Decreased umbilical orexin‐A level is associated with idiopathic polyhydramnios

Cho, Geum Joon; Hong, Hye Jin; Kim, Suhng Wook; Hong, Soon Cheol; Oh, Min Jeong; Kim, Hai Joon

doi:10.1111/aogs.12559

Cited by 5 publications

(2 citation statements)

References 40 publications

(52 reference statements)

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“…Maternal serum orexin‐A level is higher than the umbilical cord orexin‐A level. Inconsistent with our results, Cho et al, 34 and Yilmaz et al 35 showed a positive and significant correlation between maternal and umbilical cord serum orexin‐A levels. Orexin‐A is produced during pregnancy from the hypothalamus (blood–brain barrier transport) 7 and placenta 2 .…”

Section: Discussionsupporting

confidence: 83%

“…Consistent findings are found in Aran et al 38 study who observed that orexin‐A level in CSF does not significantly correlate with the infant birth weight. In contrast, Cho et al 34 reported that maternal/cord serum orexin‐A levels have a negative association with birth weight. Moreover, Kahraman et al 39 showed that serum orexin‐A level found in malnourished children was not related to their height, although there was a negative relationship between serum orexin‐A levels with BMI and children's weight.…”

Section: Discussionmentioning

confidence: 89%

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The influence of mode of delivery, anthropometric indices, and infant's sex on the maternal and cord blood orexin‐A levels: A cohort study

Razavinia

Tehranian

Sadatmahalleh

et al. 2021

J of Obstet and Gynaecol

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Background Orexin as an adipokin hormone plays an important role in appetite regulation, energy metabolism, obesity, diabetes, and cardiovascular disease. The main source of orexin secretion in nonpregnant and pregnant women is adipose tissue and placenta, respectively. This research was conducted to evaluate the association between orexin‐A level and the mode of delivery, anthropometric indices, and sex of the infant. Methods This prospective cohort study was conducted on 69 normal pregnant women. The samples of umbilical cord blood were obtained at the time of delivery, and maternal blood was taken within 24 h of delivery. Serum orexin‐A levels were measured by using enzyme‐linked immunosorbent assay. Statistical analyses were performed using SPSS and p < 0.05 was considered as significant. Results We found a significant difference between postpartum maternal and umbilical cord orexin‐A level both with the mode of delivery (p < 0.001). Also, a significant positive correlation was seen between maternal and umbilical cord serum orexin‐A levels (r = −0.61, p < 0.001). There was no relationship between serum orexin‐A levels with anthropometric indices and the sex of the neonate (p > 0.05). Conclusion Both maternal and umbilical cord serum orexin‐A levels were associated with the mode of delivery. Maternal and cord blood orexin‐A levels in normal vaginal delivery are higher than cesarean section.

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