Deep Venous Thrombosis

Olaf, Mark; Cooney, Robert

doi:10.1016/j.emc.2017.06.003

Cited by 93 publications

(77 citation statements)

References 90 publications

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“…There may be many causes to the low number of scans among the majority of GPs. First, an average GP can expect to see conditions such as DVT [25] or first trimester bleeding only a few times a year. Availability of the equipment is another aspect that may affect the use of POCUS.…”

Section: Discussionmentioning

confidence: 99%

Point-of-care ultrasound (POCUS) in Norwegian general practice

Myklestul

Skonnord

Brekke

2020

Scandinavian Journal of Primary Health Care

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Section: Discussionmentioning

confidence: 99%

Point-of-care ultrasound (POCUS) in Norwegian general practice

Myklestul

Skonnord

Brekke

2020

Scandinavian Journal of Primary Health Care

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“…Deep vein thrombosis (DVT) causes significant morbidity and mortality. 1 In addition to fatal pulmonary embolism, DVT results in postphlebitic syndrome up to 50% of patients. 2 Current treatments of DVT with anticoagulant, antiplatelet, and thrombolytic drugs have a risk of severe hemorrhage.…”

Section: Introductionmentioning

confidence: 99%

Aqueous Extract of Whitmania Pigra Whitman Alleviates Thrombus Burden Via Sirtuin 1/NF-κB Pathway

Yao

Liu

et al. 2020

Journal of Surgical Research

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“…Deep venous thrombosis (DVT) refers to the formation of a blood clot within a deep vein in contrast with venous thromboembolism, which includes superficial thrombophlebitis and pulmonary embolism [1]. DVT will lead to morbidity and mortality in several conditions [2].…”

Section: Introductionmentioning

confidence: 99%

Down-regulation of miR-361-5p promotes the viability, migration and tube formation of endothelial progenitor cells via targeting FGF1

et al. 2020

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Transplantion of bone marrow-derived endothelial progenitor cells (EPCs) may be a novel treatment for deep venous thrombosis (DVT). This study probed into the role of miR-361-5p in EPCs and DVT recanalization. EPCs were isolated from male SD rats and identified using flow cytometry. The viability, migration and tube formation of EPCs were examined using MTT assay, wound-healing assay and tube formation assay, respectively. Target gene and potential binding sites between miR-361-5p and FGF1 were predicted by starBase and confirmed by dual-luciferase reporter assay. Relative expressions of miR-361-5p and FGF1 were detected using quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot as needed. A DVT model in SD rats was established to investigate the role of EPC with miR-361-5p antagomir in DVT by hematoxylin-eosin staining. EPC was identified as 87.1% positive for CD31, 2.17% positive for CD133, 85.6% positive for vWF and 94.8% positive for VEGFR2. MiR-361-5p antagomir promoted proliferation, migration and tube formation of EPCs and upregulated FGF1 expression, thereby dissolving thrombus in the vein of DVT rats. FGF1 was the target of miR-361-5p, and overexpressed FGF1 reversed the effects of upregulating miR-361-5p on suppressing EPCs. Downregulation of miR-361-5p enhanced thrombus resolution in vivo and promoted EPC viability, migration and angiogenesis in vitro through targeting FGF1. Therefore, miR-361-5p may be a potential therapeutic target for DVT recanalization.

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Deep Venous Thrombosis

Cited by 93 publications

References 90 publications

Point-of-care ultrasound (POCUS) in Norwegian general practice

Point-of-care ultrasound (POCUS) in Norwegian general practice

Aqueous Extract of Whitmania Pigra Whitman Alleviates Thrombus Burden Via Sirtuin 1/NF-κB Pathway

Down-regulation of miR-361-5p promotes the viability, migration and tube formation of endothelial progenitor cells via targeting FGF1

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