Decreasing incidence of coeliac disease.

Stevens, Fiona; Egan-Mitchell, B; Cryan, Eilis M.; McCarthy, Colm; McNicholl, B

doi:10.1136/adc.62.5.465

Cited by 79 publications

(46 citation statements)

References 12 publications

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“…The answer to this question, however, lies beyond the scope of this study. 7 after the antithymocyte serum was also reduced if the rats had been given decorin for four or six days. Urine protein to creatinine ratios were 0-7 in normal rats, 15-2 in glomerulonephritic rats given no decorin, 14'8 in those given decorin for two days, and 2 4 in those given it for four or six days (p=0-01 for four or six days decorin compared with no decorin).…”

Section: Clinical Studymentioning

confidence: 98%

Different features of coeliac disease in two neighbouring countries.

Ascher

Holm

Kristiansson

et al. 1993

Archives of Disease in Childhood

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Section: Clinical Studymentioning

confidence: 98%

Different features of coeliac disease in two neighbouring countries.

Ascher

Holm

Kristiansson

et al. 1993

Archives of Disease in Childhood

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“…For the calculation of the predictive values, hypothetical incidences of 1:500, 1:1000 and 1:2000 were used based on literature data from other countries (14)(15)(16)(17).…”

Section: Discussionmentioning

confidence: 99%

Serum antigliadin antibody levels as a screening criterion before jejunal biopsy indication for celiac disease in a developing country

Bahia

Rabello²,

Filho

et al. 2001

Braz J Med Biol Res

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The objective of the present study was to determine the efficacy of detection of antigliadin immunoglobulins G and A (IgG and IgA) for the diagnosis of celiac disease in a developing country, since other enteropathies might alter the levels of these antibodies. Three groups were studied: 22 patients with celiac disease (mean age: 30.6 months), 61 patients with other enteropathies (mean age: 43.3 months), and 46 patients without enteropathies (mean age: 96.9 months). Antigliadin IgG and IgA ELISA showed sensitivity of 90.9 and 95.5%, respectively. With the hypothetical values of prevalence ranging from 1:500 to 1:2000 liveborns, the positive predictive value varied from 8.5 to 2.3% for IgG and from 4.8 to 1.1% for IgA. Considering the patients without enteropathies, specificity was 97.8 and 95.7% for IgG and IgA, respectively. In patients with other enteropathies, specificity was 82.0 and 84.1%, respectively. When patients with and without other enteropathies were considered as a whole, specificity was 88.8 and 91.6%, respectively. The specificity of positive IgG or IgA was 93.5% in children without enteropathies and 78.7% in the presence of other enteropathies. The negative predictive value for hypothetical prevalences varying from 1:500 to 1:2000 liveborns was 99.9%. Thus, even in developing countries where the prevalence of non-celiac enteropathies is high, the determination of serum antigliadin antibody levels is a useful screening test prior to the jejunal biopsy in the investigation of intestinal malabsorption.

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“…It is known for a long time that breast feeding has a protective effect against the development of celiac disease, especially when it is still ongoing during gluten introduction in the diet. Also the improvement of infant milk formula, decreasing protein content and osmolarity, has helped to reduce celiac disease incidence [18]. Obviously, the easiest way to reduce the amount of gluten ingestion is the reduction of wheat-derived products consumption, but this would mean a kind of "preventive gluten-free diet", with all the problems and limitations previously described (first of all the decrease in life quality).…”

Section: Introductionmentioning

confidence: 99%

Celiac Disease: Gluten Peptides Characterization after In Vitro Digestion

Prandi¹

2017

Wheat Improvement, Management and Utilization

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Gluten proteins are characterized by the high glutamine and proline content; thus, during gluten digestion, several resistant peptides are produced. Some of them contain sequences that, in celiac patients, are able to trigger an immunological reaction. The prolamin fraction of different wheat samples was submitted to in vitro digestion, and the peptides generated were analysed using liquid chromatography coupled to mass spectrometry techniques. Several wheat varieties were analysed, showing large differences in the production of immunotoxic peptides on digestion. After simulated gastrointestinal digestion of wheat, emerged that peptides containing sequences known to elicit the adaptive immune response derived mainly from γ-gliadin, whereas peptides containing sequences involved in the innate immune response were distributed among α-gliadin and γ-gliadin and low-molecular-weight glutenins. From the results, no major differences due to the different cultivation places were observed. On the other hand, statistically significant differences are present among the genotypes tested, especially for the immunogenic peptides. The possible development would be the selection of wheat genotypes with reduced amount of immunogenic sequences, to reduce the exposure of people and decrease the risk of new cases of disease.

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Decreasing incidence of coeliac disease.

Cited by 79 publications

References 12 publications

Different features of coeliac disease in two neighbouring countries.

Different features of coeliac disease in two neighbouring countries.

Serum antigliadin antibody levels as a screening criterion before jejunal biopsy indication for celiac disease in a developing country

Celiac Disease: Gluten Peptides Characterization after In Vitro Digestion

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