Dedifferentiated epithelial-myoepithelial carcinoma of the parotid gland: a rare case report of immunohistochemical analysis and review of the literature

Kusafuka, Kimihide; Takizawa, Yoshinori; Ueno, Takao; Ishiki, Hiroto; Asano, Rie; Kamijo, Tomoyuki; Iida, Yoshiyuki; Ebihara, Mitsuru; Ota, Yojiro; Onitsuka, Tetsuro; Kameya, Toru

doi:10.1016/j.tripleo.2008.01.013

Cited by 56 publications

(54 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, dedifferentiation also happens during some rare pathological occasions, which has been found in skeletal neoplasms such as osteosarcoma [36] and chondrosarcoma [37]. Kusafuka [38] recently reported a case of dedifferentiated epithelial-myoepithelial carcinoma (EMC) in the parotid region, based on the dedifferentiation of vascular smooth muscle cells. For the adipose tissue, a 20-year survey on the soft tissue sarcoma reported that 5 cases out of 5 333 have been identified as dedifferentiated liposarcoma, while the overall number of liposarcoma was 652 [39].…”

Section: Establishment Of Dfat Cellsmentioning

confidence: 99%

Dedifferentiated fat cells: an alternative source of adult multipotent cells from the adipose tissues

et al. 2011

View full text Add to dashboard Cite

Section: Establishment Of Dfat Cellsmentioning

confidence: 99%

Dedifferentiated fat cells: an alternative source of adult multipotent cells from the adipose tissues

et al. 2011

View full text Add to dashboard Cite

“…Dedifferentiation in salivary gland carcinomas other than ADCC is a rare but well recognized phenomenon and has been documented in epithelial-myoepithelial carcinoma (EMECa) [34][35][36][37][38], acinic cell carcinoma [39][40][41][42][43][44], mucoepidermoid carcinoma [45,46], polymorphous low-grade adenocarcinoma [47,48], hyalinizing clear cell carcinoma [49] and salivary duct carcinoma [50][51][52][53]. In the dedifferentiated (recurrent) acinic cell carcinoma presented by Piana et al [42], there was evidence of myoepithelial differentiation (clear cell morphology, widespread positivity for S100 protein and focal immunoreactivity for SMA).…”

Section: Discussionmentioning

confidence: 99%

Anaplastic Myoepithelial Carcinoma of the Sinonasal Tract: an Underrecognized Salivary-Type Tumor Among the Sinonasal Small Round Blue Cell Malignancies? Report of One Case and a Review of the Literature

Petersson

Chao

2010

Head and Neck Pathol

View full text Add to dashboard Cite

We present a 45 year old female patient with a nasal carcinoma showing high-grade/anaplastic histomorphological features and with a distinct myoepithelial immunohistochemical phenotype including positivity for smooth muscle actin, p63, S100 protein with no sustentacular pattern, calponin, cytokeratin 14, vimentin and cytokeratins (AE1-3 and CK5/6). A minority (\5%) of the cells showed focal and variable immunoreactivity for EMA with no cuticular/canalicular pattern. Bcl-2, CD99, CD117 and CD56 were variously positive, but chromogranin and synaptophysin were negative. Weak to moderate nuclear p53 immunoreactivity was seen in 50% of tumor cells. Mib-1/Ki-67 showed an average proliferation of 60-70%. Fluorescent in situ hybridization revealed no EWS-gene translocation. In situ hybridization for EBER was negative.

show abstract

“…Malignant salivary gland tumors are divided into three groups: low, intermediate, and high grade (1). An epithelial-myoepithelial carcinoma is a low-grade biphasic malignant tumor (2,3). Occasionally, a high-grade or dedifferentiated form may be observed (2,3).…”

Section: Introductionmentioning

confidence: 99%

“…An epithelial-myoepithelial carcinoma is a low-grade biphasic malignant tumor (2,3). Occasionally, a high-grade or dedifferentiated form may be observed (2,3). This malignant tumor can occur in conjunction with hybrid salivary gland tumors, for example, in combination with adenoid cystic carcinomas and lymphoepithelial carcinomas (4,5).…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Clear Cell Carcinoma of the Parotid Gland in Iran

Saberi

Modabbernia

2016

Iran Red Crescent Med J

View full text Add to dashboard Cite

Introduction: Salivary gland tumors are rare head and neck lesions. The majority are benign, with only 20% of cases malignant. An epithelial-myoepithelial carcinoma is a rare low-grade malignant salivary and lacrimal gland tumor, which accounts for less than 1% of salivary gland tumors. It mostly involves the parotid gland and affects adults in their sixth and seventh decades. It is usually painless, unless the minor salivary glands are affected. Case Presentation: We describe a rare case of a 35-year-old woman who presented with a 1-year-old unilateral painful parotid swelling in December 2014. Conclusions: A complete immunohistochemical study should be considered in cases of malignant salivary gland tumors. To reduce the recurrence rate of these tumors, the optimum therapies are radiotherapy and chemotherapy.

show abstract

Dedifferentiated epithelial-myoepithelial carcinoma of the parotid gland: a rare case report of immunohistochemical analysis and review of the literature

Cited by 56 publications

References 26 publications

Dedifferentiated fat cells: an alternative source of adult multipotent cells from the adipose tissues

Dedifferentiated fat cells: an alternative source of adult multipotent cells from the adipose tissues

Anaplastic Myoepithelial Carcinoma of the Sinonasal Tract: an Underrecognized Salivary-Type Tumor Among the Sinonasal Small Round Blue Cell Malignancies? Report of One Case and a Review of the Literature

A Rare Case of Clear Cell Carcinoma of the Parotid Gland in Iran

Contact Info

Product

Resources

About