Deep brain stimulation by optimized stimulators in a phenotypic model of dystonia: Effects of different frequencies

Paap, Maria; Perl, Stefanie; Lüttig, Anika; Plocksties, Franz; Niemann, Christoph; Timmermann, Dirk; Bahls, Christian; Rienen, Ursula van; Franz, Denise; Zwar, Monique; Rohde, Marco; Köhling, Rüdiger; Richter, Angelika

doi:10.1016/j.nbd.2020.105163

Cited by 11 publications

(12 citation statements)

References 28 publications

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“…Hence, we did not further consider current-controlled monophasic waveforms because potentially harmful electrochemical reactions cannot be excluded. Simple reasoning for this DC offset, which has also been reported elsewhere (Paap et al, 2021), can be given based on the results presented in Section 3.2.1. The employed monophasic pulse with an amplitude of 6.5 mA, a pulse width of 60 µs, and a frequency of 130 Hz has a DC component of 50.7 µA.…”

Section: Rectangular Wave Stimulation-broadband Impedance Spectroscopymentioning

confidence: 83%

“…For this reason, current-controlled pulses are often preferred over voltage-controlled pulses because the applied stimulation field strength is proportional to the current density but not to the applied voltage. The aforementioned DC voltage offset that appears for current-controlled monophasic pulses can then be removed using charge-balancing approaches ( Paap et al, 2021 ), which we did not cover in this work.…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the hardware, the current measurement could be improved by using a better amplifier. Potentially, the approach can be integrated into implantable stimulators such as presented in Paap et al (2021) . In comparison to the guideline suggested in Boehler et al (2020) , we did not determine the water window of the electrode system (i.e., the potential region in which neither water oxidation nor reduction occurs).…”

Section: Discussionmentioning

confidence: 99%

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Using a Digital Twin of an Electrical Stimulation Device to Monitor and Control the Electrical Stimulation of Cells in vitro

Zimmermann

Budde

Arbeiter

et al. 2021

Front. Bioeng. Biotechnol.

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Electrical stimulation for application in tissue engineering and regenerative medicine has received increasing attention in recent years. A variety of stimulation methods, waveforms and amplitudes have been studied. However, a clear choice of optimal stimulation parameters is still not available and is complicated by ambiguous reporting standards. In order to understand underlying cellular mechanisms affected by the electrical stimulation, the knowledge of the actual prevailing field strength or current density is required. Here, we present a comprehensive digital representation, a digital twin, of a basic electrical stimulation device for the electrical stimulation of cells in vitro. The effect of electrochemical processes at the electrode surface was experimentally characterised and integrated into a numerical model of the electrical stimulation. Uncertainty quantification techniques were used to identify the influence of model uncertainties on relevant observables. Different stimulation protocols were compared and it was assessed if the information contained in the monitored stimulation pulses could be related to the stimulation model. We found that our approach permits to model and simulate the recorded rectangular waveforms such that local electric field strengths become accessible. Moreover, we could predict stimulation voltages and currents reliably. This enabled us to define a controlled stimulation setting and to identify significant temperature changes of the cell culture in the monitored voltage data. Eventually, we give an outlook on how the presented methods can be applied in more complex situations such as the stimulation of hydrogels or tissue in vivo.

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Section: Rectangular Wave Stimulation-broadband Impedance Spectroscopymentioning

confidence: 83%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Using a Digital Twin of an Electrical Stimulation Device to Monitor and Control the Electrical Stimulation of Cells in vitro

Zimmermann

Budde

Arbeiter

et al. 2021

Front. Bioeng. Biotechnol.

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“…Patients with dystonia had lower beta power but higher low frequency and high gamma power than PD, and its mean firing rate was lower compared to PD ( 22 - 24 ). Local field potential activity less than 10 Hz has been observed in coherence with dystonic movement ( 25 , 26 ). It has been hypothesized that stimulation frequencies exceeding the firing rate and the mean oscillatory activity of the target in dystonia (~50 Hz) would be enough to modulate this abnormal electrical activity and dystonic movements ( 25 , 26 ), which may be the reason why 60 Hz STN-DBS is effective for this patient.…”

Section: Discussionmentioning

confidence: 99%

“…Local field potential activity less than 10 Hz has been observed in coherence with dystonic movement ( 25 , 26 ). It has been hypothesized that stimulation frequencies exceeding the firing rate and the mean oscillatory activity of the target in dystonia (~50 Hz) would be enough to modulate this abnormal electrical activity and dystonic movements ( 25 , 26 ), which may be the reason why 60 Hz STN-DBS is effective for this patient. However, we cannot provide a reason for the limited success of the high frequency STN-DBS.…”

Section: Discussionmentioning

confidence: 99%

Low frequency subthalamic nucleus electrical stimulation relieves the symptoms of DYT1-dystonia: a case description

Fan

Shi

Zhang

et al. 2022

Quant Imaging Med Surg

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Role of HCN channels in the functions of basal ganglia and Parkinson’s disease

Qi,

Yan,

Fan

et al. 2024

Cell. Mol. Life Sci.

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Parkinson's disease (PD) is a motor disorder resulting from dopaminergic neuron degeneration in the substantia nigra caused by age, genetics, and environment. The disease severely impacts a patient’s quality of life and can even be life-threatening. The hyperpolarization-activated cyclic nucleotide-gated (HCN) channel is a member of the HCN1-4 gene family and is widely expressed in basal ganglia nuclei. The hyperpolarization-activated current mediated by the HCN channel has a distinct impact on neuronal excitability and rhythmic activity associated with PD pathogenesis, as it affects the firing activity, including both firing rate and firing pattern, of neurons in the basal ganglia nuclei. This review aims to comprehensively understand the characteristics of HCN channels by summarizing their regulatory role in neuronal firing activity of the basal ganglia nuclei. Furthermore, the distribution and characteristics of HCN channels in each nucleus of the basal ganglia group and their effect on PD symptoms through modulating neuronal electrical activity are discussed. Since the roles of the substantia nigra pars compacta and reticulata, as well as globus pallidus externus and internus, are distinct in the basal ganglia circuit, they are individually described. Lastly, this investigation briefly highlights that the HCN channel expressed on microglia plays a role in the pathological process of PD by affecting the neuroinflammatory response.

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Deep brain stimulation by optimized stimulators in a phenotypic model of dystonia: Effects of different frequencies

Cited by 11 publications

References 28 publications

Using a Digital Twin of an Electrical Stimulation Device to Monitor and Control the Electrical Stimulation of Cells in vitro

Using a Digital Twin of an Electrical Stimulation Device to Monitor and Control the Electrical Stimulation of Cells in vitro

Low frequency subthalamic nucleus electrical stimulation relieves the symptoms of DYT1-dystonia: a case description

Role of HCN channels in the functions of basal ganglia and Parkinson’s disease

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