The aim of this study was to analyze the nutritional status of patients with Down Syndrome (DS) and congenital heart defect (CHD). A transversal study which assessed the nutritional profile of DS and CHD patients between 0 and 18 years of age was done. Weight and stature, both at birth and current were considered. A total of 98 patients, 56% female were analyzed. Prevalence of low weight, overweight and low stature at the current anthropometric data (CAD) was 30%, 22% and 17%, respectively. There was a statistically significant difference between malnutrition at birth and the CAD (p<0.01). The current weight/age (W/A) ratio showed significant increase as compared to birth W/A (p=<0.05). In addition, there was also stature recovery based on stature/age (S/A) ratio (p<0,001). In conclusion, at birth, these patients present stature and weight deficit but as age advances there is a stature improvement; however it is not properly accompanied by the weight, since there is a tendency towards overweight in puberty.