Deep brain stimulation of the inferior colliculus: A possible animal model to study paradoxical kinesia observed in some parkinsonian patients?

Melo-Thomas, Liana; Thomas, Uwe

doi:10.1016/j.bbr.2014.10.035

Cited by 23 publications

(33 citation statements)

References 44 publications

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“…2500 Hz stimulation of the IC effectively interferes with haloperidol-induced catalepsy, the effect is achieved by inducing a defence reaction, i.e. escape behaviour 15 , and therefore associated with clear aversive side effects. Moreover, the stimulation frequency is far outside the clinically effective range commonly used in the treatment of PD 3 , 17 – 19 .…”

Section: Resultsmentioning

confidence: 99%

“…To this aim, we implanted a stimulation electrode unilaterally into the central nucleus of the IC (Fig. 1a ) and first assessed each rat’s escape threshold individually during 2500 Hz stimulation of the IC using our standard protocol 15 . These thresholds, which verify electrode placement within the IC, were determined by successively increasing the current intensity in 20–50 μA steps until reaching the minimal current intensity producing escape behaviour, i.e.…”

Section: Resultsmentioning

confidence: 99%

“…Finally, the IC is considered as part of the brain defence system since electrical stimulation of this structure induces aversive behaviour in a graded manner 12 – 14 . High-frequency 2500 Hz electrical stimulation of the IC at specific current thresholds elicits escape behaviour 12 , 13 and we recently showed that such stimulation at these thresholds also induces vigorous escape responses in rats treated with haloperidol, thereby releasing the cataleptic state 15 . Such an effect is reminiscent of a clinical phenomenon known as paradoxical kinesia, i.e.…”

Section: Introductionmentioning

confidence: 91%

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Haloperidol–induced catalepsy is ameliorated by deep brain stimulation of the inferior colliculus

Engelhardt

Marchetta

Schwarting

et al. 2018

Sci Rep

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Deep brain stimulation (DBS) has evolved as a promising alternative treatment for Parkinson’s disease (PD), but the underlying mechanisms remain poorly understood. Moreover, conventional DBS protocols targeted at basal ganglia sites can turn out completely ineffective for some PD patients, warranting the search for alternative targets. The inferior colliculus (IC) is a midbrain auditory relay station involved in sensorimotor processes. High-frequency 2500 Hz electrical stimulation of the IC elicits escape behaviour and interferes with haloperidol-induced catalepsy in rats, a state reminiscent of Parkinsonian akinesia, but clinical implication is limited since the protocol is aversive. However, typical DBS stimulation frequencies range between 20–180 Hz. We therefore tested the effects of a low-frequency 30 Hz-DBS protocol on haloperidol-induced catalepsy and aversive behaviour in rats. We show that low-frequency 30 Hz-DBS targeted at the IC strongly ameliorates haloperidol-induced catalepsy without any evidence of stimulation-induced escape behaviour. Furthermore, 30 Hz-DBS of the IC produced no place avoidance in a place conditioning paradigm and induced no anxiety-related behaviour on the elevated plus maze, indicating that the protocol has no aversive or anxiogenic side effects. Our findings provide first evidence that the IC can serve as an alternative, non-conventional DBS target.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

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Haloperidol–induced catalepsy is ameliorated by deep brain stimulation of the inferior colliculus

Engelhardt

Marchetta

Schwarting

et al. 2018

Sci Rep

Self Cite

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“…Induction of tinnitus by salicylate in rats is reported to depict certain similarities to that of humans especially with respect to GABAergic neurotransmission . Moreover, IC plays a pivotal role in the normal processing of the acoustic message from the cochlear nucleus , making it critical in extracting relevant information on complex acoustic processing, including signal detection in noise, complex temporal coding, and sound localization. IC forms the prime candidate to be investigated in processing tinnitus‐related signals .…”

Section: Figurementioning

confidence: 96%

Observation of Lidocaine‐suppressed Decrease of Magnesium in Salicylate‐induced Tinnitus with an Online Electrochemical System

Liu

et al. 2018

Electroanalysis

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Tinnitus, characterized by an auditory perception in the absence of actual sound, is one of the most common encountered difficulties to manage otological problems, in which, lidocaine has been shown to provide temporary relief from subjective tinnitus. However, the pathophysiological mechanism of lidocaine treatment remains to be understood. The study demonstrates the first observation on that lidocaine well suppresses the decrease in the level magnesium (Mg2+) in inferior colliculus (IC) of guinea pigs following salicylate‐induced tinnitus with an online electrochemical system (OECS) for continuously monitoring of microdialysate of Mg2+. The OECS was established by efficiently coupling a selective electrochemical detector with in vivo microdialysis to monitor Mg2+ in the microdialysate continuously sampled from animal brain. The selective detection of Mg2+ over other coexisting neurochemicals was successfully achieved through a mechanism with divalent metal cations (e. g., Mg2+, Ca2+) enhanced catalytic current of organic dyes (i. e., polymerized film of toluidine blue O, p‐TBO) toward the oxidation of nicotinamide adenine dinucleotide (NADH) and with ethyleneglcol‐bis (2‐aminoethylether) tetraacetic acid (EGTA) as selective masking agents for Ca2+. Tinnitus was induced by intraperitoneal injection of sodium salicylate (350 mg/kg body weight). For the lidocaine group, using the microdialysis probe, 1 % lidocaine was perfused into IC of guinea pigs at 2 μL/min for 20 min. With the OECS, we found that the perfusion of lidocaine could recover the decrease of the Mg2+ level caused by salicylate‐induced tinnitus. The basal level of microdialysate Mg2+ in IC of guinea pigs was previously determined to be 1.29±0.44 mM, which was decreased significantly following salicylate‐induced tinnitus. The lidocaine perfusion significantly recovers the Mg2+ level by 37.7±14.8 %. This observation suggests that Mg2+ plays an important role in the pathological mechanism of tinnitus.

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“…Подопытные животные плавали и карабкались по стенкам коробки. L. Melo-Thomas и U. Thomas [63] вы-полнили стереотаксическую стимуляцию области нижних бугорков головного мозга крыс после предварительно вы-званной каталепсии за счет инъекций галоперидола. Ав-торы отметили значительное снижение каталепсии в ре-жиме стимуляции.…”

Section: экспериментальные моделиunclassified

Paradoxical kinesia in Parkinson’s disease: theories and practical application

Rotaru²

2016

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Deep brain stimulation of the inferior colliculus: A possible animal model to study paradoxical kinesia observed in some parkinsonian patients?

Cited by 23 publications

References 44 publications

Haloperidol–induced catalepsy is ameliorated by deep brain stimulation of the inferior colliculus

Haloperidol–induced catalepsy is ameliorated by deep brain stimulation of the inferior colliculus

Observation of Lidocaine‐suppressed Decrease of Magnesium in Salicylate‐induced Tinnitus with an Online Electrochemical System

Paradoxical kinesia in Parkinson’s disease: theories and practical application

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