STROBE—A preliminary investigation of IVIM-DWI in cardiac imaging

Abstract

This study aims to explore the possibility to apply intravoxel incoherent motion-magnetic resonance imaging (IVIM-MRI) in cardiac imaging.Multi-b-value diffusion-weighted imaging (DWI) sequence scanning was performed on 12 healthy volunteers. A double exponential model was adopted, and the b-value sequence was 0, 20, 60, 80, 120, 200, and 600 second/mm2. The D-value, D∗-value, and f-value of the anterior posterior and lateral walls of the ventricular septum were respectively measured on the short axis section of the heart, the parameters of the myocardium in different blood supply areas in each segment were recorded, and the measured data of these different segments were compared using analysis of variance.Among these 12 healthy volunteers, the D-value, D∗-value, and f-value of these 72 segments were not exactly equal, the D-values of the myocardium in the 5th and 11th segment were lower than those in the 2nd, 3rd, 8th, and 9th segments, and the pairwise differences were statistically significant (P < .001). Furthermore, the difference in D-value between the 5th and 11th segments was not statistically significant (P = 1.000). The D∗-value and f-value of the myocardium in the 5th and 11th segment were higher than those in the 2nd, 3rd, 8th, and 9th segments, and the pairwise differences were statistically significant (P < .001). Furthermore, the differences in D∗-value and f-value between the 5th and 11th segments was not statistically significant (P = .214, .787).The intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) technique can quantitatively reflect the diffusion and blood perfusion status of the myocardium.

Intravoxel Incoherent Motion Magnetic Resonance Imaging with Integrated Slice-specific Shimming for old myocardial infarction: A Pilot Study

“…Nevertheless, the complexity of cardiac anatomy and physiological movement affects the image quality in the DWI, which in turn affects the accuracy of IVIM-DWI parameters. In this experiment, iShim sequence was used for the IVIM-DWI imaging, which is an improvement in the traditional EPI sequence compared with the traditional DWI 7 . In comparison with the conventional single-shot EPI sequencing, the advantages of the iShim sequencing lie in the facts that: (1) corresponding b-values can be selected reasonably according to the requirements of the experiment, especially when the b-values are small, so as to improve the fitting accuracy of the D* value 8 ; (2) it can reduce image distortion; the iShim sequence scans a B0-Map before scanning each slice, and the signal changes of the B0-Map are used to correct the distortion of EPI, thereby contributing to the improvement in the distortion caused by the heterogeneity of the main magnetic field; (3) it can exert a better fat-suppression effect; specifically, the sequence can achieve a more thorough suppression of fatty tissue signals, by improving the accuracy of fat-selective pulses and using a slice-selection gradient-reversal fat-suppression technique; (4) it optimises the image acquisition mode, allows higher acquisition times, increases the signal-to-noise ratio and further improves the accuracy of parameter fitting.…”

“…IVIM can reflect the diffusion and perfusion of living tissues through multi-parameter measurements. Therefore, IVIM may play an important supplementary role to conventional CMR in patients with heart disease who cannot tolerate drug therapy 7,8 . We hypothesized that the IVIM-DWI had a good value in diagnosing old myocardial infarction and myocardial fibrosis.…”

The Value of the Cardiac Magnetic Resonance Intravoxel Incoherent Motion Technique in Evaluating Microcirculatory Dysfunction in Hypertrophic Cardiomyopathy

“…Mou et al [ 14 ] found that the left ventricular myocardium of patients with HCM was significantly lower than the D ∗ myocardium of healthy people, indicating that the myocardium of HCM patients had low perfusion injury, which suggested that IVIM imaging was helpful for the prediction and monitoring of myocardial microcirculation. Xiang et al [ 15 ] confirmed different myocardial perfusion parameters in different coronary artery blood supply areas via IVIM imaging. Finally, An et al [ 16 ] showed that the D ∗ and f values decreased significantly in the myocardial infarction area, while the D value showed a downward trend after PCI.…”

Myocardium microcirculation study in a healthy Chinese population using 3.0-T cardiac magnetic resonance intravoxel incoherent motion imaging

“…(11) and Xiang et al. (15) included 12 healthy volunteers; Moulin et al. (16) included 10 healthy volunteers; and Rapacchiet et al.…”