Deep tiny flow voids along middle cerebral artery atherosclerotic occlusions: A high-resolution MR imaging study

New vessels formation in young strokes with isolated steno‐occlusive MCA

“…Xu et al. had found an unique new vessels formation phenomenon named deep tiny flow voids (DTFV) on MRI, which was defined as vascular formation along the steno‐occlusive MCA and distinct from moyamoya collaterals (Xu, Li, Gao, Hou, & Sun, ; Xu et al., ).Their studies indicated that these new vessels were in response to chronic cerebral ischemia.…”

Non-moyamoya vessel network formation along steno-occlusive middle cerebral artery

“…In 2014, a novel finding of "deep tiny flow voids" (DTFV), defined as 3 or more flow voids along the middle cerebral artery (MCA) on HRMRI, was reported. 13 DTFV were commonly observed along MCA occlusions but never seen along normal MCAs, supporting that they are pathologic collaterals. The aim of the present study was to further examine the prevalence and clinical relevance of DTFV in patients with stenotic or occlusive MCA disease.…”

“…We retrospectively reviewed our institutional, prospectively collected HRMRI database (from January 2007 to March 2015). 8,9,[12][13][14] All patients had undergone routine MRI and magnetic resonance angiography (MRA) examinations for a clinical diagnosis. Patients with symptomatic MCA stenoocclusive disease were recruited if there was an ischemic stroke in the distribution of the affected MCA within 3 months of stroke onset.…”

“…Patients with symptomatic MCA stenoocclusive disease were recruited if there was an ischemic stroke in the distribution of the affected MCA within 3 months of stroke onset. 11,13 Patients with asymptomatic MCA steno-occlusive disease were included if there was no history of cerebrovascular events or if an ischemic event occurred in a vascular territory outside the affected MCA. 9 Patients with moyamoya disease were enrolled if they had bilateral stenosis and/or occlusion of the intracranial internal carotid artery and its proximal branches, with development of a collateral network.…”

“…The detailed HRMRI protocol was described elsewhere. 8,13 Briefly, the cross-section imaging was obtained with a display resolution of 0.25 3 0.25 3 2 mm, and perpendicular to the M1 segment of the MCA.…”