Manganous-manganic oxide nanoparticle as an activatable microwave-induced thermoacoustic probe for deep-located tumor specific imaging in vivo

Zhang, Shanxiang; Li, Wenjing; Chen, Xiaoyu; Ren, Mingyang; Zhang, Huimin; Xing, Da; Qin, Huan

doi:10.1016/j.pacs.2022.100347

Cited by 7 publications

(7 citation statements)

References 44 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The thermoacoustic imaging in vivo was according to the previous report. 62 Briefly, 1.2 GHz microwave generator was adjusted to transmit 0.5 μs microwave pulse with 10 Hz of repetition frequency and 250 kW of peak power. The microwave pumped through the waveguide with an effective radiation area 8.3 × 16.5 cm 2 .…”

Section: ■ Experimental Methodsmentioning

confidence: 99%

Thermoacoustic Imaging-Guided Thermo-Chemotherapy for Hepatocellular Carcinoma Sensitized by a Microwave-Responsive Nitric Oxide Nanogenerator

Wen

Liu

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Imaging-guided percutaneous microwave thermotherapy has been regarded as an important alternative nonsurgical therapeutic strategy for hepatocellular carcinoma (HCC) that provides excellent local tumor control and favorable survival benefit. However, providing a high-resolution, real-time, and noninvasive imaging technique for intraoperative guidance and controlling postoperative residual tumor recurrence are urgent needs for the clinical setting. In this study, a cisplatin (CDDP)-loaded nanocapsule (NPs@CDDP) with microwave responsive property was prepared to simultaneously serve as a contrast agent of emerging thermoacoustic imaging and a sensitizing agent of microwave thermo-chemotherapy. Accompanying the enzymolysis in the tumor microenvironment, the NPs@CDDP responsively release l-arginine (l-Arg) and CDDP. l-Arg with excellent microwave-absorbing property allowed it to serve as a thermoacoustic imaging contrast agent for accurately delineating the tumor and remarkably increasing tumor temperature under ultralow power microwave irradiation. Apart from the chemotherapeutic effect, CDDP elevated the intracellular H2O2 level through cascade reactions and further accelerated the continuous transformation of l-Arg to nitric oxide (NO), which endowed the NPs@CDDP with NO-generation capability. Notably, the high concentration of intracellular NO was proved to aggravate lipid peroxidation and greatly improved the efficacy of microwave thermo-chemotherapy. Thereby, NPs@CDDP was expected to serve as a theranostic agent integrating the functions of tumor microenvironment-responsive drug delivery system, contrast agent of thermoacoustic imaging, thermal sensitizing agent, and NO nanogenerator, which was promising to provide a potential imaging-guided therapeutic strategy for HCC.

show abstract

Section: ■ Experimental Methodsmentioning

confidence: 99%

Thermoacoustic Imaging-Guided Thermo-Chemotherapy for Hepatocellular Carcinoma Sensitized by a Microwave-Responsive Nitric Oxide Nanogenerator

Wen

Liu

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…Similarly, Sun et al [56] constructed a TME-responsive nanoplatform assembled by chlorine e6 (Ce6) modified carbon dots and Cu 2+ ions (named Cu/CC NPs). The Cu/CC NPs showed quenched fluorescence in the aggregation state by Cu 2+ MnO x -HMSN pH Dynamic T 1 -weighted MRI 2012 [ 33] DOX-mMnO 2 @ C1498 AML cell membrane pH and GSH Dynamic T 1 -weighted MRI 2023 [ 34] BSA/Mn-LDH pH Dynamic T 1 -weighted MRI 2017 [ 35] Iron oxide nano-grenade pH Dynamic T 1 -weighted MRI 2014 [ 38] PEG-USPIONs@CaCO 3 nanoprobe pH T 2 -T 1 Switchable MRI 2021 [ 39] Janus nanocomposite consisting of a MOF and UCNP H 2 O 2 and GSH Dynamic T 2 -weighted MRI 2021 [ 40] Cobalt Complexes (Co-TPA) Oxygen Dynamic T 1 and T 2 -weighted MRI 2016 [ 41] GGT activatable chemiluminescent probe GGT Dynamic Chemiluminescence imaging 2019 [ 44] AIE fluorophore (TPEQH) with a phosphate group ALP Dynamic FLI 2020 [ 49] Liposome-based probe pH Dynamic FLI 2020 [ 50] Afterglow luminescent AIE NP AST Dynamic afterglow luminescence imaging 2019 [ 51] Ag 2 S-QD Vesicles pH NIR-II FLI 2021 [ 55] Cu/CC NPs pH and GSH Dynamic FLI 2020 [ 56] Mn 3 O 4 -PEG-RGD NP pH and GSH Dynamic MTAI 2022 [ 57] Pd-Pep-BSA-CQ4T-Ag nano-system pH and H 2 O 2 Dynamic FLI and PAI 2022 [ 58] ions. This fluorescence signal recovered efficiently once Cu/CC NPs disassemble under the stimulation of TME.…”

