Adipokines influence the inflammatory balance in autoimmunity

Hutcheson, Jack

doi:10.1016/j.cyto.2015.04.004

Cited by 64 publications

(46 citation statements)

References 177 publications

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“…Thus, the inflammatory state described here might persist, unabated, for decades. Adipokines have been proposed as mediators and perpetuators of chronic inflammatory diseases (37). In this study, two adipokines were identified as being important: leptin and resistin.…”

Section: Discussionmentioning

confidence: 91%

Cytokine signature associated with disease severity in chronic fatigue syndrome patients

Montoya

Holmes

Anderson

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

308

265

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Although some signs of inflammation have been reported previously in patients with myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), the data are limited and contradictory. High-throughput methods now allow us to interrogate the human immune system for multiple markers of inflammation at a scale that was not previously possible. To determine whether a signature of serum cytokines could be associated with ME/CFS and correlated with disease severity and fatigue duration, cytokines of 192 ME/CFS patients and 392 healthy controls were measured using a 51-multiplex array on a Luminex system. Each cytokine’s preprocessed data were regressed on ME/CFS severity plus covariates for age, sex, race, and an assay property of newly discovered importance: nonspecific binding. On average, TGF-β was elevated (P = 0.0052) and resistin was lower (P = 0.0052) in patients compared with controls. Seventeen cytokines had a statistically significant upward linear trend that correlated with ME/CFS severity: CCL11 (Eotaxin-1), CXCL1 (GROα), CXCL10 (IP-10), IFN-γ, IL-4, IL-5, IL-7, IL-12p70, IL-13, IL-17F, leptin, G-CSF, GM-CSF, LIF, NGF, SCF, and TGF-α. Of the 17 cytokines that correlated with severity, 13 are proinflammatory, likely contributing to many of the symptoms experienced by patients and establishing a strong immune system component of the disease. Only CXCL9 (MIG) inversely correlated with fatigue duration.

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Section: Discussionmentioning

confidence: 91%

Cytokine signature associated with disease severity in chronic fatigue syndrome patients

Montoya

Holmes

Anderson

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

308

265

View full text Add to dashboard Cite

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“…Elevated levels of circulating leptin have been associated with multiple autoimmune diseases, both in humans and in animal models of human autoimmunity [108], as discussed below.…”

Section: Leptin and Autoimmunitymentioning

confidence: 99%

Leptin in inflammation and autoimmunity

2017

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After its discovery as a key controller of metabolic function, leptin has been later extensively implicated in additional function including important modulatory activities on the innate and adaptive immune responses. This review analyzes the known implications of leptin in multiple inflammatory conditions, including autoimmune diseases, and how this knowledge could be instrumental in the design of leptin-based manipulation strategies to help restoration of abnormal immune responses.

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“…From the functional viewpoint adipokines are polyvalent molecules, involved in a large number of physiological and pathological processes in fact modulate the sensitivity of peripheral tissues to insulin, regulate appetite, energy expenditure, and glucose and lipids metabolism, homeostasis, angiogenesis, blood pressure and all the axis of endocrine and reproductive systems 57-59. In addition, many appear to be strongly related to immunity and inflammation 60,61. Within this wide range of signals and protein factors, it is evident how the white adipose tissue plays an active role in controlling the physiological and pathological processes, in particular the metabolism and energy homeostasis 62,63.…”

Section: Introductionmentioning

confidence: 99%

Obesity and cancer: the role of adipose tissue and adipo-cytokines-induced chronic inflammation

et al. 2016

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Adipose tissue in addition to its ability to keep lipids is now recognized as a real organ with both metabolic and endocrine functions. Recent studies demonstrated that in obese animals is established a status of adipocyte hypoxia and in this hypoxic state interaction between adipocytes and stromal vascular cells contribute to tumor development and progression. In several tumors such as breast, colon, liver and prostate, obesity represents a poor predictor of clinical outcomes. Dysfunctional adipose tissue in obesity releases a disturbed profile of adipokines with elevated levels of pro-inflammatory factors and a consequent alteration of key signaling mediators which may be an active local player in establishing the peritumoral environment promoting tumor growth and progression. Therefore, adipose tissue hypoxia might contribute to cancer risk in the obese population. To date the precise mechanisms behind this obesity-cancer link is not yet fully understood. In the light of information provided in this review that aims to identify the key mechanisms underlying the link between obesity and cancer we support that inflammatory state specific of obesity may be important in obesity-cancer link.

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Adipokines influence the inflammatory balance in autoimmunity

Cited by 64 publications

References 177 publications

Cytokine signature associated with disease severity in chronic fatigue syndrome patients

Cytokine signature associated with disease severity in chronic fatigue syndrome patients

Leptin in inflammation and autoimmunity

Obesity and cancer: the role of adipose tissue and adipo-cytokines-induced chronic inflammation

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