Deep morphea in a child after pneumococcal vaccination

Morphea in two patients after being infected to and being vaccinated against SARS-CoV-2 infection

“…On the other hand, we can name Diphtheria-Tetanus-Pertussis (DTP), hepatitis B, BCG, and pneumococcal vaccines among the ones reported to be associated with morphea (27)(28)(29)(30)(31)(32). However, most of the aforementioned conditions occurred locally and in the vaccine injection sites, rather than appearing in generalized types (28,30). Up to the present time, no case of morphea has been reported following SARS-CoV-2 vaccination.…”

Erythema multiforme following pneumococcal vaccination

“…Systemic side effects of PCV 13 include chills, fever, headache, vomiting, fatigue, arthralgia, myalgias, decreased appetite, and diarrhea (4). Furthermore, vaccination with PCV13 is reportedly associated with the following adverse cutaneous reactions: topical reactions at or near the injection sites (redness, edema, pain, abscess, cellulitis, itching granuloma, keratoacanthoma, and lichenoid dermatitis) (4), Sweet's syndrome (5), and deep morphea (6).…”

Current Take on Systemic Sclerosis Patients’ Vaccination Recommendations

“…The etiology of systemic sclerosis is closely correlated with a genetic profile; thus, relatives of patients with systemic sclerosis are at increased risk of getting the disease because they also share common eventual environmental triggers [162]. In addition, cases of autoimmune diseases triggered by vaccinations are reported [163][164][165][166][167][168][169]. Thus, vaccination could be a concern for family members of patients with systemic sclerosis.…”