Dedication to Professor Leslie Z. Benet: 50 Years of Scientific Excellence and Still Going Strong!

The Role of BCS (Biopharmaceutics Classification System) and BDDCS (Biopharmaceutics Drug Disposition Classification System) in Drug Development

“…BDDCS was developed with the purpose of predicting drug disposition and drug–drug interactions, both for drugs on the market and NMEs. Very recently, Professor Amidon has characterized the 2005 BDDCS paper3 as advancing and conceptualizing “a new era of molecular ADME.”40 He has very graciously written, “I believe this 2005 BDDCS paper is a seminal concept in development in the field of molecular ADME of drugs and will have a profound impact on drug discovery and development in the 21st century, and eventually human health and quality of life.”40 I certainly hope that he is correct and in this commentary have attempted to lay out the significant role that BCS has played in drug development and the potential for the role that BDDCS may play.…”

Perspectives on a pharmacokinetics legend: C versus T (contributions over time)

“…Many have already elaborated on Dr. Benet's scientific excellence, achievements and contributions over the past 50 some years 1. I hope to add a personal touch to honor Les who is a legend in our field, from my view.…”

“…This theme issue is dedicated to Professor Benet in tribute to his significant contributions to the pharmaceutical sciences. An outstanding commentary that details Professor Benet's career path and scientific achievements over the past 50 years was published recently in Pharm Res 1. We chose to provide a different perspective for the reader by focusing this commentary on those intangible factors that make Professor Benet truly a legend in the pharmaceutical sciences.…”

“…In more recent years, his published papers on the “operational multiple dosing half‐life” to explain drug accumulation in patients, and the influence of dosage form and dosing interval, are yet another example of his efforts to rationally apply pharmacokinetic principles to optimize pharmacotherapy 24. His many significant scientific contributions are described more comprehensively by Smith et al1 in their commentary.…”

Gordon L. Amidon: Very Sustained Drug Absorption

“…By the late 1970s, Gordon was motivated to look at oral absorption much more mechanistically and turned his career interest in the direction of mechanistic mass transport analysis . This became a common theme for much of his later research work . Through the 1980s, he studied nutrient digestion and absorption, particularly for amino acids and peptides .…”