Decreased taurine concentration in skeletal muscles after exercise for various durations

Matsuzaki, Yasushi; Miyazaki, Teruo; Miyakawa, Syumpei; Bouscarel, Bernard; Ikegami, Tadashi; Tanaka, Naomi

doi:10.1097/00005768-200205000-00011

Cited by 53 publications

(52 citation statements)

References 21 publications

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“…The taurine treatment restored MT of exercised dystrophic muscle, in line its high effectiveness when applied in vitro and likely in relation to a direct stimulation of the Ca 2ϩ ATPase pump of sarcoplasmic reticulum (Huxtable, 1992;De Luca et al, 2001). Conditions of muscle taurine depletion are in fact characterized by negative MT and a difficulty of dystrophic muscle to retain adequate amounts of the amino acid has been documented and can be even worsened by exercise (De Luca et al, 1996McIntosh et al, 1998;Matsuzaki et al, 2002). Similarly, PDN was jpet.aspetjournals.org very effective on MT, corresponding to its ability in vitro to decrease cytosolic Ca 2ϩ levels of dystrophic myotubes .…”

Section: Experimental Conditions Drugs In Vitromentioning

confidence: 66%

Enhanced Dystrophic Progression in mdx Mice by Exercise and Beneficial Effects of Taurine and Insulin-Like Growth Factor-1

Pierno²,

Liantonio³

et al. 2003

J Pharmacol Exp Ther

180

283

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A preclinical screening for prompt-to-use drugs that are safer than steroids and beneficial in Duchenne muscular dystrophy was performed. Compounds able to reduce calcium-induced degeneration (taurine or creatine 10% in chow) or to stimulate regeneration [insulin-like growth factor-1 (IGF-1); 50 or 500 g/kg s.c.] were administered for 4 to 8 weeks to mdx mice undergoing chronic exercise on a treadmill, a protocol to worsen dystrophy progression. ␣-Methyl-prednisolone (PDN; 1 mg/kg) was used as positive control. The effects were evaluated in vivo on forelimb strength and in vitro electrophysiologically on the macroscopic chloride conductance (gCl), an index of degeneration-regeneration events in mdx muscles, and on the mechanical threshold, a calcium-sensitive index of excitation-contraction coupling. The exercise produced a significant weakness and an impairment of gCl, by further decreasing the already low value of degenerating diaphragm (DIA) and fully hampering the increase of gCl typical of regenerating extensor digitorum longus (EDL) mdx muscle. The already negative voltage threshold for contraction of mdx EDL was also slightly worsened. Taurine Ͼ creatine Ͼ IGF-1 counteracted the exercise-induced weakness. The amelioration of gCl was drug-and muscle-specific: taurine was effective in EDL, but not in DIA muscle; IGF-1 and PDN were fully restorative in both muscles, whereas creatine was ineffective. An acute effect of IGF-1 on gCl was observed in vitro in untreated, but not in IGF-1-treated exercised mdx muscles. Taurine Ͼ PDN Ͼ IGF-1, but not creatine, significantly ameliorated the negative threshold voltage values of the EDL fibers. The results predict a potential benefit of taurine and IGF-1 for treating human dystrophy.

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Section: Experimental Conditions Drugs In Vitromentioning

confidence: 66%

Enhanced Dystrophic Progression in mdx Mice by Exercise and Beneficial Effects of Taurine and Insulin-Like Growth Factor-1

Pierno²,

Liantonio³

et al. 2003

J Pharmacol Exp Ther

180

283

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“…Matsuzaki et al 31) showed that treadmill exercise to exhaustion decreased taurine levels in the plantaris, gastrocnemius, and extensor digitorum longus muscles in rats; and such exhaustive exercise-induced decreases in muscle taurine levels have been confirmed in other studies 32,33) . On the other hand, we did not find changes in taurine levels in the plantaris or gastrocnemius muscle in rats that had exercised to exhaustion 34) .…”

Section: B) Taurinementioning

confidence: 81%

“…It was shown that prolonged exercise decreased muscle taurine levels in rats [31][32][33] , but the significance of this decrease remains unclear. In humans, muscle taurine levels were unaltered by a 1-h cycle ergometer exercise with a load of approximately 70% V ・ O2max 19) , a cycle ergometer exercise with a load of 75% V ・ O2max for 1 h, a cycle ergometer exercise at maximal work rate for 20 min 20) , and a 2-h cycle ergometer exercise with a load of 60% V ・ O2max 44) .…”

