Deep brain stimulation of the subthalamic nucleus and the temporal discounting of primary and secondary rewards

Aiello, Marilena; Terenzi, Damiano; Furlanis, Giovanni; Catalan, Mauro; Manganotti, Paolo; Eleopra, Roberto; Belgrado, Enrico; Rumiati, Raffaella I.

doi:10.1007/s00415-019-09240-0

Cited by 9 publications

(9 citation statements)

References 33 publications

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“…Previous studies have shown the crucial role of the STN in inhibitory control processes, as a key component of the basal ganglia-thalamocortical circuit involved in motor and cognitive control (23–25,27). Also, the STN encodes both drug and natural reward values (16,33,67,68). Thus, our findings suggest that the presence of drug cue stimuli during an inhibitory task such as the SST can activate the STN, leading to increased inhibitory control, since STN inhibition reduces it (26,27,65).…”

Section: Discussionmentioning

confidence: 99%

“…These cortico-STN hyperdirect pathways facilitate the suppression of the ongoing motor response (28)(29)(30). Studies employing the SST in individuals with Parkinson's disease (PD) who received STN DBS have further provided causal evidence for the involvement of the STN in successful inhibitory control (31)(32)(33). The SST has found application in addiction research, as the ability to resist drug seeking and consumption rely heavily on voluntary, deliberate inhibition (34).…”

Section: Introductionmentioning

confidence: 99%

“…These cortico-STN hyperdirect pathways facilitate the suppression of the ongoing motor response (28–30). Studies employing the SST in individuals with Parkinson’s disease (PD) who received STN DBS have further provided causal evidence for the involvement of the STN in successful inhibitory control (31–33).…”

Section: Introductionmentioning

confidence: 99%

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Social Context and Drug Cues Modulate Inhibitory Control in Cocaine Addiction: involvement of the STN evidenced through Functional Magnetic Resonance Imaging

Terenzi,

Simon,

Gachomba

et al. 2023

Preprint

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BackgroundAddictions often develop in a social context, although the influence of social factors did not receive much attention in the neuroscience of addiction. Recent animal studies suggest that peer presence can reduce cocaine intake, an influence potentially mediated, among others, by the subthalamic nucleus (STN). However, there is to date no such neurobiological study in humans.MethodsThis study investigated the impact of social context and drug cues on brain correlates of inhibitory control in individuals with and without cocaine use disorder (CUD) using functional Magnetic Resonance Imaging (fMRI). Seventeen CUD participants and 17 healthy controls (HC) performed a novel fMRI Stop-Signal task in the presence and absence of an observer while being exposed to cocaine-related and neutral pictures as cues.ResultsThe results showed that CUD participants, while slower at stopping with neutral cues, recovered control level stopping abilities with cocaine cues, while HC did not show any difference. Neuroimaging revealed the involvement of frontal cortical regions and of the subthalamic nucleus (STN) in inhibitory control, which was modulated by both social context and drug cues in CUD participants but not in HC.ConclusionsThese findings highlight the impact of social context and drug cues on inhibitory control in CUD and suggest potential targets for intervention such as the STN, also emphasizing the importance of considering the social context in addiction research and treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Social Context and Drug Cues Modulate Inhibitory Control in Cocaine Addiction: involvement of the STN evidenced through Functional Magnetic Resonance Imaging

Terenzi,

Simon,

Gachomba

et al. 2023

Preprint

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“…Clinically, PD is defined as a progressive movement disorder, including bradykinesia, rigidity, and rest tremor [ 7 , 8 ]. Furthermore, PD is often characterized by different nonmotor symptoms affecting sensory perception, cognition, mood, motivation, autonomic functions, and sleep, among others [ 9 , 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Nutrition and Gut–Brain Pathways Impacting the Onset of Parkinson’s Disease

2022

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An emerging body of literature suggests that long-term gut inflammation may be a silent driver of Parkinson’s disease (PD) pathogenesis. Importantly, specific nutritive patterns might improve gut health for PD risk reduction. Here, we review the current literature on the nutritive patterns and inflammatory markers as a predictor for early detection of PD. This knowledge might be used to foster the detection of early nutritive patterns and preclinical biomarkers to potentially alter PD development and progression.

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“…Dysfunctions of STN circuits even produced perseverative actions with a reduced ability to switch between behaviors (Baker and Ragozzino, 2014; Baunez et al, 2007), making this brain region a good candidate for regulating self-control and delayed gratification. Until now, however, existing evidence is mixed on whether the STN is causally involved in temporal discounting (Aiello et al, 2019; Evens et al, 2015; Seinstra et al, 2016; Seymour et al, 2016; Uslaner and Robinson, 2006; Voon et al, 2017; Winstanley et al, 2005), and no previous study has investigated how STN neurons process value information across delays.…”

Section: Introductionmentioning

confidence: 99%

Neural dynamics underlying self-control in the primate subthalamic nucleus

Pasquereau

Turner²

2022

Preprint

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The subthalamic nucleus (STN) is hypothesized to play a central role in neural processes that regulate self-control. Still uncertain, however, is how that brain structure participates in the dynamically evolving representation of value that underlies the ability to delay gratification and wait patiently for a gain. To address that gap in knowledge, we studied the spiking activity of neurons in the STN of monkeys during a task in which animals were required to remain motionless for varying periods of time in order to obtain food reward. At the single-neuron and population levels, we found a cost-benefit integration between the desirability of the expected reward and the imposed delay to reward delivery, with STN signals that dynamically combined both attributes of the reward to form a single integrated estimate of value. This neural representation of subjective value evolved dynamically across the waiting period that intervened between instruction cue and reward delivery. Moreover, this representation was gradually distributed along the antero-posterior axis of the STN such that the most posterior-placed neurons represented the temporal discounting of value most strongly. These findings highlight the selective involvement of the posterior STN in a dynamic internal process that dynamically estimates the ongoing cost-benefit balance of the current context. Such a process is essential for self-control, promoting goal pursuit and the willingness to bear the costs of time delays.

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Deep brain stimulation of the subthalamic nucleus and the temporal discounting of primary and secondary rewards

Cited by 9 publications

References 33 publications

Social Context and Drug Cues Modulate Inhibitory Control in Cocaine Addiction: involvement of the STN evidenced through Functional Magnetic Resonance Imaging

Social Context and Drug Cues Modulate Inhibitory Control in Cocaine Addiction: involvement of the STN evidenced through Functional Magnetic Resonance Imaging

Nutrition and Gut–Brain Pathways Impacting the Onset of Parkinson’s Disease

Neural dynamics underlying self-control in the primate subthalamic nucleus

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