Decursin Alleviates Mechanical Allodynia in a Paclitaxel-Induced Neuropathic Pain Mouse Model

Son, Dang Bao; Choi, Woosik; Kim, Mingu; Go, Eun Jin; Jeong, Dabeen; Kim, Yong Ho; Lee, Hanki; Suh, Joo‐Won

doi:10.3390/cells10030547

Cited by 16 publications

(14 citation statements)

References 30 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The findings were determined to be in line with those of previous research. Numerous studies have concentrated their attention on the neuronal level of the sciatic nerve and spinal cord in paclitaxel-induced neuropathy and have found morphological abnormalities at both levels [ 49 ]. In addition, we investigated the morphology of two different tissues and came to the conclusion that PTX played a role in the progression of the disease by mediating neuronal degeneration, disrupting the development of myelin sheaths, and causing vacuolation.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effect of Natural Compounds in Paclitaxel-Induced Chronic Inflammatory Pain

Faheem

Khan

Saleem³

et al. 2022

Molecules

View full text Add to dashboard Cite

The current study explored the effects of natural compounds, berbamine, bergapten, and carveol on paclitaxel-associated neuroinflammatory pain. Berbamine, an alkaloid obtained from BerberisamurensisRuprhas been previously researched for anticancer and anti-inflammatory potential. Bergapten is 5-methoxsalenpsoralen previously investigated in cancer, vitiligo, and psoriasis. Carveol obtained from caraway is a component of essential oil. The neuropathic pain model was induced by administering 2 mg/kg of paclitaxel (PTX) every other day for a week. After the final PTX injection, a behavioral analysis was conducted, and subsequently, tissue was collected for molecular analysis. Berbamine, bergapten, and carveol treatment attenuated thermal hypersensitivity, improved latency of falling, normalized the changes in body weight, and increased the threshold for pain sensation. The drugs increased the protective glutathione (GSH) and glutathione S-transferase (GST) levels in the sciatic nerve and spinal cord while lowering inducible nitric oxide synthase (iNOS) and lipid peroxidase (LPO). Hematoxylin and eosin (H and E) and immunohistochemistry (IHC) examinations confirmed that the medication reversed the abnormal alterations. The aforementioned natural substances inhibited cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-α), and nuclear factor kappa B (NF-κb) overexpression, as evidenced by enzyme-linked immunosorbant assay (ELISA) and Western blot and hence provide neuroprotection in chronic constriction damage.

show abstract

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effect of Natural Compounds in Paclitaxel-Induced Chronic Inflammatory Pain

Faheem

Khan

Saleem³

et al. 2022

Molecules

View full text Add to dashboard Cite

show abstract

“…10. One of the important aspects of paclitaxelinduced neuropathy is the disturbance in latency of falling [40], body weight [41], and mechanical allodynia [42]. The behavioral analysis of our compounds reveals that berbamine, bergepten and carveol are corrected the behavioral de cit in paclitaxel-induced peripheral neuropathic pain as is shown in Fig.…”

Section: Discussionmentioning

confidence: 56%

Neuroprotective Effects of Berbamine, Bergepten, and Carveol on Paclitaxel-Induced Peripheral Neuropathy

Faheem

Khan

Ijaz³

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: The current study investigates the effects of natural chemicals like berbamine (BBR), bergepten (BRG), and carveol (CAR) on paclitaxel (PTX) associated neuro-inflammatory pain. Methods: The induction was carried out by administering 2 mg/kg PTX for a week with a day gap. On 7th, 14th and 21st days, behavioral testing was executed, and tissue was removed for molecular analysis. Results: Treatment attenuates thermal hyperalgesia, improved latency of falling, normalized the changes in body weight and increased threshold for pain sensation. The drugs increased the protective GSH and GST levels in the sciatic nerve and spinal cord, while lowering iNOS and LPO. H and E and IHC examinations confirmed that the medication reversed the abnormal alterations. Conclusion: The aforementioned natural substances inhibit COX-2, TNF-α and NF-κB over-expression, as evidenced by enzyme-linked immunosorbent assay (Elisa) and western blot, and hence provide neuroprotection in chronic constriction damage.

show abstract

“…Accumulating evidence suggests that phytochemicals can affect the central nervous system by crossing the BBB. Thus, these phytochemicals may have played a role in the analgesic effect of JI017 as decursin has been reported to attenuate paclitaxel-induced pain and to act as an TRPV1 antagonist [65], while aconitine has also been shown to have an analgesic effect on various animal models of pain [66]. The analgesic effect of 6-gingerol was also reported in several studies [67][68][69].…”

Section: Discussionmentioning

confidence: 87%

JI017 Attenuates Oxaliplatin-Induced Cold Allodynia via Spinal TRPV1 and Astrocytes Inhibition in Mice

Lee

et al. 2021

IJMS

View full text Add to dashboard Cite

Oxaliplatin, a well-known chemotherapeutic agent, can induce severe neuropathic pain, which can seriously decrease the quality of life of patients. JI017 is an herb mixture composed of Aconitum carmichaelii, Angelica gigas, and Zingiber officinale. Its anti-tumor effect has been reported; however, the efficacy of JI017 against oxaliplatin-induced allodynia has never been explored. Single oxaliplatin injection [6 mg/kg, intraperitoneal, (i.p.)] induced both cold and mechanical allodynia, and oral administration of JI017 (500 mg/kg) alleviated cold but not mechanical allodynia in mice. Real-time polymerase chain reaction (PCR) analysis demonstrated that the upregulation of mRNA of spinal transient receptor potential vanilloid 1 (TRPV1) and astrocytes following oxaliplatin injection was downregulated after JI017 treatment. Moreover, TRPV1 expression and the activation of astrocytes were intensely increased in the superficial area of the spinal dorsal horn after oxaliplatin treatment, whereas JI017 suppressed both. The administration of TRPV1 antagonist [capsazepine, intrathecal (i.t.), 10 μg] attenuated the activation of astrocytes in the dorsal horn, demonstrating that the functions of spinal TRPV1 and astrocytes are closely related in oxaliplatin-induced neuropathic pain. Altogether, these results suggest that JI017 may be a potent candidate for the management of oxaliplatin-induced neuropathy as it decreases pain, spinal TRPV1, and astrocyte activation.

show abstract

Decursin Alleviates Mechanical Allodynia in a Paclitaxel-Induced Neuropathic Pain Mouse Model

Cited by 16 publications

References 30 publications

Neuroprotective Effect of Natural Compounds in Paclitaxel-Induced Chronic Inflammatory Pain

Neuroprotective Effect of Natural Compounds in Paclitaxel-Induced Chronic Inflammatory Pain

Neuroprotective Effects of Berbamine, Bergepten, and Carveol on Paclitaxel-Induced Peripheral Neuropathy

JI017 Attenuates Oxaliplatin-Induced Cold Allodynia via Spinal TRPV1 and Astrocytes Inhibition in Mice

Contact Info

Product

Resources

About