Optimizing Deep Brain Stimulation of the Nucleus Accumbens in a Reward Preference Rat Model

Evans, Maggie C.; Clark, Vincent W.; Manning, Patrick J.; Ridder, Dirk De; Reynolds, John N. J.

doi:10.1111/ner.12339

Cited by 6 publications

(4 citation statements)

References 34 publications

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“…Previous studies have reported on the responses of rats to electrical stimulation of the ventral posterolateral nucleus of the thalamus using various stimulation parameters [20]. Specifically, it has been reported that rats respond more robustly to burst rather than tonic pattern stimulation [32], as we have also shown here. Neurochemical study has indicated that burst pattern stimulation causes a greater release of dopamine from the nucleus accumbens than does tonic stimulation [33].…”

Section: Discussionsupporting

confidence: 72%

Optimization of Medial Forebrain Bundle Stimulation Parameters for Operant Conditioning of Rats

Kong

Shin

Koh

et al. 2019

Stereotact Funct Neurosurg

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Background: The medial forebrain bundle (MFB) is involved in the integration of pleasure and reward. Previous studies have used various stimulation parameters for operant conditioning, though the effectiveness of these parameters has not been systematically studied. Objectives: The purpose of the present study was to investigate the optimal MFB stimulation parameters for controlling the conditioned behavior of rats. Methods: We evaluated four factors, including intensity, frequency, pulse duration, and train duration, to determine the effect of each on lever pressure applied by animals. We further compared burst and tonic stimulation in terms of learning and performance abilities. Results: The number of lever presses increased with each factor. Animals in the burst stimulation group exhibited more lever presses. Furthermore, the average speed in the 田 maze among burst stimulation group subjects was higher. Conclusion: We determined the optimal parameters for movement control of animals in operant conditioning and locomotor tasks by adjusting various electrical stimulation parameters. Our results reveal that a burst stimulation is more effective than a tonic stimulation for increasing the moving speed and number of lever presses. The use of this stimulation technique also allowed us to minimize the training required to control animal behavior.

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Section: Discussionsupporting

confidence: 72%

Optimization of Medial Forebrain Bundle Stimulation Parameters for Operant Conditioning of Rats

Kong

Shin

Koh

et al. 2019

Stereotact Funct Neurosurg

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“…However, to develop reconditioning stimulation, very specific waveforms need to be developed that give maximal reward by stimulating the nucleus accumbens or give maximal disreward by stimulating the habenula. A technique has been developed in animals based on self‐stimulation that can discriminate which waveform or stimulation design rats prefer over others, thereby optimizing the waveform to the target . As the nucleus accumbens and anterior cingulate cortex in rats and humans seems to respond in similar ways (in studies analyzing the reward system in pain) , it can be assumed that translating animal data to humans is worthwhile.…”

Section: Future Of Psychosurgerymentioning

confidence: 99%

Psychosurgery Reduces Uncertainty and Increases Free Will? A Review

Ridder

Vanneste

Gillett

et al. 2016

Neuromodulation: Technology at the Neural Interface

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“…However, in order to develop reconditioning stimulation waveforms need to be developed that give maximal reward by stimulating the nucleus accumbens or give maximal disreward by stimulating the habenula. A technique has been developed in animals based on self-stimulation that can discriminate which waveform or stimulation design rats prefer over others, thereby optimizing the waveform to the target [65].…”

Section: Reconditioning Stimulationmentioning

confidence: 99%

Visions on the future of medical devices in spinal cord stimulation: what medical device is needed?

Ridder

Vanneste

2016

Expert Review of Medical Devices

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Recently burst stimulation and 10 kHz stimulation have been developed as novel stimulation designs. Both appear to be superior to classical tonic stimulation in the amount of responders and the amount of pain suppression and have as an extra advantage that they are paresthesia-free. This evolution is very important as it shifts the focus of research from better targeting by developing new lead configurations to better communication with the nervous system. It can be envisioned that this is only the start of a new trend in spinal cord, brain, and peripheral nerve stimulation and that more new stimulation designs will be developed in the near future such as pseudorandom burst stimulation, pleasure stimulation, noise stimulation and reconditioning stimulation. This evolution mandates a new approach in the development of internal pulse generators, and the most obvious approach is to develop an upgradable stimulator, on which new stimulation designs can be downloaded, analogous to the apps people download on their smartphones. This will create a shift from hardware driven products to software driven stimulators.

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Optimizing Deep Brain Stimulation of the Nucleus Accumbens in a Reward Preference Rat Model

Cited by 6 publications

References 34 publications

Optimization of Medial Forebrain Bundle Stimulation Parameters for Operant Conditioning of Rats

Optimization of Medial Forebrain Bundle Stimulation Parameters for Operant Conditioning of Rats

Psychosurgery Reduces Uncertainty and Increases Free Will? A Review

Visions on the future of medical devices in spinal cord stimulation: what medical device is needed?

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