Defective aggregation in cirrhosis is independent of in vivo platelet activation

Cinotti, S.; Filimberti, Ermino; Ciabattoni, Giovanni; Caporale, Roberto; Marra, Fabio; Melani, Lorenzo; Grossi, Alberto; Carloni, Vinicio; Geñtilini, Paolo

doi:10.1016/s0168-8278(96)80164-4

Cited by 35 publications

(38 citation statements)

References 38 publications

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“…The urinary excretion rate of 11-dehydro-TXB 2 was also significantly higher in cirrhotic patients than in control subjects, confirming previous data from our group [33] and other investigators [34]. The mechanisms underlying the increase in 11-dehydro-TXB 2 during cirrhosis are still unclear, although altered hepatic TXA 2 metabolism, increased intrasplenic platelet destruction and in vivo platelet activation may affect TXA 2 entry into systemic circulation [33].…”

Section: Table 2 Plasma Lipids (A) and Phospholipids (B) And Rbc (C) supporting

confidence: 88%

Effects of dietary supplementation with arachidonic acid on platelet and renal function in patients with cirrhosis

et al. 2004

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Advanced cirrhosis is associated with reduced platelet function and altered renal function and sodium handling. Arachidonic acid (AA) metabolites contribute to platelet aggregation and to maintain the response to diuretics in advanced cirrhosis. In the present study, we tested the effects of a dietary supplementation for 8 weeks with a triacylglycerol (triglyceride) enriched in AA (ARASCO; 4 g/day) or oleic acid (OA) on plasma and membrane fatty acid composition, platelet aggregation and renal prostaglandin (PG) metabolism. At baseline, all patients had reduced platelet aggregation. Patients treated with AA showed a significant increase in the percentage of AA in plasma lipids and membrane phospholipids. These changes were associated with an increased platelet aggregation in response to collagen (from 55.83 +/- 20.63 to 67.67 +/- 14.44%; P<0.05). At baseline, all urinary AA metabolites, including PGE2, 6-keto-PGF1alpha, 8-epi-PGF2alpha and 11-dehydro-thromboxane B2, were elevated in cirrhotic patients when compared with a group of normal subjects. After furosemide treatment, urinary excretion of 11-dehydro-thromboxane B2 increased significantly. Supplementation with AA did not result in any significant change in urinary PG excretion either before or after diuretic administration. The results of the present study show that dietary supplementation with AA effectively increases the levels of this fatty acid in plasma and membrane phospholipids and improves platelet aggregation. These data suggest a possible novel approach to the treatment of the haemostatic defect observed in these patients.

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Section: Table 2 Plasma Lipids (A) and Phospholipids (B) And Rbc (C) supporting

confidence: 88%

Effects of dietary supplementation with arachidonic acid on platelet and renal function in patients with cirrhosis

et al. 2004

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“…In particular, reports in the literature disagree on the occurrence of in vivo platelet activation in patients with chronic liver disease. Laffi and coworkers, 5 in fact, suggested that the defective platelet aggregation found in cirrhotic patients is a result of alteration of the transmembrane signaling pathways and that increased urinary excretion of thromboxane A2 may be related to increased intrasplenic platelet destruction. Conversely, Davì et al 6 found a significant correlation between urinary excretion of 2,3-dinor-thromboxane B2 and plasma prothrombin fragment 1+2 (F1+2), suggesting that clotting activation could partly account for in vivo platelet activation in cirrhotic patients.…”

Section: Introductionmentioning

confidence: 99%

Increased Soluble P-Selectin Levels in Hepatitis C Virus-Related Chronic Hepatitis: Correlation with Viral Load

Ferroni

Mammarella

Martini

et al. 2001

Journal of Investigative Medicine

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“…In the current study, liver function tests (such as total bilirubin) normalized or improved following liver transplantation. Experimental and clinical data have established a direct relationship between functional liver mass and peripheral platelet counts [31][32][33][34]. In the current study, OLT reduced portal pressure and restored liver function resulting in a rapid resolution of thrombocytopenia.…”

Section: Discussionmentioning

confidence: 53%

Immature platelet fraction values predict recovery of platelet counts following liver transplantation

Mao

Lou

et al. 2015

Clinics and Research in Hepatology and Gastroenterology

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Defective aggregation in cirrhosis is independent of in vivo platelet activation

Cited by 35 publications

References 38 publications

Effects of dietary supplementation with arachidonic acid on platelet and renal function in patients with cirrhosis

Effects of dietary supplementation with arachidonic acid on platelet and renal function in patients with cirrhosis

Increased Soluble P-Selectin Levels in Hepatitis C Virus-Related Chronic Hepatitis: Correlation with Viral Load

Immature platelet fraction values predict recovery of platelet counts following liver transplantation

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