Defensins Impair Phagocytic Killing by Neutrophils in Biomaterial-Related Infection

Kaplan, Sandra S.; Heine, R. Phillips; Simmons, Richard L.

doi:10.1128/iai.67.4.1640-1645.1999

Cited by 38 publications

(3 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Macrophages can produce osteoblast activity factors such as BMP-2 and TGF-b (2). During wear debris-induced periprosthetic osteolysis, the macrophages are recruited to the local site (13,32,44). In contrast, bone tissue-resident macrophages (OsteoMacs), essential in directing osteoblast function/ mineralization, have not been studied during AL (2).…”

Section: Osteoblasts: a Contributor To Bone Resorptionmentioning

confidence: 99%

Roles of inflammatory cell infiltrate in periprosthetic osteolysis

Panez-Toro,

Heymann,

Gouin

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Classically, particle-induced periprosthetic osteolysis at the implant–bone interface has explained the aseptic loosening of joint replacement. This response is preceded by triggering both the innate and acquired immune response with subsequent activation of osteoclasts, the bone-resorbing cells. Although particle-induced periprosthetic osteolysis has been considered a foreign body chronic inflammation mediated by myelomonocytic-derived cells, current reports describe wide heterogeneous inflammatory cells infiltrating the periprosthetic tissues. This review aims to discuss the role of those non-myelomonocytic cells in periprosthetic tissues exposed to wear particles by showing original data. Specifically, we discuss the role of T cells (CD3+, CD4+, and CD8+) and B cells (CD20+) coexisting with CD68+/TRAP− multinucleated giant cells associated with both polyethylene and metallic particles infiltrating retrieved periprosthetic membranes. This review contributes valuable insight to support the complex cell and molecular mechanisms behind the aseptic loosening theories of orthopedic implants.

show abstract

Section: Osteoblasts: a Contributor To Bone Resorptionmentioning

confidence: 99%

Roles of inflammatory cell infiltrate in periprosthetic osteolysis

Panez-Toro,

Heymann,

Gouin

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Ведущая роль S. aureus и S. epidermidis в этиологии ортопедической ППИ во многом обусловлена способностью быстро формировать многоуровневые микробные биопленки на поверхности искусственных имплантатов [8,9]. Существование возбудителей в составе биопленок затрудняет диагностику ППИ и снижает эффективность антибактериальной терапии, в том числе препаратами, высокоактивными в отношении метициллин-резистентных стафилококков [10,12,13].…”

Section: резюме _____________________________________________________...unclassified

Periprosthetic Infection: Approaches to Antibacterial Therapy

Талако,

Абельская,

Слободин

et al. 2023

Рецепт

View full text Add to dashboard Cite

Перипротезная инфекция суставов (ППИ) является одним из наиболее разрушительных и дорогостоящих осложнений после тотального эндопротезирования суставов (ТЭС). Диагностика и лечение ППИ является сложной задачей для врачей-ортопедов. Не существует «золотого стандарта» диагностики ППИ. Бывает достаточно сложно разобраться между септическими и асептическими нарушениями. Кроме того, некоторые из самых больших трудностей и противоречий связаны с выбором оптимального метода лечения инфицированного сустава. До сих пор ведутся серьезные дебаты относительно идеальной стратегии лечения ППИ, что привело к значительным международным различиям как в хирургическом, так и в нехирургическом лечении ППИ. Инфекция, связанная с артропластикой, или перипротезная инфекция сустава, является редким заболеванием и клинически отличается от инфекции нативной кости или сустава. ППИ предполагает взаимодействие между микроорганизмами, с одной стороны, и имплантатом и иммунной системой хозяина, с другой. Небольшое количество микроорганизмов может вызвать ППИ. Бактерии (и в редких случаях грибы) прикрепляются к поверхностям протезированного сустава и образуют биопленки. Биопленки, как правило, устойчивы ко многим противомикробным агентам и иммунной системе хозяина. Возбудителями может быть микробиота кожи, инокулированная при установке протеза. Periprosthetic joint infection (PJI) is one of the most devastating and costly complications following total joint arthroplasty (TJA). Diagnosis and treatment of PJI is a challenging task for orthopedic physicians. There is no gold standard for diagnosing PJI. It can be quite difficult to understand between septic and aseptic disorders. Additionally, some of the greatest difficulties and controversies involve choosing the optimal treatment method for an infected joint. There is still considerable debate regarding the ideal treatment strategy for PJI, which has led to significant international variation in both surgical and non-surgical treatment of PJI. Arthroplasty-associated infection, or periprosthetic joint infection, is a rare condition and clinically distinct from infection of the native bone or joint. PPI involves an interaction between microorganisms, on the one hand, and the implant and the host’s immune system, on the other. A small number of microorganisms can cause PJI. Bacteria (and in rare cases fungi) attach to the surfaces of the prosthetic joint and form biofilms. Biofilms are generally resistant to many antimicrobial agents and the host immune system. Pathogens may be skin microbiota inoculated during installation of the prosthesis.

show abstract

“…The behaviors of neutrophil adhesion to biomaterials are determined by surface chemistry [ 239 ], topography [ 240 ], wettability [ 241 ], and stiffness [ 242 ]. Polystyrene and woven Dacron or Silastic induced neutrophil release of granule antibacterial products (are cationic peptides known as defensins) to create an environment hostile to phagocytic killing by neutrophils [ 243 ]. Polytetrafluoroethylene and Dacron promoted the production of ROS and mediated premature neutrophil death while polystyrene did not [ 239 ].…”

Section: Innovative Designs To Mitigate Device-associated Infectionsmentioning

confidence: 99%

Antibacterial Designs for Implantable Medical Devices: Evolutions and Challenges

Cao

Qiao

Qin

2022

JFB

View full text Add to dashboard Cite

The uses of implantable medical devices are safer and more common since sterilization methods and techniques were established a century ago; however, device-associated infections (DAIs) are still frequent and becoming a leading complication as the number of medical device implantations keeps increasing. This urges the world to develop instructive prevention and treatment strategies for DAIs, boosting the studies on the design of antibacterial surfaces. Every year, studies associated with DAIs yield thousands of publications, which here are categorized into four groups, i.e., antibacterial surfaces with long-term efficacy, cell-selective capability, tailored responsiveness, and immune-instructive actions. These innovations are promising in advancing the solution to DAIs; whereas most of these are normally quite preliminary “proof of concept” studies lacking exact clinical scopes. To help identify the flaws of our current antibacterial designs, clinical features of DAIs are highlighted. These include unpredictable onset, site-specific incidence, and possibly involving multiple and resistant pathogenic strains. The key point we delivered is antibacterial designs should meet the specific requirements of the primary functions defined by the “intended use” of an implantable medical device. This review intends to help comprehend the complex relationship between the device, pathogens, and the host, and figure out future directions for improving the quality of antibacterial designs and promoting clinical translations.

show abstract

Defensins Impair Phagocytic Killing by Neutrophils in Biomaterial-Related Infection

Cited by 38 publications

References 66 publications

Roles of inflammatory cell infiltrate in periprosthetic osteolysis

Roles of inflammatory cell infiltrate in periprosthetic osteolysis

Periprosthetic Infection: Approaches to Antibacterial Therapy

Antibacterial Designs for Implantable Medical Devices: Evolutions and Challenges

Contact Info

Product

Resources

About