Deep Regression Segmentation for Cardiac Bi-Ventricle MR Images

Du, Xiujuan; Zhang, Weiwei; Zhang, Heye; Chen, Jun; Zhang, Yanping; Warrington, James; Brahm, Gary; Li, Shuo

doi:10.1109/access.2017.2789179

Cited by 40 publications

(23 citation statements)

References 28 publications

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“…On this basis, a motion grid energy model is designed to extract and track the intersection of marker lines in cardiac motion image sequences. [ 16 , 17 ] The method can effectively segment the left ventricle, and the measurement of the image parameters has good reproducibility, and can overcome the noise in the cardiac magnetic resonance image and the influence of the surrounding tissue of the heart. It has good accuracy.…”

Section: Discussionmentioning

confidence: 99%

STROBE—A preliminary investigation of IVIM-DWI in cardiac imaging

Xiang¹,

Zhang

Yang³

et al. 2018

Medicine

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This study aims to explore the possibility to apply intravoxel incoherent motion-magnetic resonance imaging (IVIM-MRI) in cardiac imaging.Multi-b-value diffusion-weighted imaging (DWI) sequence scanning was performed on 12 healthy volunteers. A double exponential model was adopted, and the b-value sequence was 0, 20, 60, 80, 120, 200, and 600 second/mm2. The D-value, D∗-value, and f-value of the anterior posterior and lateral walls of the ventricular septum were respectively measured on the short axis section of the heart, the parameters of the myocardium in different blood supply areas in each segment were recorded, and the measured data of these different segments were compared using analysis of variance.Among these 12 healthy volunteers, the D-value, D∗-value, and f-value of these 72 segments were not exactly equal, the D-values of the myocardium in the 5th and 11th segment were lower than those in the 2nd, 3rd, 8th, and 9th segments, and the pairwise differences were statistically significant (P < .001). Furthermore, the difference in D-value between the 5th and 11th segments was not statistically significant (P = 1.000). The D∗-value and f-value of the myocardium in the 5th and 11th segment were higher than those in the 2nd, 3rd, 8th, and 9th segments, and the pairwise differences were statistically significant (P < .001). Furthermore, the differences in D∗-value and f-value between the 5th and 11th segments was not statistically significant (P = .214, .787).The intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) technique can quantitatively reflect the diffusion and blood perfusion status of the myocardium.

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Section: Discussionmentioning

confidence: 99%

STROBE—A preliminary investigation of IVIM-DWI in cardiac imaging

Xiang¹,

Zhang

Yang³

et al. 2018

Medicine

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“…It was establish a framework to produce flow information and set of reference data to compare with unusual flow patterns due to cardiac abnormalities. In addition, Du propose a regression segmentation framework (Bi-DBN) to automatically segment bi-ventricle by establishing a boundary regression model that implicates the nonlinear mapping relationship between cardiac MR images and desired object boundaries [ 46 ]. Zhang propose meshfree particle computational method for cardiac image analysis with the energy minimization formulations to solve the fundamental problem about the optimal mathematical description in cardiac image analysis on a digital computer [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Hemodynamic effects of perfusion level of peripheral ECMO on cardiovascular system

Zhang

Gao

et al. 2018

BioMed Eng OnLine

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BackgroundPeripheral ECMO is an effective cardiopulmonary support in clinical. The perfusion level could directly influence the performances and complications. However, there are few studies on the effects of the perfusion level on hemodynamics of peripheral ECMO.MethodsThe geometric model of cardiovascular system with peripheral ECMO was established. The blood assist index was used to classify the perfusion level of the ECMO. The flow pattern from the aorta to the femoral artery and their branches, blood flow rate from aorta to brain and limbs, flow interface, harmonic index of blood flow, wall shear stress and oscillatory shear index were chosen to evaluate the hemodynamic effects of peripheral ECMO.ResultsThe results demonstrated that the flow rate of aorta outlets increased and perfusion condition had been improved. And the average flow to the upper limbs and brain has a positive correlation with BAI (r = 0.037, p < 0.05), while there is a negative correlation with lower limbs (r = − 0.054, p < 0.05). The HI has negative correlation with BAI (p < 0.05, r < 0). The blood interface is further from the heart with the BAI decrease. And the average WSS has negative correlation with BAI (p < 0.05, r = − 0.983) at the bifurcation of femoral aorta and has positive correlation with BAI (p < 0.05, r = 0.99) at the inner aorta. The OSI under different BAI is higher (reaching 0.4) at the inner wall of the aortic arch, the descending aorta and the femoral access.ConclusionsThe pathogenesis of peripheral ECMO with different perfusion levels varies; its further research will be thorough and extensive.

