Decreased submandibular adiponectin is involved in the progression of autoimmune sialoadenitis in non‐obese diabetic mice

Yc, Su; Rl, Xiang; Zhang, Y; Ding, Chong; Cong, Xin; Xh, Guo; Ny, Yang; Hu, Hua; Ll, Wu; Yu, Guohui

doi:10.1111/odi.12197

Cited by 14 publications

(14 citation statements)

References 48 publications

(68 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The impairment of epithelial cells directly results in the secretory dysfunction (Fox, ; Mitsias, Kapsogeorgou, & Moutsopoulos, ). Here, we found that apoptosis was increased in the submandibular glands of NOD mice, which is consistent with our previous study (Su et al, ). SHED treatment decreased apoptosis.…”

Section: Discussionsupporting

confidence: 93%

“…week-old mice. The SS-like phenotype in NOD mice was consistent with our previous study (Su et al, 2014).…”

Section: Discussionsupporting

confidence: 92%

“…Inflammatory lesions appeared in 7‐week‐old mice and were significantly present in 14‐ and 21‐week‐old mice. The SS‐like phenotype in NOD mice was consistent with our previous study (Su et al, ).…”

Section: Discussionsupporting

confidence: 92%

See 2 more Smart Citations

Stem cells from exfoliated deciduous teeth alleviate hyposalivation caused by Sjögren syndrome

Ding

Zhang

et al. 2019

Oral Diseases

View full text Add to dashboard Cite

Objectives To evaluate the effect of stem cells from exfoliated deciduous teeth on the hyposalivation caused by Sjögren syndrome (SS) and investigate the mechanism. Methods Stem cells were injected into the tail veins of non‐obese diabetic mice, the animal model of SS. The saliva flow was measured after pilocarpine intraperitoneal injection. Apoptosis and autophagy were evaluated by TUNEL and Western blot. Lymphocyte proportions were detected by flow cytometer. Results Fluid secretion was decreased in 21‐week‐old mice. Stem cell treatment increased fluid secretion, alleviated inflammation in the submandibular glands and reduced inflammatory cytokine levels in the serum, submandibular glands and saliva. Stem cells decreased the apoptotic cell number and the expressions of ATG5 and Beclin‐1 in the submandibular glands. Stem cells have no effect on other organs. Furthermore, the infused stem cells migrated to the spleen and liver, not the submandibular gland. Stem cells directed T cells towards Treg cells and suppressed Th1 and Tfh cells in spleen lymphocytes. Conclusion Stem cells from exfoliated deciduous teeth alleviate the hyposalivation caused by SS via decreasing the inflammatory cytokines, regulating the inflammatory microenvironment and decreasing the apoptosis and autophagy. The stem cells regulated in T‐cell differentiation are involved in the immunomodulatory effects.

show abstract

Section: Discussionsupporting

confidence: 93%

“…week-old mice. The SS-like phenotype in NOD mice was consistent with our previous study (Su et al, 2014).…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Stem cells from exfoliated deciduous teeth alleviate hyposalivation caused by Sjögren syndrome

Ding

Zhang

et al. 2019

Oral Diseases

View full text Add to dashboard Cite

show abstract

“…As adiponectin promotes insulin sensitivity, a compensatory increase of expression of adiponectin may occur in the early stage of low insulin sensitivity of NOD mice. With development of autoimmune sialadenitis, the serum adiponectin level has been shown to decrease in NOD mice 38. Our results showed that, in response to ODN 1826 stimulation, placental adiponectin expression was downregulated in the NOD mouse but not in the WT mouse placenta.…”

Section: Discussionmentioning

confidence: 58%

CpG Oligodeoxynucleotides Downregulate Placental Adiponectin and Increase Embryo Loss in Non‐Obese Diabetic Mice

Qin

Tian

Liu

et al. 2016

American J Rep Immunol

View full text Add to dashboard Cite

ProblemCpG oligodeoxynucleotides (ODNs) can induce immunological changes in non‐obese diabetic (NOD) mice and increase embryo loss, but little is known about the mechanism. This study aimed to determine the role of adiponectin in CpG ODN‐induced pregnancy failure.Method of studyOligodeoxynucleotide 1826 was intraperitoneally injected to NOD mice, and ODN 2216, ODN 2006, and ODN 2395 were used to stimulate human trophoblast cell lines to investigate adiponectin expression patterns and its possible effects on trophoblast function.ResultsCpG ODNs downregulated adiponectin via the cJun N‐terminal kinase signaling pathway and led to increased embryo loss (from 6.9 to 33.3%). ODN 2006 impaired human trophoblast cell migration, which was successfully rescued by adiponectin treatment.ConclusionCpG ODNs decreased placental adiponectin expression in NOD mice and impaired human trophoblast function and was associated with increased embryo loss. Adiponectin may therefore play an important protective role in the prevention of bacteria‐induced pregnancy failure.

show abstract

“…Similarly in psoriasis, basal serum adiponectin levels were lower than healthy controls but increased with treatment [70,98,99]. Mice that develop sialoadenitis, a model for human Sjögren's syndrome, exhibit lower levels of glandular adiponectin, but this is likely related to localized production of adiponectin [100]. Clearly there is significant evidence that adiponectin impacts inflammatory autoimmunity, but unraveling the role of adiponectin in this context will require a better understanding of the potentially opposing functions it plays in inflammation, whether that is related to isoform differences or some other process.…”

Section: Adiponectinmentioning

confidence: 89%

Adipokines influence the inflammatory balance in autoimmunity

Hutcheson

2015

Cytokine

View full text Add to dashboard Cite

Decreased submandibular adiponectin is involved in the progression of autoimmune sialoadenitis in non‐obese diabetic mice

Abstract: Adiponectin plays a protective role on submandibular cells. Decreased adiponectin might promote glandular destruction in autoimmune sialoadenitis.

Cited by 14 publications

References 48 publications

Stem cells from exfoliated deciduous teeth alleviate hyposalivation caused by Sjögren syndrome

Stem cells from exfoliated deciduous teeth alleviate hyposalivation caused by Sjögren syndrome

CpG Oligodeoxynucleotides Downregulate Placental Adiponectin and Increase Embryo Loss in Non‐Obese Diabetic Mice

Adipokines influence the inflammatory balance in autoimmunity

Contact Info

Product

Resources

About