Neuroprotective Effects of Berbamine, Bergepten, and Carveol on Paclitaxel-Induced Peripheral Neuropathy

Abstract

Background: The current study investigates the effects of natural chemicals like berbamine (BBR), bergepten (BRG), and carveol (CAR) on paclitaxel (PTX) associated neuro-inflammatory pain. Methods: The induction was carried out by administering 2 mg/kg PTX for a week with a day gap. On 7th, 14th and 21st days, behavioral testing was executed, and tissue was removed for molecular analysis. Results: Treatment attenuates thermal hyperalgesia, improved latency of falling, normalized the changes in body weight and increased threshold for pain sensation. The drugs increased the protective GSH and GST levels in the sciatic nerve and spinal cord, while lowering iNOS and LPO. H and E and IHC examinations confirmed that the medication reversed the abnormal alterations. Conclusion: The aforementioned natural substances inhibit COX-2, TNF-α and NF-κB over-expression, as evidenced by enzyme-linked immunosorbent assay (Elisa) and western blot, and hence provide neuroprotection in chronic constriction damage.