Deep brain stimulation in addiction due to psychoactive substance use

Optimizing Deep Brain Stimulation of the Nucleus Accumbens in a Reward Preference Rat Model

“…To our knowledge, this is the first study to rigorously compare rats' preferences for a range of different stimulation paradigms against each other, and is also the first study to employ “rat‐initiated” DBS, combining prolonged periods of DBS with a behavioral indication of levels of motivation, through the ongoing association between the lever press and reward initiation. Furthermore, although this study was not designed to directly assess the therapeutic value of the different patterns of stimulation tested, both animal and human studies indicate DBS of the NAc as a promising therapy for addictive disorders (see Kuhn et al ), OCD , anorexia nervosa , and major depression , and our findings may therefore guide future clinical applications of NAc DBS for treating addiction and other neurological and psychiatric disorders.…”

“Killing Two Birds with One Stone”: Alcohol Use Reduction Interventions with Potential Efficacy at Enhancing Self-control

“…However, DBS has been applied to several neurobehavioral disorders and based on its utility in modulating dysregulated brain networks, it is of growing interest in the addictions [130]. Alleviation of comorbid AUD was also reported in the initial case report of DBS in the nucleus accumbens to treat severe anxiety and depression [131].…”

Optogenetic dissection of neural circuitry: from synaptic causalities to blue prints for novel treatments of behavioral diseases

“…In the field of addiction, DBS has been used in a few instances to reduce symptoms of craving in severely treatment-refractive patients [48,49]. However, the effects are variable and transient.…”