Defect-rich titanium nitride nanoparticle with high microwave-acoustic conversion efficiency for thermoacoustic imaging-guided deep tumor therapy

Wu, Zhujun; Zeng, Fanchu; Zhang, Le; Zhao, Shufan; Wu, Linghua; Qin, Huan; Xing, Da

doi:10.1007/s12274-020-3277-8

Cited by 15 publications

(12 citation statements)

References 57 publications

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“…Fe 3 O 4 [25] ) and dual-mechanism loss nanoprobes ( e.g. defect-rich titanium nitride [26] , Fe-filled carbon nanotube [27] , etc. ) have good microwave-acoustic conversion efficiency due to their unique electromagnetic properties.…”

Section: Introductionmentioning

confidence: 99%

Manganous-manganic oxide nanoparticle as an activatable microwave-induced thermoacoustic probe for deep-located tumor specific imaging in vivo

Zhang

Chen

et al. 2022

Photoacoustics

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Section: Introductionmentioning

confidence: 99%

Manganous-manganic oxide nanoparticle as an activatable microwave-induced thermoacoustic probe for deep-located tumor specific imaging in vivo

Zhang

Chen

et al. 2022

Photoacoustics

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“…This confined heat results in thermoelastic expansion and then produces shockwaves via thermal acoustic cavitation. [ 30–33,48,49 ]…”

Section: Introductionmentioning

confidence: 99%

“…[1,2] Current standards of care include surgical resection followed by radiotherapy and longer wavelengths than the optical region. [28][29][30] The use of pulsed microwaves rather than pulsed lasers can activate nanoparticles to generate acoustic shockwaves. Thus, pulsed microwave-induced thermoacoustic (MTA) therapy is an effective method for the precise treatment of tumors in deep tissue.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, pulsed microwave-induced thermoacoustic (MTA) therapy is an effective method for the precise treatment of tumors in deep tissue. [30][31][32][33] Several potential advantages are provided by this technology: 1) It breaks through the treatment depth limit of phototherapies and photoacoustic therapy. 2) Compared with the slower temperature dispersion in microwave hyperthermia, the effective impact range of microwave-induced thermoacoustic shockwave is well defined due to the rapid attenuation of shockwave intensity in the target tissue (about tens of micrometers).…”

Section: Introductionmentioning

confidence: 99%

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Pulsed Microwave‐Induced Thermoacoustic Shockwave for Precise Glioblastoma Therapy with the Skin and Skull Intact

Zhang

Xing

et al. 2022

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chemotherapy. [2][3][4] Glioblastoma usually invades the brain tissue in a radiative way and has no definite boundary; thus, complete neurosurgical resection is rarely achieved. [2,[4][5][6] Postoperative adjuvant conventional radiotherapy and chemotherapy are limited by intratumoral hypoxia, inadequate ability of drugs to cross the bloodbrain barrier (BBB), drug resistance, and serious side effects. [7][8][9] The median survival remains <15 months, [7][8][9][10][11] and new therapeutic strategies are desperately needed.Phototherapies with localized treatment and reduced side effects are alternative promising modalities for glioblastoma treatment. Phototherapy involves laser absorption by a photosensitizer to generate photochemical reaction as in photodynamic therapy (PDT) [11][12][13][14][15] or to generate localized hyperthermia as in photothermal therapy (PTT). [16][17][18][19] Unfortunately, oxygendependent PDT does not have good therapeutic efficacy on hypoxic tumors. [11,18] PTT can cause thermal diffusion and can damage surrounding normal cells, [19] thus yielding impaired brain function. High-efficiency and precise glioblastoma treatment methods are still urgently needed.We recently demonstrated that pulsed laser induced ultrasonic shockwaves (photoacoustic therapy, PA therapy) can selectively destroy glioblastoma tumors with no observable side effects on normal tissue. [16,[20][21][22] In PA therapy, nano particles in targeted tumor cells can absorb energy of pulsed laser and transferred into ultrasonic shockwaves via photoacoustic cavitation. [23,24] The shockwave intensity decays rapidly from the target tissue (approximately tens of micrometers), [25] and thus PA shockwave can cause minimal damage to normal cells around tumor and realize local mechanical damage to tumor cells. PA therapy overcomes the shortcomings of PTT: There is reduced thermal damage to surrounding tissue. PA therapy is also not limited by hypoxia in the tumor microenvironment like PDT. PA therapy presents unique advantages in the precise and efficient treatment of glioblastoma. However, PA therapy is usually limited by light penetration depth due to the strong optical scattering of biological tissues, thus making it difficult to achieve effective treatment of glioblastoma with intact skin and skull. [17,26,27] Microwave scattering in soft tissue is three orders of magnitude weaker than optical scattering because microwaves have Glioblastoma has a dismal prognosis and is a critical and urgent health issue that requires aggressive research and determined clinical efforts. Due to its diffuse and infiltrative growth in the brain parenchyma, complete neurosurgical resection is rarely possible. Here, pulsed microwave-induced thermoacoustic (MTA) therapy is proposed as a potential alternative modality to precisely and effectively eradicate in vivo orthotopic glioblastoma. A nanoparticle composed of polar amino acids and adenosine-based agonists is constructed with high microwave absorbance and selective penetration of the blood-brain barr...

