against Mycoplasma pneumoniae Antigen Stimulation

Hwang

Lin

Lo³

2019

Marine Drugs

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“…Numerous studies have demonstrated that fucoidan has anticancer effects, which are mainly caused by an inhibition of cancer cell growth and promotion of antitumor cytokine secretion, as well as lymphocyte proliferation [17,18]. It has also been reported that fucoidan induces apoptosis and cell cycle arrest in a variety of cancer cell types, including leukemia, hepatocellular carcinoma, prostate cancer, breast cancer and bladder cancer [19,20,21,22,23,24].…”

Section: Introductionmentioning

confidence: 99%

Induction of p53-Independent Apoptosis and G1 Cell Cycle Arrest by Fucoidan in HCT116 Human Colorectal Carcinoma Cells

Park

Jeong

et al. 2017

Marine Drugs

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Abstract:It is well known that fucoidan, a natural sulfated polysaccharide present in various brown algae, mediates anticancer effects through the induction of cell cycle arrest and apoptosis. Nevertheless, the role of tumor suppressor p53 in the mechanism action of fucoidan remains unclear. Here, we investigated the anticancer effect of fucoidan on two p53 isogenic HCT116 (p53+/+ and p53−/−) cell lines. Our results showed that inhibition of cell viability, induction of apoptosis and DNA damage by treatment with fucoidan were similar in two cell lines. Flow cytometric analysis revealed that fucoidan resulted in G1 arrest in the cell cycle progression, which correlated with the inhibition of phosphorylation of retinoblastoma protein (pRB) and concomitant association of pRB with the transcription factor E2Fs. Furthermore, treatment with fucoidan obviously upregulated the expression of cyclin-dependent kinase (CDK) inhibitors, such as p21WAF1/CIP1 and p27KIP1, which was paralleled by an enhanced binding with CDK2 and CDK4. These events also commonly occurred in both cell lines, suggesting that fucoidan triggered G1 arrest and apoptosis in HCT116 cells by a p53-independent mechanism. Thus, given that most tumors exhibit functional p53 inactivation, fucoidan could be a possible therapeutic option for cancer treatment regardless of the p53 status.

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“…Fucoidan can target multiple receptors, such as scavenger receptors, or signaling molecules in various cell types, including tumor cells and immune cells 13 14 . Numerous studies have shown that fucoidan has antitumor effect which is mainly manifested as inhibition of tumor cell growth and migration, promoting lymphocyte proliferation and antitumor cytokine secretion 15 16 17 . Our previous studies have shown that fucoidan induce a functional maturation of human monocyte-derived dendritic cells 18 and inhibit monocytes-induced angiogenesis 19 .…”

mentioning

confidence: 99%

Fucoidan inhibits CCL22 production through NF-κB pathway in M2 macrophages: a potential therapeutic strategy for cancer

Sun

Song

Zhang

et al. 2016

Sci Rep

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In tumor microenvironment, macrophages as a polarized M2 population promote tumor progression via releasing multiple cytokines and chemokines. A brown seaweed fucose-rich polysaccharide, fucoidan has antitumor activity and immune modulation through affecting tumor cells and lymphocytes. Here, we focused on the effect of fucoidan on macrophages especially M2 subtype. Our results demonstrated that fucoidan down-regulated partial cytokines and chemokines, especially a M2-type chemokine CCL22. Furthermore, fucoidan inhibited tumor cells migration and CD4+ T lymphocytes, especially Treg cells, recruitment induced by M2 macrophages conditioned medium through suppression of CCL22. Mechanismly, fucoidan inhibited CCL22 via suppressing p65-NF-κB phosphorylation and nuclear translocation. In addition, p38-MAPK and PI3K-AKT also affected the expression of CCL22 through differential modulation of NF-κB transcriptional activity. Taken together, we reveal an interesting result that fucoidan can inhibit tumor cell migration and lymphocytes recruitment by suppressing CCL22 in M2 macrophages via NF-κB-dependent transcription, which may be a novel and promising mechanism for tumor immunotherapy.

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The enhancing effect of fucoidan derived from Undaria pinnatifida on immunoglobulin production by mouse spleen lymphocytes

Cited by 15 publications

References 24 publications

Dietary Supplementation with Low-Molecular-Weight Fucoidan Enhances Innate and Adaptive Immune Responses and Protects against Mycoplasma pneumoniae Antigen Stimulation

Dietary Supplementation with Low-Molecular-Weight Fucoidan Enhances Innate and Adaptive Immune Responses and Protects against Mycoplasma pneumoniae Antigen Stimulation

Induction of p53-Independent Apoptosis and G1 Cell Cycle Arrest by Fucoidan in HCT116 Human Colorectal Carcinoma Cells

Fucoidan inhibits CCL22 production through NF-κB pathway in M2 macrophages: a potential therapeutic strategy for cancer

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