Understanding the formation mechanism of gallium nitride (GaN) crystals in different crystal orientations to optimize the crystal quality and improve device performance is important to achieving high-performance devices. Despite significant advances in experimental techniques to study the microstructure and anisotropic differences during semiconductor crystal growth, it is still difficult to dynamically observe the microstructure evolution during GaN crystal growth at the atomic level. In this paper, the anisotropic differences in the induced growth of GaN crystals are investigated by means of molecular dynamics simulations. The results show that the crystal defects in each crystal orientation show a decreasing trend during induced growth. The generation and motion of dislocations in the GaN crystals are anisotropic. The microstructure evolution during the anisotropic growth of crystals and the mechanism of defect structure formation were investigated in detail by crystal-induced melt growth in three crystal orientations, and it was found that the crystals grown in the [1̅ 21̅ 0] crystal orientation possess optimal growth quality. These results show the growth mechanism of GaN in different crystal orientations and provide theoretical guidance for the preparation of highquality GaN.