Retroperitoneal dedifferentiated liposarcoma with osteosarcomatous dedifferentiation

Nguyen, Vina P.; Shaves, Sarah; Winston, Janet S.

doi:10.2484/rcr.v8i3.425

Cited by 1 publication

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References 11 publications

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“…[ 1 , 6 ] But a few cases reported that RPDDL appeared as the huge cystic degeneration or contained the osteosarcomatous components with extensive calcification. [ 14 , 18 , 19 ] Furthermore, positron emission tomography-computed tomography (PET-CT) can be performed to estimate tumor grade and to obtain information on metastases. [ 11 ] Because of its high cost, only a small number of patients, to our knowledge, agree to use it in our country.…”

Section: Discussionmentioning

confidence: 99%

Recurrence of locally invasive retroperitoneal dedifferentiated liposarcoma shortly after surgery: A case report and literature review

Hu,

Han,

Yang

et al. 2024

Medicine

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Rationale: Retroperitoneal dedifferentiated liposarcoma (RPDDL) is an uncommon malignancy, which often remains undetected for many years due to having adequate space in the retroperitoneal cavity and lacking clinical manifestations in the early stage of the disease. Surgical procedure is usually used as the first choice for treatment. However, it is prone to local recurrence after the operation, resulting in an unfavorable prognosis. Our aim is to draw useful lessons from the new case and provide some experience for management of the disease. Patient concerns: We describe a 55-year-old male patient who was admitted for a 3-week history of persistent dull ache of the left waist. A large mass of the left upper abdomen was palpated in physical examination. Moreover, the imaging examination revealed that the diameter of the mass was about 21 cm, and some adjacent vital organs were invaded, which brought great challenges to complete surgical resection. Diagnosis: The postoperative pathological results confirmed that the mass was RPDDL with invasion of the surrounding vital structures including pancreas, spleen, left adrenal gland, left kidney, and vasculature with tumor emboli. Interventions: Surgical resection of the mass was performed by our multidisciplinary team. The patient received chemotherapy 1 month after surgery. Outcomes: The effect of chemotherapy seemed to be unsatisfactory. Local multifocal recurrence of the tumor was considered about 2 months after surgery. Finally, he gave up any treatments and died of the disease. Lessons: Regular physical examination and ultrasound screening may detect the disease as early as possible, especially for high-risk group aged 60 to 70, which should be popularized. Incomplete resection, vascular invasion, and interruption of postoperative treatment may lead to an unfavorable prognosis. Therefore, we think that patients with the disease may benefit from complete surgical resection and uninterrupted adjuvant therapy.

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Section: Discussionmentioning

confidence: 99%

Recurrence of locally invasive retroperitoneal dedifferentiated liposarcoma shortly after surgery: A case report and literature review

Hu,

Han,

Yang

et al. 2024

Medicine

View full text Add to dashboard Cite

show abstract

Retroperitoneal dedifferentiated liposarcoma with osteosarcomatous dedifferentiation

Abstract: We present a case of a dedifferentiated liposarcoma with osteosarcomatous degeneration in a 46-year-old male. The mass, palpated during a routine physical exam, was analyzed with dynamic, contrast-enhanced CT and CT-guided core-needle biopsy before surgical resection.

Cited by 1 publication

References 11 publications

Recurrence of locally invasive retroperitoneal dedifferentiated liposarcoma shortly after surgery: A case report and literature review

Recurrence of locally invasive retroperitoneal dedifferentiated liposarcoma shortly after surgery: A case report and literature review

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