Decreased theophylline half-life in cigarette smokers

Jenne, John W.; Nagasawa, Hiromichi; McHugh, Richard; MacDonald, Frank M.; Wyse, Eduardo P.

doi:10.1016/0024-3205(75)90503-2

Cited by 128 publications

(24 citation statements)

References 10 publications

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“…Several reports exist on the influence of cigarette smoke on drug pharmacokinetics [2,[5][6][7], Smoking may, for example, en hance the hepatic metabolism of theophyl line. lidocaine.…”

Section: Discussionmentioning

confidence: 99%

“…11], Cigarette, tobacco or cigar smoking may also be pointed out as factors that influence drug action and drug metabolism. Numerous clinical studies have shown that the pharmacokinetics of some drugs are influenced by smoking [6,7], For example, theophylline is eliminated more rapidly in smokers than in nonsmokers, and smoking shortens the half-life of theophyl line. increases its clearance and reduces its blood levels [5][6][7], The frequency of drowsi ness caused by phenothiazines and benzodi azepines is lower when psychotropic drugs arc administered to smokers [2], These data suggest that the pharmacokinetics of those drugs are influenced by nicotine, by compo nents of cigarettes or tobacco other than nicotine or by both.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Standard Cigarette and Nicotine-Less Cigarette Smoke Inhalings on Nicorandil Plasma Levels in Rats

Gomita

Eto²,

Furuno³

et al. 1990

Pharmacology

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The influence of cigarette smoke on nicorandil plasma levels at a dose of 10 mg/kg administered orally was investigated in rats. The animals were exposed to standard and nicotineless cigarette smoke for 8 min using a ‘smoking machine’. In nonsmoking control rats, nicorandil plasma levels increased rapidly and reached the maximum (approx. 7.6 μg/ml) after 1 h and then decreased gradually. On the other hand, nicorandil plasma levels in the rats inhaling standard cigarette and nicotine-less cigarette smoke reached the maximum (approx. 4.7 and 4.9 μg/ml, respectively) after 1–2 h. These results suggest that nicorandil plasma levels after oral administration are influenced not only by standard cigarette smoke but also by nicotine-less cigarette smoke.

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“…Several reports exist on the influence of cigarette smoke on drug pharmacokinetics [2,[5][6][7], Smoking may, for example, en hance the hepatic metabolism of theophyl line. lidocaine.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Standard Cigarette and Nicotine-Less Cigarette Smoke Inhalings on Nicorandil Plasma Levels in Rats

Gomita

Eto²,

Furuno³

et al. 1990

Pharmacology

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“…Theophylline is rapidly absorbed when administered orally in an aqueous-ethanol solution (12), and is metabolized primarily by the liver microsomal system (13). Unlike antipyrine, however, theophylline metabolism has been shown to be increased in vitro by pretreatment of rats with the polycyclic hydrocarbon 3-methylcholanthrene (13), and in man its kinetic disposition is accelerated in chronic smokers (14); however, its disposition is not significantly altered by phenobarbital administration in man (15). These observations indicate that theophylline may be a prototype of a drug metabolized by the cytochrome P-448 system, a catalytically distinct hemeprotein induced primarily by polycyclic hydrocarbons and polychlorinated biphenyls (16).…”

mentioning

confidence: 99%

Interactions between nutritional factors and drug biotransformations in man.

Alvares¹,

Anderson²,

Conney³

et al. 1976

Proc. Natl. Acad. Sci. U.S.A.

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This study was undertaken to examine the influence of nutritional factors on the activity of the mixed function oxidase system in man, which is cytochrome P450 dependent. Three normal volunteers were fed a low carbohydrate-high protein diet for 2 weeks, followed by a high carbohydrate-low protein diet for the following 2 weeks. At the end of each test diet period, the plasma elimination rates of antipyrine and theophylline were determined. The mean plasma half-life for antipyrine was 17.5 hr on the high carbohydrate-low protein diet and 9.2 hr on the low carbohydrate-high protein diet. The mean plasma half-life for theophylline was 8.9 hr on the high carbohydrate-low protein diet and 5.9 iwr on the low carbohydrate-high protein diet. These data demonstrate marked influences of dietary carbohydrate and/or protein ingestion on oxidative biotransformation of drugs in man. The effects of changes in dietary macronutrient composition on the hepatic microsomal enzymes that metabolize drugs, other foreign chemicals, and endogenous compounds, such as steroid hormones, have been studied extensively in animals (1). These studies show that dietary macronutrient composition, as well as the presence of contaminants and food additives, can influence the activities of these enzymes. Although dietary composition has been shown to be an important environmental determinant in the response of the experimental animal to pharmacological agents, such studies are lacking in man. A significant proportion of normal subjects manipulate their diets in weight-reducing regimens. Similarly, dietary treatments in clinical conditions, including obesity, atherosclerosis, and diabetes, are considered to play a significant role in the management of such disease problems. It is the purpose of these studies to show that nutritional-pharmacological interactions can occur in normal individuals when macronutrient composition of the diet is altered.In animals, in relation to hepatic microsomal enzyme activities, the dietary constituent most studied is protein. A reduction in dietary protein intake has been shown to decrease microsomal oxidations of various substrates, such as pentobarbital, aminopyrine, and zoxazolamine (2), and to increase the toxicity of foreign compounds, such as drugs (2) and pesticides (3, 4). The decreases in microsomal oxidations are accompanied by decreases in hepatic content of the hemeprotein cytochrome P-450, the terminal oxidase of the hepatic mixed function oxidase system. In contrast, the metabolism of the drugs indicated is increased in rats fed a high protein diet (2). A high carbohydrate intake has been shown to increase barbiturate-induced sleeping time in mice (5), to cause cessation of lipid peroxidase activity, and to cause a considerable decrease in liver mixed function oxidase activity in rats (6). A specific lipid role in the mixed function oxidase system was first demonstrated by Strobel et al. (7), who established the requirement for phosphatidylcholine in a reconstituted mixed function oxidase system. ...

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“…Published articles have studied pharmacokinetics of this drug [2][3][4]. There are also reports of tobacco smoke affecting pharmacokinetics of various drugs; Elimination rate was increased in theophylline [5][6][7], imipramine [8], propranolol [9] and oxazpam [10] in smoker subjects. No difference was observed in multiple dose pharmacokinetics of phenobarbital in nonsmokers in comparison with the smokers [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Effect of smoking on single dose pharmacokinetics of phenobarbital

Mirfazaelian¹,

Jahanzad²,

Tabatabaei-far³

et al. 2001

Biopharm & Drug Disp

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In order to determine interaction of smoking with single dose pharmacokinetics of phenobarbital, a 60 mg tablet of the drug was given to 12 healthy male subjects in two groups (6 smokers and 6 non-smokers) in a double blind study. An HPLC method using UV detection was developed to assess phenobarbital in plasma of the subjects. Pharmacokinetic parameters were calculated and compared in the two groups. Pharmacokinetic parameters of the two groups were not significantly different in the two groups (p<0.05). The results show no considerable effect of cigarette smoking on phenobarbital pharmacokinetics, which is in agreement with enzyme studies performed previously.

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Decreased theophylline half-life in cigarette smokers

Cited by 128 publications

References 10 publications

Effects of Standard Cigarette and Nicotine-Less Cigarette Smoke Inhalings on Nicorandil Plasma Levels in Rats

Effects of Standard Cigarette and Nicotine-Less Cigarette Smoke Inhalings on Nicorandil Plasma Levels in Rats

Interactions between nutritional factors and drug biotransformations in man.

Effect of smoking on single dose pharmacokinetics of phenobarbital

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