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“…It proves the sub‐millimeter resolution. Using nanoparticles as a contrast agent, TA imaging can reconstruct images and monitor tumor size, shape and location 18 . This paper proposes a high‐resolution imaging method for reconstructing MNPs, which is expected to achieve large‐depth tumor imaging and lays a theoretical foundation for the further development.…”

Section: Introductionmentioning

confidence: 99%

Thermoacoustic tomography from magnetic nanoparticles by single‐pulse magnetic field

Liu

2021

Medical Physics

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Purpose A mechanism of single‐pulse magnetic field (SMF) inducing magnetic nanoparticles (MNPs) to generate the thermoacoustic (TA) wave is proposed, and its feasibility is proved by simulation and experiment. Methods According to the principle of dimensional consistency, it is proposed that the internal energy variation of MNPs under the adiabatic condition mainly stems from the accumulation of magnetization energy, which leads to the magnetothermal effect, and then the TA wave is excited by thermal expansion. The analytical model of the forward problem is derived based on the method of space‐time separation. The magnetization curve of MNPs is obtained from Langevin theory, and a three‐dimension simulation model based on the magnetization curve is established to analyze the generation process of the TA wave. In the Experimental section, a gel phantom with a 0.5 mm gap is prepared with the magnetic fluid injecting into the gap, and the cross‐sectional image of the gel phantom is reconstructed by the image fusion algorithm based on B‐scan imaging. Results The simulation analysis shows that the generated TA signal can reflect the boundary information of the MNPs region, and when the MNPs are in the unsaturated magnetized region, the intensity of the TA signal is positively correlated with the concentration of MNPs. The B‐scan imaging along the X‐axis and Y‐axis directions are obtained through the experimental data. After that, the phantom with 0.5 mm gap labeled by MNPs is faithfully reconstructed by combining image morphology processing and image fusion technology based on wavelet transform. Conclusions The results show that the TA tomography from MNPs by SMF uses MNPs as a contrast agent to reconstruct the size and shape of the marked phantom with submillimeter resolution, which is expected to reconstruct the image of the tumor labeled by MNPs in the future. However, it is also a certain challenge to use low‐concentration MNPs to image in vivo.

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Defect-rich titanium nitride nanoparticle with high microwave-acoustic conversion efficiency for thermoacoustic imaging-guided deep tumor therapy

Cited by 15 publications

References 57 publications

Manganous-manganic oxide nanoparticle as an activatable microwave-induced thermoacoustic probe for deep-located tumor specific imaging in vivo

Manganous-manganic oxide nanoparticle as an activatable microwave-induced thermoacoustic probe for deep-located tumor specific imaging in vivo

Pulsed Microwave‐Induced Thermoacoustic Shockwave for Precise Glioblastoma Therapy with the Skin and Skull Intact

Thermoacoustic tomography from magnetic nanoparticles by single‐pulse magnetic field

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