Dedifferentiation occurring in adenoid cystic carcinoma of the tongue

Moles, M.A. González; Avila, Isabel Ruiz; Archilla, Alberto Rodriguez

doi:10.1016/s1079-2104(99)70114-9

Cited by 44 publications

(3 citation statements)

References 14 publications

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“…Of these, 17 occurred in minor salivary glands of tongue, palate and sinonasal tract including a tumor in the hypopharynx [5, 6, 8–10]. Seven tumors occurred in the submandibular gland [7, 9, 10].…”

Section: Discussionmentioning

confidence: 99%

High Grade Transformation in Adenoid Cystic Carcinoma of the Parotid: Report of a Case with Cytologic, Histologic and Immunohistochemical Study

Malhotra

Agrawal

Pandey

2009

Head and Neck Pathol

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Adenoid cystic carcinoma (ACC) constitutes about 4% of salivary epithelial tumors and is the second common malignant epithelial salivary gland tumor involving both the major and minor salivary glands. High grade transformation in ACC is a recently recognized entity with only a few cases reported in literature. We report the first case of ACC with high grade transformation involving the parotid. A 54-year-old man with a history of right parotid painful swelling from 1.5 years presented with recent increase in size of the swelling and facial paresis of 2 months duration. The locally invasive salivary neoplasm was composed predominantly of an undifferentiated carcinoma with foci of conventional ACC occupying less than 10% of tumor area. Immunohistochemical study of the undifferentiated component as compared to conventional ACC showed greater over-expression of p53 and Ki-67. Her-2/Neu was negative in both components. Recognition of occasional clusters of basaloid cells and hyaline globules in association with larger poorly differentiated malignant cell population in aspiration smears can help in cytological diagnosis. The acquisition of high proliferation index and over-expression of p53 may be the probable factors involved in the pathogenesis of high grade transformation in a conventional ACC.

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Section: Discussionmentioning

confidence: 99%

High Grade Transformation in Adenoid Cystic Carcinoma of the Parotid: Report of a Case with Cytologic, Histologic and Immunohistochemical Study

Malhotra

Agrawal

Pandey

2009

Head and Neck Pathol

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“…The presence and extent of the solid pattern (currently with a cutoff of 30%) portend an accelerated and worse clinical course 45,46. Since the original description of 3 cases of HGT/dedifferentiation in AdCCs (both de novo and in recurrences) by Cheuk et al,10 >50 cases have now been published 11,12,47–55…”

Section: Acinic Cell Carcinomamentioning

confidence: 99%

“…45,46 Since the original description of 3 cases of HGT/dedifferentiation in AdCCs (both de novo and in recurrences) by Cheuk et al, 10 > 50 cases have now been published. 11,12,[47][48][49][50][51][52][53][54][55] The histologic hallmarks of HGT in AdCC include necrosis, high mitotic rate, and loss of the biphasic ductalmyoepithelial differentiation. 10 It is mainly the cytomorphologic features that allow for a distinction between AdCC-HGT and the solid pattern of AdCC.…”

Section: Adenoid Cystic Carcinomamentioning

confidence: 99%

High-grade Transformation/Dedifferentiation in Salivary Gland Carcinomas: Occurrence Across Subtypes and Clinical Significance

Skálová¹,

Leivo

Hellquist

et al. 2021

Advances in Anatomic Pathology

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High-grade transformation (HGT) or dedifferentiation has been described in a variety of salivary gland carcinomas, including acinic cell carcinoma, secretory carcinoma, adenoid cystic carcinoma, epithelial-myoepithelial carcinoma, polymorphous adenocarcinoma, low-grade mucoepidermoid carcinoma, and hyalinizing clear cell carcinoma. High-grade (HG) transformed tumors are composed of a conventional low-grade component characterized by specific microscopic and immunohistochemical features for the given entity, intermingled with or juxtaposed to areas of HG morphology. This is usually either poorly differentiated adenocarcinoma, carcinoma not otherwise specified, or undifferentiated carcinoma, in which the original line of differentiation is lost. The HG component is composed of solid nests of anaplastic cells with large vesicular pleomorphic nuclei, prominent nucleoli, and abundant cytoplasm. Frequent mitoses and extensive necrosis may be present. The Ki-67 labeling index is consistently higher in the HG component. The molecular genetic mechanisms responsible for HGT of salivary gland carcinomas are largely unknown, though p53 inactivation and human epidermal growth factor receptor 2 overexpression and/or gene amplification have been demonstrated in the HG component in a few examples, the frequency varies for each histologic type. Salivary gland carcinomas with HGT are more aggressive than conventional carcinomas, with a higher local recurrence rate and a poorer prognosis. They have a high propensity for cervical lymph node metastasis suggesting a need for a wider resection and neck dissection. HGT of salivary gland carcinoma can occur either at initial presentation or less commonly at the time of recurrence, sometimes following postoperative radiotherapy. The potential for HGT in almost any type of salivary gland carcinoma warrants a thorough sampling of all salivary gland malignancies to prevent oversight of a HG component.

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Epithelial Lacrimal Gland Tumors

Weis

Rootman²,

Joly³

et al. 2009

Arch Ophthalmol

124

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To apply the updated epithelial salivary gland classification scheme to a large cohort of lacrimal gland tumors so as to provide an updated lacrimal gland tumor classification scheme. Methods: A retrospective multicenter cohort study of 118 cases of epithelial neoplasia was undertaken. Main outcome measures included pathologic analysis, subtyping, and survival. Results: Of 118 cases, 17 (14%) were reclassified using the proposed expanded classification scheme based on the current World Health Organization classification of salivary gland tumors. The most frequent neoplasms were pleomorphic adenoma and adenoid cystic carcinoma, of which we highlight more unusual histologic features. Three tumors were found to be unclassifiable with the updated scheme, with 2 having histologically malignant features. Deficiencies and variations in pathologic assessment were noted. Variation in the histologic findings of pleomorphic adenoma and assessment of the extent of invasion of carcinoma ex pleomorphic adenoma were highlighted. Conclusions: The use of the more histologically diverse classification of salivary gland tumors can be successfully applied to the epithelial lacrimal gland neoplasms. This expanded classification system led to reclassifying 14% of cases. Currently, there are no consistent pathologic standards for processing and evaluating these lesions.

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Dedifferentiation occurring in adenoid cystic carcinoma of the tongue

Cited by 44 publications

References 14 publications

High Grade Transformation in Adenoid Cystic Carcinoma of the Parotid: Report of a Case with Cytologic, Histologic and Immunohistochemical Study

High Grade Transformation in Adenoid Cystic Carcinoma of the Parotid: Report of a Case with Cytologic, Histologic and Immunohistochemical Study

High-grade Transformation/Dedifferentiation in Salivary Gland Carcinomas: Occurrence Across Subtypes and Clinical Significance

Epithelial Lacrimal Gland Tumors

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