Deep tissue contractility sensing with biointegrated microlasers

Abstract

Characterizing single cell contractility in the beating heart is strongly limited by light scattering and extreme tissue dynamics. Here, we use tissue-integrated microlasers to measure contractility in live zebrafish and living myocardial slices at a depth several times deeper than multiphoton microscopy-based techniques.

Motor-like microlasers functioning in biological fluids

“…[19][20][21][22][23][24][25] Recent studies have also incorporated microlasers with cells or tissues, aiming to reveal biological behaviours at the cellular level. [26][27][28][29][30] In spite of the progress that has been developed, [31][32][33][34] manipulation of microlasers under large dimensions with controllable and versatile functions remains a key challenge. Exploring a versatile way for driving and controlling coherent light sources in liquid environment holds great potential in photostimulation and photoactivable reactions.…”