Decreasing myocardial estrogen receptors and antioxidant activity may be responsible for increasing ischemia- and reperfusion-induced ventricular arrhythmia in older female rats

Bozdoğan, Ömer; Bozcaarmutlu, Azra; Kaya, Salih Tunç; Sapmaz, Canan; Özarslan, Talat Oğulcan; Ekşioğlu, Didem; Yaşar, Selçuk

doi:10.1016/j.lfs.2021.119190

Cited by 7 publications

(4 citation statements)

References 53 publications

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“…The underlying cause may be related to the instability of action potential resulting from the inability of mitochondria to recover or maintain their inner membrane potential after prolonged ischemia ( 39 – 41 ). Moreover, this phenomenon is more common and severe in elderly female rats ( 42 ), which may be associated with the decline of estrogen receptors and antioxidant activity in their myocardium, rather than the decrease in serum estrogen levels ( 43 ).…”

Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of myocardial ischemia/reperfusion injury from 2000 to 2023

Wang

Guo

Zhang

et al. 2023

Front. Cardiovasc. Med.

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BackgroundMyocardial ischemia/reperfusion injury (MIRI) refers to the more severe damage that occurs in the previously ischemic myocardium after a short-term interruption of myocardial blood supply followed by restoration of blood flow within a certain period of time. MIRI has become a major challenge affecting the therapeutic efficacy of cardiovascular surgery.MethodsA scientific literature search on MIRI-related papers published from 2000 to 2023 in the Web of Science Core Collection database was conducted. VOSviewer was used for bibliometric analysis to understand the scientific development and research hotspots in this field.ResultsA total of 5,595 papers from 81 countries/regions, 3,840 research institutions, and 26,202 authors were included. China published the most papers, but the United States had the most significant influence. Harvard University was the leading research institution, and influential authors included Lefer David J., Hausenloy Derek J., Yellon Derek M., and others. All keywords can be divided into four different directions: risk factors, poor prognosis, mechanisms and cardioprotection.ConclusionResearch on MIRI is flourishing. It is necessary to conduct an in-depth investigation of the interaction between different mechanisms and multi-target therapy will be the focus and hotspot of MIRI research in the future.

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Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of myocardial ischemia/reperfusion injury from 2000 to 2023

Wang

Guo

Zhang

et al. 2023

Front. Cardiovasc. Med.

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“…Regarding cardiac parameters, the relative weight of myocardium and of the left ventricle decreased significantly after ovariectomy and were completely reversed by estradiol substitution to values similar as in the sham group. These findings could be explained by rapid decrease of myocardial mass due also at least partly to rapid decrease of sex hormones and decreased number of estradiol receptors in cardiac tissue after ovariectomy and their restoration after estradiol substitution [ 27 , 28 ]. Changes levels of estradiol could be also the cause of the significant changes of the heart rate, this could be caused also by changes in estradiol receptors function and their impact on sensitivity of the heart to stress.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular, Metabolic and Inflammatory Changes after Ovariectomy and Estradiol Substitution in Hereditary Hypertriglyceridemic Rats

Piťha

Hüttl

Malínská

et al. 2022

IJMS

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Background: If menopause is really independent risk factor for cardiovascular disease is still under debate. We studied if ovariectomy in the model of insulin resistance causes cardiovascular changes, to what extent are these changes reversible by estradiol substitution and if they are accompanied by changes in other organs and tissues. Methods: Hereditary hypertriglyceridemic female rats were divided into three groups: ovariectomized at 8th week (n = 6), ovariectomized with 17-β estradiol substitution (n = 6), and the sham group (n = 5). The strain of abdominal aorta measured by ultrasound, expression of vascular genes, weight and content of myocardium and also non-cardiac parameters were analyzed. Results: After ovariectomy, the strain of abdominal aorta, expression of nitric oxide synthase in abdominal aorta, relative weight of myocardium and of the left ventricle and circulating interleukin-6 decreased; these changes were reversed by estradiol substitution. Interestingly, the content of triglycerides in myocardium did not change after ovariectomy, but significantly increased after estradiol substitution while adiposity index did not change after ovariectomy, but significantly decreased after estradiol substitution. Conclusion: Vascular and cardiac parameters under study differed in their response to ovariectomy and estradiol substitution. This indicates different effects of ovariectomy and estradiol on different cardiovascular but also extracardiac structures.

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“…If we consider that the average HR value with the range reported in telemetry studies involving male rats is our desired reference value, then a slightly increased average HR in pentobarbital (approximately 28 beats/min.) [32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51], and urethane anesthesia (approximately 32 beats/min) [52][53][54][55][56][57][58][59][60]. In female rats under pentobarbital anesthesia, baseline HR values were reported in only one study, depending on the LD Table 1.…”

Section: General Anesthesia and Hrmentioning

confidence: 99%

Rat Electrocardiography and General Anesthesia

Švorc¹

2023

Novel Pathogenesis and Treatments for Cardiovascular Disease

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General anesthesia is an established and well-known factor with a significant impact on cardiac parameters, which can be a problem in the final evaluation of changes in the individual electrophysiological myocardial parameters after various interventions. The present chapter provides a composite review of published data on electrocardiographic parameters (heart rate, PR interval, P wave duration, P wave amplitude, QRS complex, QT and QTc interval duration, and R wave and T wave amplitude) for in vivo rat experiments under general anesthesia from 130 articles, which were retrieved from a search of the Web of Science database, for articles published mainly between 2000 and 2021. ECG parameters reported as baseline or control values were summarized, and averages with ranges were calculated. It is important to be cautious in interpreting the results of such studies and discussions addressing the mechanisms underlying a given type of arrhythmia, it is important to acknowledge that initial ECG parameters may already be affected to some extent by general anesthesia as well as by sex and the time of day the experiments are performed. Although it is not an original research work, researchers working with rats in the laboratory, who routinely perform anesthesia, can use this as a reference to look into while analyzing their data.

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Decreasing myocardial estrogen receptors and antioxidant activity may be responsible for increasing ischemia- and reperfusion-induced ventricular arrhythmia in older female rats

Cited by 7 publications

References 53 publications

A bibliometric analysis of myocardial ischemia/reperfusion injury from 2000 to 2023

A bibliometric analysis of myocardial ischemia/reperfusion injury from 2000 to 2023

Cardiovascular, Metabolic and Inflammatory Changes after Ovariectomy and Estradiol Substitution in Hereditary Hypertriglyceridemic Rats

Rat Electrocardiography and General Anesthesia

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