Deep White Matter Hyperintensities, Decreased Serum Low-Density Lipoprotein, and Dilative Large Arteriopathy

Ichikawa, Hiroo; Mukai, Masanori; Ohno, Hideki; Shimizu, Yuki; Itaya, Kazuhiro; Kawamura, Mitsuru

doi:10.1016/j.jstrokecerebrovasdis.2010.07.002

Cited by 12 publications

(12 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lastly, we examined for interactions between several lipid profile components and apoE isoforms and it is possible that our findings of differential effects may have been due to chance. Nonetheless, our findings are in keeping with other studies that have shown either a paradoxical[10, 21, 22], or no, association[37] between plasma lipid profile components and subclinical cerebrovascular disease.…”

Section: Discussionsupporting

confidence: 93%

“…Two recent studies showed a an association between dyslipidemia and lower WMH volumes, one study being a community cohort referred for clinical MRI[22] and another an analysis of acute ischemic stroke patients[10]. The largest study to date has been the Cardiovascular Health Study (CHS), which demonstrated increased WMH volumes over time among participants with high HDL-C and low LDL-C[21].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Lipid Profile Components and Subclinical Cerebrovascular Disease in the Northern Manhattan Study

et al. 2014

View full text Add to dashboard Cite

Background: Subclinical cerebrovascular disease has been associated with multiple adverse events related to aging, including stroke and dementia. The modifiable risk factors for subclinical cerebrovascular disease beyond hypertension have not been well characterized. Our objective was to examine the association between baseline, and changes over time, in lipid profile components and subclinical cerebrovascular disease on magnetic resonance imaging (MRI). Methods: Fasting plasma lipids were collected on participants in the Northern Manhattan Study, a prospective cohort study examining risk factors for cardiovascular disease in a multiethnic elderly urban-dwelling population. A subsample of the cohort underwent brain MRI between 2003 and 2008 (a median of 6.2 years, range = 0-14, after enrollment), when repeat fasting lipids were obtained. We used lipid profile components at the time of initial enrollment (n = 1,256 with lipids available) as categorical variables, as well as change in clinical categories over the two measures (n = 1,029). The main outcome measures were (1) total white matter hyperintensity volume (WMHV) using linear regression and (2) silent brain infarcts (SBI) using logistic regression. Results: None of the plasma lipid profile components at the time of enrollment were associated with WMHV. The association between baseline lipids and WMHV was, however, modified by apolipoprotein E (apoE) status (χ² with 2 degrees of freedom, p = 0.03), such that among apoE4 carriers those with total cholesterol (TC) ≥200 mg/dl had a trend towards smaller WMHV than those with TC <200 mg/dl (difference in logWMHV -0.19, p = 0.07), while there was no difference among apoE3 carriers. When examining the association between WMHV and change in lipid profile components we noted an association with change in high-density lipoprotein cholesterol (HDL-C, >50 mg/dl for women, >40 mg/dl for men) and TC. A transition from low-risk HDL-C (>50 mg/dl for women, >40 mg/dl for men) at baseline to high-risk HDL-C at the time of MRI (vs. starting and remaining low risk) was associated with greater WMHV (difference in logWMHV 0.34, p value 0.03). We noted a similar association with transitioning to a TC ≥200 mg/dl at the time of MRI (difference in logWMHV 0.25, p value 0.006). There were no associations with baseline or change in lipid profile components with SBI. Conclusions: The association of plasma lipid profile components with greater WMHV may depend on apoE genotype and worsening HDL and TC risk levels over time.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Lipid Profile Components and Subclinical Cerebrovascular Disease in the Northern Manhattan Study

et al. 2014

View full text Add to dashboard Cite

show abstract

“…; Ichikawa et al. ), data in this study indicated that higher LDL‐C levels were associated with lower severity of WMLs. The mechanisms of the inverse correlation between LDL‐C and PVH are not fully understood, but cholesterol is thought to play important roles in neuron repair and remodeling in the central nervous system (Dietschy and Turley ).…”

