Deep eutectic solvents are not only effective extractants

Shishov, Andrey; Pochivalov, Aleksei; Nugbienyo, Lawrence; Andruch, Vasiľ; Bulatov, Andrey

doi:10.1016/j.trac.2020.115956

Cited by 158 publications

(54 citation statements)

References 123 publications

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“…Deep eutectic solvents are an appropriate and green alternative to ionic liquids, which consist of two or more components, including a hydrogen bond acceptor (HBA) and a hydrogen bond donor (HBD). The DESs have several unique properties including low-toxicity compounds and fast and simple synthesis, and did not require purification in comparison with ionic liquids (Shishov et al, 2020). In addition, the development of the hydrophobic DESs has a wide range of applications in the microextraction methods (Kanberoglu et al, 2019;Shishov et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Nanofluid of magnetic‐activated charcoal and hydrophobic deep eutectic solvent: Application in dispersive magnetic solid‐phase extraction for the determination and preconcentration of warfarin in biological samples by high‐performance liquid chromatography

Nia

Hadjmohammadi

2021

Biomedical Chromatography

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In this study, for the first time, nanofluid of magnetic-activated charcoal and hydrophobic deep eutectic solvent (AC@Fe 3 O 4 -DES) based dispersive magnetic solid-phase extraction was successfully applied for the determination and preconcentration of warfarin in plasma and urine samples. The hydrophobic DES was prepared by mixing tetramethylammonium chloride (as hydrogen bond acceptor) and thymol (as hydrogen bond donor) and acted simultaneously as both carrier and stabilizer for magnetic nanoparticles. In this method, the nanofluid as a new extraction solvent was rapidly injected into the aqueous sample, which led to improvement of the mass transfer of the analytes into the sorbent and reduction of the extraction time. In the screening step, the fractional factorial design was applied for selecting some important parameters which significantly affected the extraction procedure.The effective parameters were then optimized by Box-Behnken design. Under the optimal conditions, the limits of detection were in the range of 0.3-1.6 ng/ml. A good linear range was observed in the range of 1.0-500.0 ng/ml for water and 5.0-500.0 ng/ml for urine and plasma. The intra-and inter-day relative standard deviations were 2.7-3.2 and 1.9-4.5% for five replications, respectively. Based on the results, the proposed method was successfully applied for the determination of warfarin in biological samples, using high-performance liquid chromatography.

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Section: Introductionmentioning

confidence: 99%

Nanofluid of magnetic‐activated charcoal and hydrophobic deep eutectic solvent: Application in dispersive magnetic solid‐phase extraction for the determination and preconcentration of warfarin in biological samples by high‐performance liquid chromatography

Nia

Hadjmohammadi

2021

Biomedical Chromatography

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“…However, these problems can be solved in two way, i.e. by adding water to the NADES component and by increasing the temperature [35].…”

Section: Methanol and Watermentioning

confidence: 99%

“…Besides selection of suitable NADES to increase the solubility of the target compound in the extraction process, it is also necessary to consider the extraction conditions, including the extraction method. Several methods based on heating, ultrasonic energy, and microwave radiation were proposed to enhance the mass-transfer of target molecules from the solid sample phase to the DES phase and minimize equilibrium time [35]. Wang et al, 2017 conducted a study to choose an appropriate DES for the effective extraction of chlorogenic acid from blueberry leaves.…”

Section: Methanol and Watermentioning

confidence: 99%

Natural Deep Eutectic Solvents (NADES): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development

Lusiana

Ramadon

Jantan

et al. 2021

Plants

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Natural products from plants were extracted and widely studied for their activities against many disease conditions. The selection of the extracting solvent is crucial to develop selective and effective methods for the extraction and isolation of target compounds in the plant matrices. Pharmacological properties of plant extracts and their bioactive principles are related to their excellent solubility, stability, and bioavailability when administered by different routes. This review aims to critically analyze natural deep eutectic solvents (NADES) as green solvents in their application to improve the extraction performance of plant metabolites in terms of their extractability besides the stability, bioactivity, solubility, and bioavailability. Herein, the opportunities for NADES to be used in pharmaceutical formulations development including plant metabolites-based nutraceuticals are discussed.

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“…Replacing or reducing hazardous compounds consumption has attracted more attentions among analytical scientists. As a result, the use of new generation of solvents like deep eutectic solvents (DESs) represents a significant benefit in the field of GAC by their application in microextraction methods [19][20][21][22][23][24]. DESs are the solvents which are mostly prepared by mixing quaternary alkyl ammonium salts as hydrogen bond acceptors (HBAs) with amines, alcohols, and carboxylic acids as hydrogen bond donors (HBDs).…”

Section: Introductionmentioning

confidence: 99%

Development of a surfactant‐assisted dispersive solid phase extraction using deep eutectic solvent to extract four tetracycline antibiotics residues in milk samples

Nemati

Farajzadeh

Mogaddam

2021

J of Separation Science

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In this study, a new floating dispersive solid phase extraction method based on deep eutectic solvents has been developed in a home-made extraction device for the extraction of four tetracycline antibiotics from milk samples. In this approach, the sorbent (activated carbon) was dispersed in whole parts of solution with the aid of air stream and floated on top of the solution with the aid of the surfactant (lauryl betaine) and air bubbles. After collection of the sorbent, the adsorbed analytes were eluted with tetrabutyl ammonium chloride-propionic acid deep eutectic solvent under sonication. In this method, there was no need of organic dispersive and extraction solvents and the used sorbent was collected on top of the solution and collected without centrifugation. The validation parameters showed that low limits of detection (0.1-0.3 μg/kg) and quantification (0.6-1.0 μg/kg), acceptable enrichment factors (52-60), efficient extraction recoveries (80-91%), and satisfactory relative standard deviations (≤9.8%) were obtained. Eventually, the method was successfully applied on different milk samples and tetracycline was determined in them.

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Deep eutectic solvents are not only effective extractants

Cited by 158 publications

References 123 publications

Nanofluid of magnetic‐activated charcoal and hydrophobic deep eutectic solvent: Application in dispersive magnetic solid‐phase extraction for the determination and preconcentration of warfarin in biological samples by high‐performance liquid chromatography

Nanofluid of magnetic‐activated charcoal and hydrophobic deep eutectic solvent: Application in dispersive magnetic solid‐phase extraction for the determination and preconcentration of warfarin in biological samples by high‐performance liquid chromatography

Natural Deep Eutectic Solvents (NADES): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development

Development of a surfactant‐assisted dispersive solid phase extraction using deep eutectic solvent to extract four tetracycline antibiotics residues in milk samples

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