1999
DOI: 10.1016/s0741-5214(99)70135-7
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Abstract: A decreased CO(2) reactivity appears to be associated with a disordered cerebral metabolism. Patients with severe bilateral ICA stenosis are at risk for disordered cerebral metabolism and hemodynamics. Therefore, the indication for CEA based on the degree of ICA stenosis and clinical grounds might be refined with an additional test, such as the TCD CO(2) reactivity test.

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Cited by 17 publications
(5 citation statements)
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References 32 publications
(39 reference statements)
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“…TCD‐based techniques are cheap and simple and are tolerated by almost all patients. Impaired reactivity determined using this method correlated with evidence of ischaemia on magnetic resonance spectroscopy, as determined by the presence of lactate and a reduction in the neuronal marker N ‐acetyl aspartate 15 . It also correlated with vasodilatation, detected as an increased cerebral blood volume (CBV) to cerebral blood flow (CBF) ratio, estimated by positron emission tomography (PET) 16 .…”
Section: Discussionmentioning
confidence: 90%
See 1 more Smart Citation
“…TCD‐based techniques are cheap and simple and are tolerated by almost all patients. Impaired reactivity determined using this method correlated with evidence of ischaemia on magnetic resonance spectroscopy, as determined by the presence of lactate and a reduction in the neuronal marker N ‐acetyl aspartate 15 . It also correlated with vasodilatation, detected as an increased cerebral blood volume (CBV) to cerebral blood flow (CBF) ratio, estimated by positron emission tomography (PET) 16 .…”
Section: Discussionmentioning
confidence: 90%
“…Impaired reactivity determined using this method correlated with evidence of ischaemia on magnetic resonance spectroscopy, as determined by the presence of lactate and a reduction in the neuronal marker N-acetyl aspartate. 15 It also correlated with vasodilatation, detected as an increased cerebral blood volume (CBV) to cerebral blood flow (CBF) ratio, estimated by positron emission tomography (PET). 16 Other options include stable xenon-CT (also used in our unit), single photon emission computed tomography (SPECT), PET, and magnetic resonance imaging (MRI) to have quantitative or relative measurement of CBF and CBV.…”
Section: -11mentioning
confidence: 98%
“…Visser et al 28 found a positive correlation between the ratio of NAA to choline and cerebral vasoreactivity in patients with severe ICA stenosis. However, they included asymptomatic patients, which may have influenced the observed correlation.…”
Section: Discussionmentioning
confidence: 98%
“…This technical defect may lead to blood flow disturbances and thromboembolism. 9,10 Some authors have argued that it is critical understanding of the pathophysiology of post-operative stroke in carotid artery surgery. Some of these stroke cases can be avoided and are associated with the shunt.…”
Section: Hemodynamic and Cerebral Measurementsmentioning
confidence: 99%