Section: Discussionsupporting

confidence: 60%

Association of cerebral white matter lesions with cognitive function and mood in Japanese elderly people: a population‐based study

et al. 2015

View full text Add to dashboard Cite

BackgroundTo determine the relationships between regional white matter lesions (WMLs), lifestyle factors, and cognitive, motor function and mood.MethodsA comprehensive evaluation, including brain MRI, blood tests, the Unified Parkinson's Disease Rating Scale, the Mini Mental State Examination, and the Geriatric Depression Scale, was performed for people aged 65 years or older living in Ama-cho on October 1, 2009. Participants were classified by severity of periventricular hyperintensities (PVH) and deep white matter hyperintensities (DWMH) using the Fazekas score.ResultsOf 900 eligible participants, 688 (76.4%) were enrolled, including 303 men. Significant predictors of severe PVH were older age, lower low-density lipoprotein cholesterol (LDL-C) levels, elevated blood pressure (BP), cerebral infarction, and no current alcohol use. Significant predictors of severe DWMH were older age, lower 1,5-anhydroglucitol (1,5-AG) levels, elevated BP, cerebral infarction, and no current alcohol use. Higher cognitive function was associated with younger age, female sex, mild DWMH, more years of education, and higher high-density lipoprotein cholesterol levels. Depressive symptoms were associated with lower 1,5-AG levels, lower LDL-C levels, moderate to severe PVH, and no current alcohol use.ConclusionsWhite matter lesions in elderly people were related to hypertension and impaired glucose tolerance. The severity of WMLs was associated with cognitive function and mood.

show abstract

“…For example, people receiving treatment might also receive better health care than those who remain untreated. Others have reported associations linking higher continuous LDL levels with reduction in WMH and larger brain volumes in multiethnic US samples [49,50] and in an outpatient sample in Japan [51]. The mechanism underlying this somewhat paradoxical relationship is uncertain, but it might be related to the special role of cholesterol in the repair and metabolism of white matter [52,53].…”

Section: Discussionmentioning

confidence: 99%

Vascular Risk Factors and Findings on Brain MRI of Elderly Adult American Indians: The Strong Heart Study

et al. 2019

View full text Add to dashboard Cite

Background: Clinical stroke is prevalent in American Indians, but the risk factors for cerebrovascular pathology have not been well-studied in this population. The purpose of this study was to correlate abnormalities on brain magnetic resonance imaging (MRI) with clinical risk factors in a cohort of elderly American Indians. Methods: Brain MRI scans from 789 participants of the Strong Heart Study were analyzed for infarcts, hemorrhage, white matter disease, and measures of cerebral atrophy including ventricular and sulcal grade and total brain volume. Clinical risk factors included measures of hypertension, diabetes, and high levels of low-density lipoprotein (LDL) cholesterol. Regression models adjusted for potential confounders were used to estimate associations between risk factors and brain MRI outcomes. Results: Hypertension was associated with the presence of infarcts (p = 0.001), ventricle enlargement (p = 0.01), and increased white matter hyperintensity volume (p = 0.01). Diabetes was associated with increased prevalence of cerebral atrophy (p < 0.001), ventricular enlargement (p = 0.001), and sulcal widening (p = 0.001). High LDL was not significantly associated with any of the measured cranial imaging outcomes. Conclusions: This study found risk factors for cerebrovascular disease in American Indians similar to those seen in other populations and provides additional evidence for the important roles of hypertension and diabetes in promoting cerebral infarcts and brain atrophy, respectively.

show abstract

Deep White Matter Hyperintensities, Decreased Serum Low-Density Lipoprotein, and Dilative Large Arteriopathy

Cited by 12 publications

References 30 publications

Lipid Profile Components and Subclinical Cerebrovascular Disease in the Northern Manhattan Study

Lipid Profile Components and Subclinical Cerebrovascular Disease in the Northern Manhattan Study

Association of cerebral white matter lesions with cognitive function and mood in Japanese elderly people: a population‐based study

Vascular Risk Factors and Findings on Brain MRI of Elderly Adult American Indians: The Strong Heart Study

Contact Info

Product

Resources

About