Deep brain stimulation in dystonia: State of art and future directions

Macerollo, Antonella; Sajin, Valeria; Bonello, Michael; Barghava, D.; Alusi, Sundus; Eldridge, Paul; Osman-Farah, Jibril

doi:10.1016/j.jneumeth.2020.108750

Cited by 15 publications

(7 citation statements)

References 180 publications

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“…Other therapies were also proposed, particularly deep brain stimulation which was used in segmental and generalized dystonia. However, high-evidence studies are still lacking with this therapeutic option [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Hypertonia of the Big Toe Revealing Parkinson’s Disease: A Case Report

Mahla,

Rhoul,

Gartit

et al. 2024

Cureus

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Despite being less commonly discussed than other motor symptoms such as tremors and bradykinesia, hypertonia of the hallux holds diagnostic and prognostic significance in Parkinson's disease (PD). This motor anomaly is dissected within the context of the broader clinical spectrum of PD symptoms, emphasizing its importance alongside its cardinal symptoms. This case report underscores the importance of accurate clinical assessment especially thorough neurological evaluation in discerning hallux hypertonia, potentially enabling early disease recognition and intervention. By synthesizing these clinical insights, we trust that this case report contributes to an enhanced understanding of hypertonia of the hallux as a distinctive clinical presentation in PD fostering improved diagnostic precision.

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Section: Discussionmentioning

confidence: 99%

Hypertonia of the Big Toe Revealing Parkinson’s Disease: A Case Report

Mahla,

Rhoul,

Gartit

et al. 2024

Cureus

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“…Despite the fact that HD patients can suffer from severe and heterogeneous dysarthria and dysphagia [19], speech was not monitored in detail in any of the reviewed studies on DBS in HD. This is surprising, because the appearance or worsening of dysarthria, dysphagia and stuttering are known complications of DBS treatment in other indications [20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Is deep brain stimulation effective in Huntington’s Disease? — a systematic literature review

Kaczyńska

Sitek

Witkowski

et al. 2022

Neurol Neurochir Pol.

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Introduction. Huntington's Disease (HD) is an autosomal dominant neurodegenerative disorder. Substantial for a diagnosis of the disease are motor disorders, with chorea as a hallmark symptom. Other disease manifestations include cognitive dysfunction and psychiatric disorders. Currently, pharmacological treatment plays the most important role in the therapy of HD patients. However, deep brain stimulation (DBS) is considered a potential therapeutic option.Aim of the study. Systematic review of current literature on DBS efficacy and safety in the management of motor, behavioural and cognitive functions in patients with HD. Material and methods.A systematic review was conducted with the use of the Scopus database and the following search criteria: TITLE (huntington*) AND TITLE-ABS-KEY ('deep brain stimulation' OR 'neuromodulation'). Our search criteria included original studies with at least five patients, reporting any motor, cognitive and/or behavioural, and functional assessment data with at least a 6-month follow-up. Finally, four selected publications were analysed.Results. In all analysed publications, we found a statistically significant improvement of Unified Huntington's Disease Rating Scale (UHDRS) chorea subscore by an average of 40, to over 60% after DBS implantation. Heterogeneous results were obtained for UHDRS total motor score. DBS did not improve functional capacity of HD patients in the analysed studies. We found no systematic assessment concerning the effect of DBS in HD on behaviour, cognition or speech.Conclusions. DBS implantation could be considered as a therapeutic option for patients with severe, drug-resistant chorea. However, the evidence for this is limited. To date, no high-quality data based on randomised controlled trials supports the long-term safety and efficacy of DBS in HD. This treatment option should therefore currently be considered as investigational.

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“…STN DBS is an interesting target for treating dystonia [ 179 , 180 ]. A recent meta-analysis comparing the efficacy of high-frequency STN DBS and GPi DBS suggested that STN DBS is more efficient at suppressing dystonia than GPi DBS in the long term [ 181 ].…”

Section: Research Regarding the Role Of The Cerebellum In Dystonia Genesismentioning

confidence: 99%

Dystonia and Cerebellum: From Bench to Bedside

Morigaki

Miyamoto

Matsuda

et al. 2021

Life

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Dystonia pathogenesis remains unclear; however, findings from basic and clinical research suggest the importance of the interaction between the basal ganglia and cerebellum. After the discovery of disynaptic pathways between the two, much attention has been paid to the cerebellum. Basic research using various dystonia rodent models and clinical studies in dystonia patients continues to provide new pieces of knowledge regarding the role of the cerebellum in dystonia genesis. Herein, we review basic and clinical articles related to dystonia focusing on the cerebellum, and clarify the current understanding of the role of the cerebellum in dystonia pathogenesis. Given the recent evidence providing new hypotheses regarding dystonia pathogenesis, we discuss how the current evidence answers the unsolved clinical questions.

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Deep brain stimulation in dystonia: State of art and future directions

Cited by 15 publications

References 180 publications

Hypertonia of the Big Toe Revealing Parkinson’s Disease: A Case Report

Hypertonia of the Big Toe Revealing Parkinson’s Disease: A Case Report

Is deep brain stimulation effective in Huntington’s Disease? — a systematic literature review

Dystonia and Cerebellum: From Bench to Bedside

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