Deep TMS for comorbid Major Depressive Disorder and Anxiety – A Brief Report of Patients in a Real-World Practice

Hovav, Sarit; Kinback, Kevin M.

doi:10.1016/j.brs.2014.07.012

Brain Stimulation

2014

DOI: 10.1016/j.brs.2014.07.012

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Deep TMS for comorbid Major Depressive Disorder and Anxiety – A Brief Report of Patients in a Real-World Practice

Sarit Hovav

Kevin M. Kinback

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2020

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“…Karan Narwal1,2 , William Hervey M.D3,4 . 1 CEO & Director of Research e THE TMS ADVANTAGE, Clearwater, FL; 2 Aureus University School of Medicine'18 & NYIT '09; 3 Chief Medical Officer, Advantage Mental Health, Clearwater, FL; 4 Associate Professor, USF Morsani College of Medicine, Tampa, FL (There was no funding for this study)…”

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Bipolar Depressed Patients Respond Better to rTMS Than Unipolar Depressed Patients

2020

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d-cycloserine (DCS), an NMDA receptor partial agonist vs. placebo on motor evoked potentials (MEPs) before and after 300 pulses (1.5 sec on/ 58.5 sec off) of 10 Hz rTMS over the left motor cortex at 80% motor threshold. Baseline MEP measures were taken 1 hour after drug administration to account for effects on baseline excitability, rTMS was then administered 2 hours after drug, and post-TMS measures were obtained every 15 minutes for 1 hour following rTMS. Results: Averaged normalized MEPs over the time course were higher when participants received DCS than placebo, with an overall increase in least squares means from 1.27 (placebo) to 1.55 (DCS), difference of 0.29, standard error 0.14 (F¼4.48, df¼62; p¼0.038). Baseline data (raw values) were not significantly different per student's two-tailed paired t-test, placebo 1.129 mV; DCS 0.956 mV; p¼0.173. Conclusions: Consistent with our hypothesis that 10 Hz rTMS may work through LTP, a modest, but significant, potentiating effect of d-cycloserine was observed on MEPs after 10 Hz rTMS. This pilot data highlights the need for larger mechanistic studies. Conflicts of Interests: None.

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Bipolar Depressed Patients Respond Better to rTMS Than Unipolar Depressed Patients

2020

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Deep TMS for comorbid Major Depressive Disorder and Anxiety – A Brief Report of Patients in a Real-World Practice

Cited by 1 publication

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Bipolar Depressed Patients Respond Better to rTMS Than Unipolar Depressed Patients

Bipolar Depressed Patients Respond Better to rTMS Than Unipolar Depressed Patients

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