Role of HCN channels in the functions of basal ganglia and Parkinson’s disease
Zeng-Xin Qi,
Qi Yan,
Xiu-Juan Fan
et al.
Abstract:Parkinson's disease (PD) is a motor disorder resulting from dopaminergic neuron degeneration in the substantia nigra caused by age, genetics, and environment. The disease severely impacts a patient’s quality of life and can even be life-threatening. The hyperpolarization-activated cyclic nucleotide-gated (HCN) channel is a member of the HCN1-4 gene family and is widely expressed in basal ganglia nuclei. The hyperpolarization-activated current mediated by the HCN channel has a distinct impact on neuronal excita… Show more
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