Dedifferentiated liposarcoma of the retroperitoneum with osteosarcomatous component: report of two cases

Toshiyasu, Takashi; Ehara, Shigeru; Yamaguchi, Takehiko; Nishida, Jun; Shiraishi, Hideo

doi:10.1016/j.clinimag.2008.04.009

Cited by 11 publications

(6 citation statements)

References 11 publications

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“…Our case of dedifferentiated liposarcoma with osteosarcomatous dedifferentiation represents an extremely rare entity with, to our knowledge, fewer than ten reported cases in the literature ( 2 , 5 , 6 , 7 , 8 ). In general, DDL appears as a heterogeneous mass adjacent to variable amounts of mature fatty elements.…”

Section: Discussionmentioning

confidence: 68%

Retroperitoneal dedifferentiated liposarcoma with osteosarcomatous dedifferentiation

Nguyen

Shaves

Winston

2013

Radiology Case Reports

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Section: Discussionmentioning

confidence: 68%

Retroperitoneal dedifferentiated liposarcoma with osteosarcomatous dedifferentiation

Nguyen

Shaves

Winston

2013

Radiology Case Reports

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“…4 Toshiyasu et al, in a study conducted in 2009, described 2 similar cases, which were added to a list of other 7 cases previously reported in the literature. 5 Subsequently, in 2013, Fujii et al reported their own case and, by reviewing the literature on the topic, they found 4 additional cases of DDLS with osteosarcomatous components, for a total of 14 cases. 6 To the best of our knowledge, no other cases of DDLS with osteosarcomatous component have been reported so far in the English literature, and so our case is the 16th case.…”

Section: Discussionmentioning

confidence: 99%

Dedifferentiated Liposarcoma of Retroperitoneum With Extensive Osteosarcomatous Component

Trombatore

Caltabiano

Giovanni

et al. 2016

International Surgery

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Dedifferentiated liposarcoma (DDLS) is a rare subtype of liposarcoma composed of 2 components: a well-differentiated liposarcoma (WDLS) and a nonlipogenic sarcoma (dedifferentiation component), represented in .90% of cases by a high grade undifferentiated pleomorphic sarcoma, in the form of both small microscopic foci and/ or grossly recognizable nodular masses. The paper reports a rare case of a retroperitoneal DDLS, in which approximately half of a tumor mass is composed of a high-grade osteosarcoma. A 68-year-old Caucasian woman affected by abdominal discomfort. Clinical examination showed a large, hard and fixed abdominal mass. Computed tomography scan revealed a huge retroperitoneal mass composed of 2 distinct components: the upper part showed a hypodense tissue, while the lower part showed a higher density and coarse calcifications. Patient underwent to a challenging surgical resection of the mass that, at histological examination, resulted to be a DDLS, in which a WDLS coexisted with an osteosarcoma. Presurgical diagnosis of DDLS is difficult due to the great morphologic variability of the dedifferentiated component, ranging from low to high-grade nonlipogenic sarcoma. The present case contributes to widen the morphological spectrum of DDLS, emphasizing the possibility that a retroperitoneal mass with a

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“…A similar principle applies to MRI [13]. However, once a DDLS contains osseous or cartilaginous elements, the radiological diagnosis becomes challenging [14][15][16] and in the head and neck region the differential diagnosis of a teratoma becomes especially difficult. Moreover, (and as highlighted by our case) when a DDLS (or WDLS) contains abundant-predominant myxoid stroma (which is not an exceedingly rare event) [17], the radiological features may not point towards a neoplasm within the spectrum of adipocytic tumors.…”

Section: Discussionmentioning

confidence: 99%

Dedifferentiated Liposarcoma of the Deep (Paralaryngeal) Soft Tissue: Lessons Learnt from a Case with a Partly Deceptively Benign Appearing Dedifferentiated Component

Petersson

Murugasu

2013

Head and Neck Pathol

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We present a case (female, 61 years of age) of dedifferentiated liposarcoma of the deep, cervical (paralaryngeal) soft tissue with a significant myxoid component and characteristic immunohistochemical (strong and diffuse expression of p16, mdm2 and cdk4 in both the well differentiated liposarcomatous and dedifferentiated components) and molecular genetic findings (MDM2-gene amplification on fluorescence in situ hybridization). The myxoid component which was present in the well differentiated liposarcomatous component gave the tumor atypical radiological features. The case presented initial diagnostic difficulties, mainly because of the bland histomorphological appearance of the limited biopsy material from the sampled non-lipogenic, dedifferentiated component. The dedifferentiated part of the tumor turned out to harbor significant heterogeneity with regards to cellularity, cytomorphology and proliferative activity.

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Dedifferentiated liposarcoma of the retroperitoneum with osteosarcomatous component: report of two cases

Cited by 11 publications

References 11 publications

Retroperitoneal dedifferentiated liposarcoma with osteosarcomatous dedifferentiation

Retroperitoneal dedifferentiated liposarcoma with osteosarcomatous dedifferentiation

Dedifferentiated Liposarcoma of Retroperitoneum With Extensive Osteosarcomatous Component

Dedifferentiated Liposarcoma of the Deep (Paralaryngeal) Soft Tissue: Lessons Learnt from a Case with a Partly Deceptively Benign Appearing Dedifferentiated Component

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