Deep Brain Stimulation for Treatment of Refractory Epilepsy

Oliveira, Tatiana von Hertwig Fernandes de; Cukiert, Arthur

doi:10.4103/0028-3886.310083

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Basic mechanisms behind DBS effects on seizures are not fully understood, but it has been hypothesized that stimulation reduces propagation of ictal (and inter‐ictal) epileptic activity in the Circle of Papez, of which ANT is a part 11 . As seizure reduction during ANT stimulation is a possible indicator of network normalization, it is reasonable to assume that patients who have seizure reduction also can have improved cognitive performance.…”

Section: Discussionmentioning

confidence: 99%

Cognitive change after DBS in refractory epilepsy: A randomized‐controlled trial

Heminghyt

Herrman

Skogan

et al. 2021

Acta Neuro Scandinavica

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Objectives Deep brain stimulation of the anterior thalamic nucleus (ANT‐DBS) reduces seizure frequency in patients with refractory epilepsy. There are, however, few studies on treatment‐related changes in cognitive functions. The main objective of this study was to investigate cognitive changes in patients receiving ANT‐DBS. We also explored whether possible effects were related to stimulation duration and whether change in seizure frequency was associated with cognitive changes. Materials and methods Bilateral ANT electrodes were implanted in 18 patients with refractory epilepsy, aged 18–52 years. Immediately after implantation, patients were randomized to stimulation ON (n = 8) or OFF (n = 10) for the first 6 months (blinded phase). During the following 6‐month open phase, both groups received stimulation. Neuropsychological assessments were conducted before implantation (T1), at the end of the blinded period (T2), and 1 year after implantation (T3). Results Groupwise comparisons across the three time points revealed changes in performance in two of 22 cognitive test scores: motor speed and sustained attention. We found no significant group differences in cognitive change from T1 to T2. Patients reported fewer symptoms of executive dysfunction after 12 months of stimulation. Patients showing significant improvement in seizure frequency had better performance in a measure of verbal learning. Conclusion Our results indicate that ANT‐DBS has very limited effects on cognitive functioning, as measured by formal tests after 6‐ or 12‐month stimulation. ANT‐DBS may have a positive influence on executive function. Our findings provide limited support for an association between change in seizure frequency and cognitive functioning.

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Section: Discussionmentioning

confidence: 99%

Cognitive change after DBS in refractory epilepsy: A randomized‐controlled trial

Heminghyt

Herrman

Skogan

et al. 2021

Acta Neuro Scandinavica

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An Audit of the Quality of Reporting and Bias of Studies on Yoga in Epilepsy

2022

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Background: Yoga is increasingly being used as a complementary mode of treatment for epilepsy along with pharmacotherapy; however, the quality of reporting and bias of studies on yoga in epilepsy is uncertain. Objective: This study was performed to systematically evaluate the reporting quality and bias of the published studies on yoga in epilepsy. Materials and methods: PubMed and Cochrane databases were searched for studies investigating the efficacy of yoga in epilepsy or describing the patients' or caregivers' knowledge, attitude, influence, and practice of yoga in epilepsy. The reporting qualities of the studies were appraised by standard reporting checklists (CONSORT, STROBE, COREQ, and modified CONSORT) and the risks of bias were assessed using standard tools (Cochrane Collaboration's risk of bias tool, Newcastle-Ottawa scale, and ROBINS-I tool) according to the study designs. Results: Fifteen studies (four randomized control trials, seven observational studies, three non-randomized interventional studies, and one was a mixed-method study) were included. The reporting qualities of the studies which evaluated the role of yoga in epilepsy were comparatively poor from the methodological perspective and the risks of bias were comparatively high than those which described the knowledge, attitude, influence, and practice of yoga in epilepsy. Conclusion: The reporting qualities of studies in relation to yoga and epilepsy were not satisfactory and the risks of bias were high. Hence, it is imperative to be cautious before widely recommending yoga in epilepsy.

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Deep Brain Stimulation for Treatment of Refractory Epilepsy

Cited by 2 publications

References 15 publications

Cognitive change after DBS in refractory epilepsy: A randomized‐controlled trial

Cognitive change after DBS in refractory epilepsy: A randomized‐controlled trial

An Audit of the Quality of Reporting and Bias of Studies on Yoga in Epilepsy

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