Section: D) Taurinementioning

confidence: 99%

Exercise-induced changes in amino acid levels in skeletal muscle and plasma

Ishikura¹,

Ra²,

Ohmori³

2013

JPFSM

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During exercise, amino acid oxidation and protein breakdown are enhanced while protein synthesis is suppressed, even though protein does not constitute a quantitatively important energy source. In response to exercise-induced stimulation, various changes in free amino acids occur in skeletal muscle to meet physiological demands. Plasma amino acids are also under the influence of various types of stress, including exercise stress. For example, acute exercise increases alanine and glutamine levels, but decreases glutamate levels in skeletal muscle. At the same time, it increases tryptophan and taurine levels, but decreases glutamine levels in plasma. Prolonged exercise decreases glutamine and glutamate levels, while increasing tyrosine and phenylalanine levels in skeletal muscle. Furthermore, when prolonged exercise-induced changes in amino acid levels are compared between trained and untrained individuals, glutamate and taurine levels in skeletal muscle and phenylalanine, leucine, isoleucine, and tyrosine levels in plasma are higher in trained individuals. This review provides an overview of changes in amino acid levels in skeletal muscle and plasma, with a focus on changes induced by exercise.

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“…A reduction in skeletal muscle taurine content following prolonged muscle stimulation has 394 previously been established in vitro Matsuzaki et al 2002). Chronic 395 supplementation has been shown to significantly increase muscle taurine concentration resulting in 396 increased muscle force production and partially counteracting the effect of intramuscular taurine 397 depletion that occurs during fatigue (Goodman et concentration (Askew, 1997).…”

Section: The Effect Of Physiological Concentrations Of Taurine and Camentioning

confidence: 99%

“…Reducing the intracellular concentration of taurine has commonly been shown 67 to result in a reduction in skeletal muscle function, primarily resulting in a decrease in muscle force 68 production (Hamilton et al 2006). Evidence is also presented to suggest that depletion of muscular 69 taurine occurs during prolonged muscle activation ; Matsuzaki et al 2002), therefore 70 suggesting a link between fatigue and muscular taurine concentration. 71…”

Section: Introduction 51mentioning

confidence: 99%

Does a physiological concentration of taurine increase acute muscle power output, time to fatigue, and recovery in isolated mouse soleus (slow) muscle with or without the presence of caffeine?

Tallis

Higgins

Cox

et al. 2014

Can. J. Physiol. Pharmacol.

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when combined with a high concentration of taurine. However, the high concentration of caffeine 34 used in previous research would be toxic for human consumption. Therefore the present study aims 35 to investigate the direct effect of a physiological dose of caffeine and taurine to potentiate skeletal 36 muscle performance. Isolated mouse soleus muscle was used to examine the effects of physiological 37 taurine (TAU), caffeine (CAF), and taurine-caffeine combined (TC) on: 1) acute muscle power output; 382) time to fatigue; and 3) fatigue recovery, compared to untreated controls (CON). Treatment with 39 TAU failed to elicit any significant difference in the measured parameters. Treatment with TC 40 resulted in a significant increase in acute muscle power output and faster time to fatigue. The 41 ergogenic benefit posed by TC was not different from the effects of caffeine alone, suggesting no 42 acute ergogenic benefit of taurine. 43

show abstract

Decreased taurine concentration in skeletal muscles after exercise for various durations

Abstract: Taurine concentration was decreased in all skeletal muscles after exercise, regardless of the duration. Moreover, this decrease was specific to fast-twitch dominant fibers. However, under these conditions, the plasma taurine concentration remained unchanged.

Cited by 53 publications

References 21 publications

Enhanced Dystrophic Progression in mdx Mice by Exercise and Beneficial Effects of Taurine and Insulin-Like Growth Factor-1

Enhanced Dystrophic Progression in mdx Mice by Exercise and Beneficial Effects of Taurine and Insulin-Like Growth Factor-1

Exercise-induced changes in amino acid levels in skeletal muscle and plasma

Does a physiological concentration of taurine increase acute muscle power output, time to fatigue, and recovery in isolated mouse soleus (slow) muscle with or without the presence of caffeine?

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