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“…To achieve our goal, we adapted an image-based electromechanical model of the human ventricular heart from Johns Hopkins University [ 16 ]. Human ventricular geometries were generated using the methodology described by Gurev et al [ 17 – 20 ]. The three-dimensional human ventricular finite-element model used in this study consists of a lumped-parameter model of the physiological circulatory system [ 20 , 21 ].…”

Section: Methodsmentioning

confidence: 99%

“…Human ventricular geometries were generated using the methodology described by Gurev et al [ 17 – 20 ]. The three-dimensional human ventricular finite-element model used in this study consists of a lumped-parameter model of the physiological circulatory system [ 20 , 21 ]. Our ventricular model for the electrophysiological simulation consisted of 214,319 tetrahedral finite elements.…”

Section: Methodsmentioning

confidence: 99%

The effect of myocardial action potential duration on cardiac pumping efficacy: a computational study

Jeong

Lim

2018

BioMed Eng OnLine

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Background and aimsAlthough studies on the relation between arrhythmias and the action potential duration (APD) have been carried out, most of them are based only on electrophysiological factors of the heart and lack experiments that consider cardiac mechanical and electromechanical characteristics. Therefore, we conducted this study to clarify the relevance of the shortening of APD of a cell in relation to the mechanical contraction activity of the heart and the associated risk of arrhythmia.MethodsThe human ventricular model used in this study has two dynamic characteristics: electrophysiological conduction and mechanical contraction. The model simulating electrophysiological characteristics was consisted of lumped parameter circuit that can mimic the phenomenon of ion exchange through the cell membrane of myocyte and consisted of 214,319 tetrahedral finite elements. In contrast, the model simulating mechanical contraction characteristics was constructed to mimic cardiac contraction by means of the crossbridge of a myofilament and consisted of 14,720 hermite-based finite elements to represent a natural 3D curve of the cardiac surface. First, we performed a single cell simulation and the electrophysiological simulation according to the change of the APD by changing the electrical conductivity of the IKs channel. Thus, we confirmed the correlation between APD and intracellular Ca2+ concentration. Then, we compared mechanical response through mechanical simulation using Ca2+ data from electrical simulation.ResultsThe APD and the sum of the intracellular Ca2+ concentrations showed a positive correlation. The shortened APD reduced the conduction wavelength of ventricular cells by shortening the plateau and early repolarization in myocardial cells. The decrease in APD reduced ventricular pumping efficiency by more than 60% as compared with the normal group (normal conditions). This change is caused by the decline of ventricular output owing to reduced ATP consumption during the crossbridge of myofilaments and decreased tension.ConclusionThe shortening of APD owing to increased electrical conductivity of a protein channel on myocardial cells likely decreases the wavelength and the pumping efficiency of the ventricles. Additionally, it may increase tissue sensitivity to ventricular fibrillation, including reentry, and cause symptoms such as dyspnea and dizziness.

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Deep Regression Segmentation for Cardiac Bi-Ventricle MR Images

Cited by 40 publications

References 28 publications

STROBE—A preliminary investigation of IVIM-DWI in cardiac imaging

STROBE—A preliminary investigation of IVIM-DWI in cardiac imaging

Hemodynamic effects of perfusion level of peripheral ECMO on cardiovascular system

The effect of myocardial action potential duration on cardiac pumping efficacy: a computational study

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