Section: Tme-responsive Fli Contrast Agentsmentioning

confidence: 99%

“…In addition to the above-mentioned TME-responsive MRI and FLI contrast agents, other nanomaterials with signals changed by the TME can also monitor tumor accumulation. For example, Zhang et al [57] developed GSH and pH-responsive microwaveinduced thermoacoustic imaging (MTAI) contrast agents by using Mn 3 O 4 -PEG-RGD NPs (Figure 6a,b). These NPs released manganese ions and increased conductivity under acidic and high GSH environments, resulting in enhanced thermoacoustic signals by altering the thermo-acoustic conversion efficiency and microwave loss capacity.…”

Section: Other Tme-responsive Contrast Agentsmentioning

confidence: 99%

“…It is Reproduced with permission. [57] Copyright 2022, the authors, published by Elsevier GmbH. essential to monitor the treatment process, enabling the selection of appropriate timing and intensity for controlled treatment to achieve better treatment outcomes through individualized treatments.…”

Section: Self-monitoring During Tumor Therapymentioning

confidence: 99%

“…c) MTAI and d) thermoacoustic signal intensity result of EMT6 tumor-bearing mice after intravenous administration of MNPs over time. e) Specific MTAI and f) statistical results of deep-located breast tumor before and 6 hours after injection of MNPs solution.Reproduced with permission [57]. Copyright 2022, the authors, published by Elsevier GmbH.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Self‐Monitoring Theranostic Nanomaterials: Emerging Visual Agents for Real‐Time Monitoring of Tumor Treatment Processes

Su,

Zhao,

Ying

et al. 2023

Small Methods

View full text Add to dashboard Cite

Self‐monitoring in tumor therapy is a concept that allows for real‐time monitoring of the location and state of applied nanomaterials. This monitoring relies on dynamic signals, such as wave or magnetic signals, which vary in response to changes in the location and state of nanomaterials. Dynamic changes in nanomaterials can be monitored using dynamic signals, making it possible to determine and control the treatment process. Theranostic nanomaterials, which possess unique physical and chemical properties, have recently been explored as a viable option for self‐monitoring. With the help of self‐monitoring, theranostic nanomaterials can guide themselves to achieve region‐selective treatment with higher controllability and safety. In this review, self‐monitoring theranostic nanomaterials will be introduced in three parts according to their roles during therapy: tumor accumulation, tumor therapy, and metabolism. The limitations and future challenges of current self‐monitoring theranostic nanomaterials will also be discussed.

show abstract

Thermoacoustic concentration imaging of magnetic nanoparticles under single-pulse magnetic fields

Liu

2022

AIP Advances

View full text Add to dashboard Cite

Under a single-pulse magnetic field (SMF), we proposed a thermoacoustic (TA) concentration imaging method of magnetic nanoparticles (MNPs). This method derived the relationship between the concentration of MNPs and TA signals based on the mechanism of the TA effect. In the simulation, we ideally reconstructed the concentration map of the MNPs from the simulated TA signals. It proves the feasibility of the proposed method. In the experiment, a multi-channel acquisition system was built, and the MNP suspension with the iron concentration of 1 mg/ml was injected into two gaps of the phantom. Then, 128 TA signals were obtained by a multi-channel acquisition system. Finally, the imaging results faithfully reconstructed the cross-sectional image of the MNP area in the phantom. It is demonstrated that the TA concentration imaging of the MNPs under the SMF has the potential to achieve low-concentration MNP imaging in vivo, which provides a promising molecular imaging method for imaging MNP-labeled cancer tissues.

show abstract

Manganous-manganic oxide nanoparticle as an activatable microwave-induced thermoacoustic probe for deep-located tumor specific imaging in vivo

Cited by 7 publications

References 44 publications

Thermoacoustic Imaging-Guided Thermo-Chemotherapy for Hepatocellular Carcinoma Sensitized by a Microwave-Responsive Nitric Oxide Nanogenerator

Thermoacoustic Imaging-Guided Thermo-Chemotherapy for Hepatocellular Carcinoma Sensitized by a Microwave-Responsive Nitric Oxide Nanogenerator

Self‐Monitoring Theranostic Nanomaterials: Emerging Visual Agents for Real‐Time Monitoring of Tumor Treatment Processes

Thermoacoustic concentration imaging of magnetic nanoparticles under single-pulse magnetic fields

Contact Info

Product

Resources

About